Diagnosis and treatment of isolated neck metastases of adenocarcinomas

Aims: Cervical metastases of adenocarcinoma or undifferentiated large cell carcinoma (ULCC) (non-squamous cell carcinoma) of unknown primary origin are rare and often accompanied by distant metastases at multiple sites in the body. Nevertheless, in the past decades, several patients have presented i...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European journal of surgical oncology 2002-03, Vol.28 (2), p.147-152
Hauptverfasser: Zuur, C.L., van Velthuysen, M.L.F., Schornagel, J.H., Hilgers, F.J.M., Balm, A.J.M.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 152
container_issue 2
container_start_page 147
container_title European journal of surgical oncology
container_volume 28
creator Zuur, C.L.
van Velthuysen, M.L.F.
Schornagel, J.H.
Hilgers, F.J.M.
Balm, A.J.M.
description Aims: Cervical metastases of adenocarcinoma or undifferentiated large cell carcinoma (ULCC) (non-squamous cell carcinoma) of unknown primary origin are rare and often accompanied by distant metastases at multiple sites in the body. Nevertheless, in the past decades, several patients have presented in our clinic with isolated neck metastases of this type of malignancy. The aim of our study is to evaluate the clinical behaviour of these cases and to define the role of surgery and radiotherapy. Methods: Over the past 24 years, we selected 15 out of 270 patients (6%) with isolated cervical lymph node metastases of adenocarcinoma (six) or ULCC (nine) of unknown primary origin. Diagnosis was made either by histology or by fine needle aspiration cytology. Treatment consisted of (selective) neck dissection and/or radiotherapy. Results: The clinical presentation of isolated cervical metastases of adenocarcinoma compared with ULCC is equivalent, with an overall median survival time of 25 months (confidence interval 21–29 months). Combined therapy was correlated with an increased and persistent regional control and was associated with longer duration of survival. Conclusions: Patients with isolated cervical neck node metastases of adenocarcinoma or ULCC of unknown primary origin are rare and the diagnostic process to identify this subgroup requires a systemic work-up. In selected cases treatment should concentrate on (selective) neck dissection combined with radiotherapy to achieve a prolonged survival.
doi_str_mv 10.1053/ejso.2001.1222
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71500715</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0748798301912223</els_id><sourcerecordid>71500715</sourcerecordid><originalsourceid>FETCH-LOGICAL-c436t-83842a27d5cfe8e3006983fa43b8395105bf0d6627ea170e667f7a08c48ad2e93</originalsourceid><addsrcrecordid>eNp1kEFv1TAMgCMEYo_BlSPqhd36cJK2SY9oMECaxIWdI7_ERRltMuI-pP17Ur0n7TTJsg_-bNmfEO8l7CX0-hPdc94rALmXSqkXYid7rVole_NS7MB0tjWj1RfiDfM9AIzajK_FhZTWdtDDTtx8ifg7ZY7cYArNWgjXhdLa5KmJnGdcKTSJ_J9moRW5BvHWw0Apeyw-prwgvxWvJpyZ3p3rpbi7-frr-nt7-_Pbj-vPt63v9LC2VttOoTKh9xNZ0gBDvW7CTh-sHvv60WGCMAzKEEoDNAxmMgjWdxaDolFfiqvT3oeS_x6JV7dE9jTPmCgf2RnZA9RUwf0J9CUzF5rcQ4kLlkcnwW3m3GbObebcZq4OfDhvPh4WCk_4WVUFPp4BZI_zVDD5yE-c7ut3g62cPXFUPfyLVBz7SMlTiIX86kKOz93wH2nHiW4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71500715</pqid></control><display><type>article</type><title>Diagnosis and treatment of isolated neck metastases of adenocarcinomas</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Zuur, C.L. ; van Velthuysen, M.L.F. ; Schornagel, J.H. ; Hilgers, F.J.M. ; Balm, A.J.M.</creator><creatorcontrib>Zuur, C.L. ; van Velthuysen, M.L.F. ; Schornagel, J.H. ; Hilgers, F.J.M. ; Balm, A.J.M.