Inhibition of adjuvant-induced arthritis by 16 alpha-fluoro-5-androsten-17-one

The adrenal steroid dehydroepiandrosterone (DHEA) produces cancer-preventive, antiatherosclerotic, antidiabetic, immunomodulating, and anti-inflammatory effects in laboratory animals. The clinical use of DHEA is limited by its androgenicity. We have developed a synthetic congener of DHEA called flua...

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Veröffentlicht in:	Military medicine 2002-02, Vol.167 (2 Suppl), p.60-63
Hauptverfasser:	Schwartz, Arthur G, Pashko, Laura L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Arthritis, Experimental - drug therapy Dehydroepiandrosterone - analogs & derivatives Dehydroepiandrosterone - pharmacology Female Rats Rats, Inbred Lew
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The adrenal steroid dehydroepiandrosterone (DHEA) produces cancer-preventive, antiatherosclerotic, antidiabetic, immunomodulating, and anti-inflammatory effects in laboratory animals. The clinical use of DHEA is limited by its androgenicity. We have developed a synthetic congener of DHEA called fluasterone that, in animal tests, lacks the androgenicity, estrogenicity, and peroxisome-proliferating effects of DHEA but retains the cancer-preventive, antidiabetic, and anti-inflammatory efficacy. This report discusses how fluasterone ameliorates the development of joint inflammation in an adjuvant-arthritis model in Lewis rats.
ISSN:	0026-4075