Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump

The bile salt export pump (BSEP or ABCB11) mediates the adenosine triphosphate–dependent transport of bile salts across the canalicular membrane of the hepatocyte. Mutations in the corresponding ABCB11 gene cause progressive familial intrahepatic cholestasis type 2. The aim of this study was to inve...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2002-03, Vol.35 (3), p.589-596
Hauptverfasser:	Plass, Jacqueline R.M., Mol, Olaf, Heegsma, Janette, Geuken, Mariska, Faber, Klaas Nico, Jansen, Peter L.M., Müller, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP Binding Cassette Subfamily B Member 11 ATP-Binding Cassette Transporters - genetics Base Sequence Biological and medical sciences Chenodeoxycholic Acid - pharmacology Cloning, Molecular Digestive system DNA-Binding Proteins - physiology Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Molecular Sequence Data Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Promoter Regions, Genetic Receptors, Cytoplasmic and Nuclear Receptors, Retinoic Acid - physiology Response Elements Retinoid X Receptors RNA, Messenger - analysis Transcription Factors - physiology Transcription, Genetic Tumor Cells, Cultured
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