</creatorcontrib><description>Aims: Cervical metastases of adenocarcinoma or undifferentiated large cell carcinoma (ULCC) (non-squamous cell carcinoma) of unknown primary origin are rare and often accompanied by distant metastases at multiple sites in the body. Nevertheless, in the past decades, several patients have presented in our clinic with isolated neck metastases of this type of malignancy. The aim of our study is to evaluate the clinical behaviour of these cases and to define the role of surgery and radiotherapy. Methods: Over the past 24 years, we selected 15 out of 270 patients (6%) with isolated cervical lymph node metastases of adenocarcinoma (six) or ULCC (nine) of unknown primary origin. Diagnosis was made either by histology or by fine needle aspiration cytology. Treatment consisted of (selective) neck dissection and/or radiotherapy. Results: The clinical presentation of isolated cervical metastases of adenocarcinoma compared with ULCC is equivalent, with an overall median survival time of 25 months (confidence interval 21–29 months). Combined therapy was correlated with an increased and persistent regional control and was associated with longer duration of survival. Conclusions: Patients with isolated cervical neck node metastases of adenocarcinoma or ULCC of unknown primary origin are rare and the diagnostic process to identify this subgroup requires a systemic work-up. In selected cases treatment should concentrate on (selective) neck dissection combined with radiotherapy to achieve a prolonged survival.</description><identifier>ISSN: 0748-7983</identifier><identifier>EISSN: 1532-2157</identifier><identifier>DOI: 10.1053/ejso.2001.1222</identifier><identifier>PMID: 11884050</identifier><identifier>CODEN: EJSOE7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>adenocarcinoma ; Adenocarcinoma - mortality ; Adenocarcinoma - secondary ; Adenocarcinoma - therapy ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biopsy, Needle ; Carcinoma, Large Cell - mortality ; Carcinoma, Large Cell - secondary ; Carcinoma, Large Cell - therapy ; cervical metastasis ; Combined Modality Therapy ; diagnosis ; Female ; Head and Neck Neoplasms - mortality ; Head and Neck Neoplasms - secondary ; Head and Neck Neoplasms - therapy ; Humans ; large cell undifferentiated carcinoma ; Lymph Nodes - pathology ; Male ; Medical sciences ; Middle Aged ; Neck Dissection - methods ; Neoplasms, Unknown Primary - pathology ; Neoplasms, Unknown Primary - therapy ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Prognosis ; Radiotherapy, Adjuvant ; Retrospective Studies ; Survival Analysis ; treatment ; Treatment Outcome ; Tumors</subject><ispartof>European journal of surgical oncology, 2002-03, Vol.28 (2), p.147-152</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Harcourt Publishers Limited.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-83842a27d5cfe8e3006983fa43b8395105bf0d6627ea170e667f7a08c48ad2e93</citedby><cites>FETCH-LOGICAL-c436t-83842a27d5cfe8e3006983fa43b8395105bf0d6627ea170e667f7a08c48ad2e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1053/ejso.2001.1222$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=13583868$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11884050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zuur, C.L.</creatorcontrib><creatorcontrib>van Velthuysen, M.L.F.</creatorcontrib><creatorcontrib>Schornagel, J.H.</creatorcontrib><creatorcontrib>Hilgers, F.J.M.</creatorcontrib><creatorcontrib>Balm, A.J.M.</creatorcontrib><title>Diagnosis and treatment of isolated neck metastases of adenocarcinomas</title><title>European journal of surgical oncology</title><addtitle>Eur J Surg Oncol</addtitle><description>Aims: Cervical metastases of adenocarcinoma or undifferentiated large cell carcinoma (ULCC) (non-squamous cell carcinoma) of unknown primary origin are rare and often accompanied by distant metastases at multiple sites in the body. Nevertheless, in the past decades, several patients have presented in our clinic with isolated neck metastases of this type of malignancy. The aim of our study is to evaluate the clinical behaviour of these cases and to define the role of surgery and radiotherapy. Methods: Over the past 24 years, we selected 15 out of 270 patients (6%) with isolated cervical lymph node metastases of adenocarcinoma (six) or ULCC (nine) of unknown primary origin. Diagnosis was made either by histology or by fine needle aspiration cytology. Treatment consisted of (selective) neck dissection and/or radiotherapy. Results: The clinical presentation of isolated cervical