Inhibition of adjuvant-induced arthritis by 16 alpha-fluoro-5-androsten-17-one
The adrenal steroid dehydroepiandrosterone (DHEA) produces cancer-preventive, antiatherosclerotic, antidiabetic, immunomodulating, and anti-inflammatory effects in laboratory animals. The clinical use of DHEA is limited by its androgenicity. We have developed a synthetic congener of DHEA called flua...
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| Veröffentlicht in: | Military medicine 2002-02, Vol.167 (2 Suppl), p.60-63 |
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| creator | Schwartz, Arthur G Pashko, Laura L |
| description | The adrenal steroid dehydroepiandrosterone (DHEA) produces cancer-preventive, antiatherosclerotic, antidiabetic, immunomodulating, and anti-inflammatory effects in laboratory animals. The clinical use of DHEA is limited by its androgenicity. We have developed a synthetic congener of DHEA called fluasterone that, in animal tests, lacks the androgenicity, estrogenicity, and peroxisome-proliferating effects of DHEA but retains the cancer-preventive, antidiabetic, and anti-inflammatory efficacy. This report discusses how fluasterone ameliorates the development of joint inflammation in an adjuvant-arthritis model in Lewis rats. |
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| ispartof | Military medicine, 2002-02, Vol.167 (2 Suppl), p.60-63 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Antineoplastic Agents - pharmacology Arthritis, Experimental - drug therapy Dehydroepiandrosterone - analogs & derivatives Dehydroepiandrosterone - pharmacology Female Rats Rats, Inbred Lew |
| title | Inhibition of adjuvant-induced arthritis by 16 alpha-fluoro-5-androsten-17-one |
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