Significance of microvascular density (MVD) in cervical cancer recurrence
. The purpose of this retrospective study of 118 patients with squamous cell cervical cancer from January 1990 to December 1993 was to evaluate angiogenesis as predictive factor of recurrence in cervical cancer stages II–III treated with standard radiotherapy. Microvessel density (MVD) was evaluated...
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| Veröffentlicht in: | International journal of gynecological cancer 2003-11, Vol.13 (6), p.856-862 |
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| container_title | International journal of gynecological cancer |
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| creator | Cantu De León, D. Lopez‐Graniel, C. Frias Mendivil, M. Chanona Vilchis, G. Gomez, C. De La Garza Salazar, J. |
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The purpose of this retrospective study of 118 patients with squamous cell cervical cancer from January 1990 to December 1993 was to evaluate angiogenesis as predictive factor of recurrence in cervical cancer stages II–III treated with standard radiotherapy. Microvessel density (MVD) was evaluated and correlated with other prognostic factors. MVD was greater than 20 in 67.8% of patients with recurrence (P = 0.002) in comparison to 39% of patients without. Disease‐free survival was shorter in stage IIA and MVD >20 (P = 0.0193) as well as for stage IIB (P 20 (P = 0.0316). For stage IIA and MVD >20 survival was shorter (P = 0.0008) for stage IIB (P 20 had poorer disease‐free interval and survival (P = 0.0029). MVD in patients with squamous cell cervical cancer stage II and age younger than 40 may play a role in predicting recurrence and survival. |
| doi_str_mv | 10.1111/j.1525-1438.2003.13399.x |
| format | Article |
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The purpose of this retrospective study of 118 patients with squamous cell cervical cancer from January 1990 to December 1993 was to evaluate angiogenesis as predictive factor of recurrence in cervical cancer stages II–III treated with standard radiotherapy. Microvessel density (MVD) was evaluated and correlated with other prognostic factors. MVD was greater than 20 in 67.8% of patients with recurrence (P = 0.002) in comparison to 39% of patients without. Disease‐free survival was shorter in stage IIA and MVD >20 (P = 0.0193) as well as for stage IIB (P < 0.05 ), but not for IIIB (P = 0.1613 ). Global survival was significantly shorter when MVD was >20 (P = 0.0316). For stage IIA and MVD >20 survival was shorter (P = 0.0008) for stage IIB (P < 0.05) but not for IIIB (P = 0.14) . Patients younger than 40 years and MVD >20 had poorer disease‐free interval and survival (P = 0.0029). MVD in patients with squamous cell cervical cancer stage II and age younger than 40 may play a role in predicting recurrence and survival.</description><identifier>ISSN: 1048-891X</identifier><identifier>EISSN: 1525-1438</identifier><identifier>DOI: 10.1111/j.1525-1438.2003.13399.x</identifier><identifier>PMID: 14675324</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Inc</publisher><subject>Adult ; Age Factors ; Aged ; angiogenesis ; Carcinoma, Squamous Cell - blood supply ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - radiotherapy ; cervical cancer ; Disease-Free Survival ; Female ; Humans ; locally advanced ; Microcirculation ; Middle Aged ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Neovascularization, Pathologic ; Retrospective Studies ; Risk Factors ; Uterine Cervical Neoplasms - blood supply ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - radiotherapy</subject><ispartof>International journal of gynecological cancer, 2003-11, Vol.13 (6), p.856-862</ispartof><rights>2003 Blackwell Science Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4778-a2d074120f5a5593a225ec9b59afa88f00f47c24996caa2bc838ae468c2401fd3</citedby><cites>FETCH-LOGICAL-c4778-a2d074120f5a5593a225ec9b59afa88f00f47c24996caa2bc838ae468c2401fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1525-1438.2003.13399.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1525-1438.2003.13399.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14675324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cantu De León, D.</creatorcontrib><creatorcontrib>Lopez‐Graniel, C.</creatorcontrib><creatorcontrib>Frias Mendivil, M.</creatorcontrib><creatorcontrib>Chanona Vilchis, G.</creatorcontrib><creatorcontrib>Gomez, C.</creatorcontrib><creatorcontrib>De La Garza Salazar, J.</creatorcontrib><title>Significance of microvascular density (MVD) in cervical cancer recurrence</title><title>International journal of gynecological cancer</title><addtitle>Int J Gynecol Cancer</addtitle><description>.