metastases of adenocarcinoma compared with ULCC is equivalent, with an overall median survival time of 25 months (confidence interval 21–29 months). Combined therapy was correlated with an increased and persistent regional control and was associated with longer duration of survival. Conclusions: Patients with isolated cervical neck node metastases of adenocarcinoma or ULCC of unknown primary origin are rare and the diagnostic process to identify this subgroup requires a systemic work-up. In selected cases treatment should concentrate on (selective) neck dissection combined with radiotherapy to achieve a prolonged survival.</description><subject>adenocarcinoma</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - secondary</subject><subject>Adenocarcinoma - therapy</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>Carcinoma, Large Cell - mortality</subject><subject>Carcinoma, Large Cell - secondary</subject><subject>Carcinoma, Large Cell - therapy</subject><subject>cervical metastasis</subject><subject>Combined Modality Therapy</subject><subject>diagnosis</subject><subject>Female</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Head and Neck Neoplasms - secondary</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Humans</subject><subject>large cell undifferentiated carcinoma</subject><subject>Lymph Nodes - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neck Dissection - methods</subject><subject>Neoplasms, Unknown Primary - pathology</subject><subject>Neoplasms, Unknown Primary - therapy</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prognosis</subject><subject>Radiotherapy, Adjuvant</subject><subject>Retrospective Studies</subject><subject>Survival Analysis</subject><subject>treatment</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0748-7983</issn><issn>1532-2157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFv1TAMgCMEYo_BlSPqhd36cJK2SY9oMECaxIWdI7_ERRltMuI-pP17Ur0n7TTJsg_-bNmfEO8l7CX0-hPdc94rALmXSqkXYid7rVole_NS7MB0tjWj1RfiDfM9AIzajK_FhZTWdtDDTtx8ifg7ZY7cYArNWgjXhdLa5KmJnGdcKTSJ_J9moRW5BvHWw0Apeyw-prwgvxWvJpyZ3p3rpbi7-frr-nt7-_Pbj-vPt63v9LC2VttOoTKh9xNZ0gBDvW7CTh-sHvv60WGCMAzKEEoDNAxmMgjWdxaDolFfiqvT3oeS_x6JV7dE9jTPmCgf2RnZA9RUwf0J9CUzF5rcQ4kLlkcnwW3m3GbObebcZq4OfDhvPh4WCk_4WVUFPp4BZI_zVDD5yE-c7ut3g62cPXFUPfyLVBz7SMlTiIX86kKOz93wH2nHiW4</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Zuur, C.L.</creator><creator>van Velthuysen, M.L.F.</creator><creator>Schornagel, J.H.</creator><creator>Hilgers, F.J.M.</creator><creator>Balm, A.J.M.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Diagnosis and treatment of isolated neck metastases of adenocarcinomas</title><author>Zuur, C.L. ; van Velthuysen, M.L.F. ; Schornagel, J.H. ; Hilgers, F.J.M. ; Balm, A.J.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-83842a27d5cfe8e3006983fa43b8395105bf0d6627ea170e667f7a08c48ad2e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>adenocarcinoma</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - secondary</topic><topic>Adenocarcinoma - therapy</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>Carcinoma, Large Cell - mortality</topic><topic>Carcinoma, Large Cell - secondary</topic><topic>Carcinoma, Large Cell - therapy</topic><topic>cervical metastasis</topic><topic>Combined Modality Therapy</topic><topic>diagnosis</topic><topic>Female</topic><topic>Head and Neck Neoplasms - mortality</topic><topic>Head and Neck Neoplasms - secondary</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Humans</topic><topic>large cell undifferentiated carcinoma</topic><topic>Lymph Nodes - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neck Dissection - methods</topic><topic>Neoplasms, Unknown Primary - pathology</topic><topic>Neoplasms, Unknown Primary - therapy</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Prognosis</topic><topic>Radiotherapy, Adjuvant</topic><topic>Retrospective Studies</topic><topic>Survival Analysis</topic><topic>treatment</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zuur, C.L.</creatorcontrib><creatorcontrib>van Velthuysen, M.L.F.</creatorcontrib><creatorcontrib>Schornagel, J.H.</creatorcontrib><creatorcontrib>Hilgers, F.J.M.</creatorcontrib><creatorcontrib>Balm, A.J.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zuur, C.L.</au><au>van Velthuysen, M.L.F.</au><au>Schornagel, J.H.</au><au>Hilgers, F.J.M.</au><au>Balm, A.J.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnosis and treatment of isolated neck metastases of adenocarcinomas</atitle><jtitle>European journal of surgical oncology</jtitle><addtitle>Eur J Surg Oncol</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>28</volume><issue>2</issue><spage>147</spage><epage>152</epage><pages>147-152</pages><issn>0748-7983</issn><eissn>1532-2157</eissn><coden>EJSOE7</coden><abstract>Aims: Cervical metastases of adenocarcinoma or undifferentiated large cell carcinoma (ULCC) (non-squamous cell carcinoma) of unknown primary origin are rare and often accompanied by distant metastases at multiple sites in the body. Nevertheless, in the past decades, several patients have presented in our clinic with isolated neck metastases of this type of malignancy. The aim of our study is to evaluate the clinical behaviour of these cases and to define the role of surgery and radiotherapy. Methods: Over the past 24 years, we selected 15 out of 270 patients (6%) with isolated cervical lymph node metastases of adenocarcinoma (six) or ULCC (nine) of unknown primary origin. Diagnosis was made either by histology or by fine needle aspiration cytology. Treatment consisted of (selective) neck dissection and/or radiotherapy. Results: The clinical presentation of isolated cervical metastases of adenocarcinoma compared with ULCC is equivalent, with an overall median survival time of 25 months (confidence interval 21–29 months). Combined therapy was correlated with an increased and persistent regional control and was associated with longer duration of survival. Conclusions: Patients with isolated cervical neck node metastases of adenocarcinoma or ULCC of unknown primary origin are rare and the diagnostic process to identify this subgroup requires a systemic work-up. In selected cases treatment should concentrate on (selective) neck dissection combined with radiotherapy to achieve a prolonged survival.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>11884050</pmid><doi>10.1053/ejso.2001.1222</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0748-7983
ispartof European journal of surgical oncology, 2002-03, Vol.28 (2), p.147-152
issn 0748-7983
1532-2157
language eng
recordid cdi_proquest_miscellaneous_71500715
source MEDLINE; ScienceDirect Journals (5 years ago - present)
subjects adenocarcinoma
Adenocarcinoma - mortality
Adenocarcinoma - secondary
Adenocarcinoma - therapy
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biopsy, Needle
Carcinoma, Large Cell - mortality
Carcinoma, Large Cell - secondary
Carcinoma, Large Cell - therapy
cervical metastasis
Combined Modality Therapy
diagnosis
Female
Head and Neck Neoplasms - mortality
Head and Neck Neoplasms - secondary
Head and Neck Neoplasms - therapy
Humans
large cell undifferentiated carcinoma
Lymph Nodes - pathology
Male
Medical sciences
Middle Aged
Neck Dissection - methods
Neoplasms, Unknown Primary - pathology
Neoplasms, Unknown Primary - therapy
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
Prognosis
Radiotherapy, Adjuvant
Retrospective Studies
Survival Analysis
treatment
Treatment Outcome
Tumors
title Diagnosis and treatment of isolated neck metastases of adenocarcinomas
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T10%3A19%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Diagnosis%20and%20treatment%20of%20isolated%20neck%20metastases%20of%20adenocarcinomas&rft.jtitle=European%20journal%20of%20surgical%20oncology&rft.au=Zuur,%20C.L.&rft.date=2002-03-01&rft.volume=28&rft.issue=2&rft.spage=147&rft.epage=152&rft.pages=147-152&rft.issn=0748-7983&rft.eissn=1532-2157&rft.coden=EJSOE7&rft_id=info:doi/10.1053/ejso.2001.1222&rft_dat=%3Cproquest_cross%3E71500715%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71500715&rft_id=info:pmid/11884050&rft_els_id=S0748798301912223&rfr_iscdi=true