The purpose of this retrospective study of 118 patients with squamous cell cervical cancer from January 1990 to December 1993 was to evaluate angiogenesis as predictive factor of recurrence in cervical cancer stages II–III treated with standard radiotherapy. Microvessel density (MVD) was evaluated and correlated with other prognostic factors. MVD was greater than 20 in 67.8% of patients with recurrence (P = 0.002) in comparison to 39% of patients without. Disease‐free survival was shorter in stage IIA and MVD >20 (P = 0.0193) as well as for stage IIB (P < 0.05 ), but not for IIIB (P = 0.1613 ). Global survival was significantly shorter when MVD was >20 (P = 0.0316). For stage IIA and MVD >20 survival was shorter (P = 0.0008) for stage IIB (P < 0.05) but not for IIIB (P = 0.14) . Patients younger than 40 years and MVD >20 had poorer disease‐free interval and survival (P = 0.0029). MVD in patients with squamous cell cervical cancer stage II and age younger than 40 may play a role in predicting recurrence and survival.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>angiogenesis</subject><subject>Carcinoma, Squamous Cell - blood supply</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>cervical cancer</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>locally advanced</subject><subject>Microcirculation</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neoplasm Staging</subject><subject>Neovascularization, Pathologic</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Uterine Cervical Neoplasms - blood supply</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - radiotherapy</subject><issn>1048-891X</issn><issn>1525-1438</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF9PHCEUxYmpUWv9CoYn0z7MyN8FXpo0trXbaHyoNn0jLHupbNkZhR11v32Z3Y19LQnhAOfcCz-EMCUtreN80VLJZEMF1y0jhLeUc2Palz109HrxpmoidKMN_XWI3payIIQYRswBOqRioiRn4ghNf8TfXQzRu84D7gNeRp_7J1f8kFzGc-hKXK3x--ufnz_g2GEP-amaE94EMs7gh5yh6ndoP7hU4GS3HqO7r19uL741VzeX04tPV40XSunGsTlRgjISpJPScMeYBG9m0rjgtA6EBKE8E8ZMvHNs5jXXDsRE1zNCw5wfo7Nt3YfcPw5QVnYZi4eUXAf9UKyikhBqVDXqrbF-qJQMwT7kuHR5bSmxI0a7sCMtO9KyI0a7wWhfavR012OYLWH-L7jjVg1ia3ju0wpy-ZOGZ8j2Hlxa3VsykpZKNWNRSuuuqZPqGvu4i8UE6_9-j51-v9xI_hfZv5Aj</recordid><startdate>200311</startdate><enddate>200311</enddate><creator>Cantu De León, D.</creator><creator>Lopez‐Graniel, C.</creator><creator>Frias Mendivil, M.</creator><creator>Chanona Vilchis, G.</creator><creator>Gomez, C.</creator><creator>De La Garza Salazar, J.</creator><general>Blackwell Science Inc</general><general>Blackwell Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200311</creationdate><title>Significance of microvascular density (MVD) in cervical cancer recurrence</title><author>Cantu De León, D. ; Lopez‐Graniel, C. ; Frias Mendivil, M. ; Chanona Vilchis, G. ; Gomez, C. ; De La Garza Salazar, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4778-a2d074120f5a5593a225ec9b59afa88f00f47c24996caa2bc838ae468c2401fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>angiogenesis</topic><topic>Carcinoma, Squamous Cell - blood supply</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>cervical cancer</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>locally advanced</topic><topic>Microcirculation</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local</topic><topic>Neoplasm Staging</topic><topic>Neovascularization, Pathologic</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Uterine Cervical Neoplasms - blood supply</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterine Cervical Neoplasms - radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cantu De León, D.</creatorcontrib><creatorcontrib>Lopez‐Graniel, C.</creatorcontrib><creatorcontrib>Frias Mendivil, M.</creatorcontrib><creatorcontrib>Chanona Vilchis, G.</creatorcontrib><creatorcontrib>Gomez, C.</creatorcontrib><creatorcontrib>De La Garza Salazar, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecological cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cantu De León, D.</au><au>Lopez‐Graniel, C.</au><au>Frias Mendivil, M.</au><au>Chanona Vilchis, G.</au><au>Gomez, C.</au><au>De La Garza Salazar, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of microvascular density (MVD) in cervical cancer recurrence</atitle><jtitle>International journal of gynecological cancer</jtitle><addtitle>Int J Gynecol Cancer</addtitle><date>2003-11</date><risdate>2003</risdate><volume>13</volume><issue>6</issue><spage>856</spage><epage>862</epage><pages>856-862</pages><issn>1048-891X</issn><eissn>1525-1438</eissn><abstract>.
The purpose of this retrospective study of 118 patients with squamous cell cervical cancer from January 1990 to December 1993 was to evaluate angiogenesis as predictive factor of recurrence in cervical cancer stages II–III treated with standard radiotherapy. Microvessel density (MVD) was evaluated and correlated with other prognostic factors. MVD was greater than 20 in 67.8% of patients with recurrence (P = 0.002) in comparison to 39% of patients without. Disease‐free survival was shorter in stage IIA and MVD >20 (P = 0.0193) as well as for stage IIB (P < 0.05 ), but not for IIIB (P = 0.1613 ). Global survival was significantly shorter when MVD was >20 (P = 0.0316). For stage IIA and MVD >20 survival was shorter (P = 0.0008) for stage IIB (P < 0.05) but not for IIIB (P = 0.14) . Patients younger than 40 years and MVD >20 had poorer disease‐free interval and survival (P = 0.0029). MVD in patients with squamous cell cervical cancer stage II and age younger than 40 may play a role in predicting recurrence and survival.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Inc</pub><pmid>14675324</pmid><doi>10.1111/j.1525-1438.2003.13399.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Age Factors Aged angiogenesis Carcinoma, Squamous Cell - blood supply Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - radiotherapy cervical cancer Disease-Free Survival Female Humans locally advanced Microcirculation Middle Aged Neoplasm Recurrence, Local Neoplasm Staging Neovascularization, Pathologic Retrospective Studies Risk Factors Uterine Cervical Neoplasms - blood supply Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - radiotherapy |
| title | Significance of microvascular density (MVD) in cervical cancer recurrence |
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