PULMONARY DEPOSITION OF MONODISPERSE AEROSOLS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
In order to improve patient convenience and drug availability for patients with α 1 -protease inhibitor deficiency, the administration via the inhalation route has been considered. This study investigated if it is possible to obtain high values of peripheral aerosol deposition by using optimized and...
Gespeichert in:
| Veröffentlicht in: | Experimental lung research 2003-10, Vol.29 (7), p.475-484 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 484 |
|---|---|
| container_issue | 7 |
| container_start_page | 475 |
| container_title | Experimental lung research |
| container_volume | 29 |
| creator | Meyer, T. Müllinger, B. Sommerer, K. Scheuch, G. Brand, P. Beckmann, H. Häussinger, K. Weber, N. Siekmeier, R. |
| description | In order to improve patient convenience and drug availability for patients with α 1 -protease inhibitor deficiency, the administration via the inhalation route has been considered. This study investigated if it is possible to obtain high values of peripheral aerosol deposition by using optimized and controlled inhalation conditions. Therefore, peripheral deposition was studied in 10 patients with α 1 -protease inhibitor deficiency (phenotype PiZ) and moderate to severe chronic obstructive pulmonary disease by measuring the 24-hour Clearance of radiolabeled inert iron oxide particles with diameters of 2 μ m, 3 μ m, and 4 μ m. Patients inhaled a large volume of aerosol (1000 to 2000 cm 3) , which was normalized to the individual lung function, with a flow rate of 200 cm 3 /S. Due to this breathing pattern, peripheral deposition was for all particle sizes above 50% of the inhaled aerosol. The highest peripheral deposition (68%) was found for 3-μ m particles. |
| doi_str_mv | 10.1080/01902140303775 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71499907</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71499907</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-6811fd9aff9704ef9f0585d35e6e2cea855bffe21ebcbbb7220e2cab1d85705a3</originalsourceid><addsrcrecordid>eNp1kcFv0zAUhy0EYmVw5Yh8gVvGsxM38TFk3mqpxFWSgjhFTmJrndJms1uh_fd4aqexw06W3vt-Pz19RugzgQsCGXwHwoGSBGKI05S9QTPCKIkg4fwtmj0uo7DNztAH728BgLJs_h6dkSQlkMR8hobVevlTlXn1B1-KlaplI1WJ1RUOQ3Up65WoaoFzUalaLWssS7zKGynKpsa_ZbPAxaJSpSyw-lE31bpo5C-B_6uUtchr8RG9s3r05tPpPUfrK9EUi2iprmWRL6M-obCP5hkhduDaWp5CYiy3wDI2xMzMDe2NzhjrrDWUmK7vui6lFMJcd2TIWApMx-fo27H3zk33B-P37XbjezOOememg29TErxwSAN4cQR7N3nvjG3v3Gar3UNLoH302r70GgJfTs2HbmuGZ_wkMgBfT4D2vR6t07t-45-58Cs0BQgcP3KbnZ3cVv-d3Di0e_0wTu4pFL96RPYie2P0uL_ptTPt7XRwu6D2tfv_Acnqm7g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71499907</pqid></control><display><type>article</type><title>PULMONARY DEPOSITION OF MONODISPERSE AEROSOLS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE</title><source>MEDLINE</source><source>Taylor & Francis Journals Complete</source><creator>Meyer, T. ; Müllinger, B. ; Sommerer, K. ; Scheuch, G. ; Brand, P. ; Beckmann, H. ; Häussinger, K. ; Weber, N. ; Siekmeier, R.</creator><creatorcontrib>Meyer, T. ; Müllinger, B. ; Sommerer, K. ; Scheuch, G. ; Brand, P. ; Beckmann, H. ; Häussinger, K. ; Weber, N. ; Siekmeier, R.</creatorcontrib><description>In order to improve patient convenience and drug availability for patients with α 1 -protease inhibitor deficiency, the administration via the inhalation route has been considered. This study investigated if it is possible to obtain high values of peripheral aerosol deposition by using optimized and controlled inhalation conditions. Therefore, peripheral deposition was studied in 10 patients with α 1 -protease inhibitor deficiency (phenotype PiZ) and moderate to severe chronic obstructive pulmonary disease by measuring the 24-hour Clearance of radiolabeled inert iron oxide particles with diameters of 2 μ m, 3 μ m, and 4 μ m. Patients inhaled a large volume of aerosol (1000 to 2000 cm 3) , which was normalized to the individual lung function, with a flow rate of 200 cm 3 /S. Due to this breathing pattern, peripheral deposition was for all particle sizes above 50% of the inhaled aerosol. The highest peripheral deposition (68%) was found for 3-μ m particles.</description><identifier>ISSN: 0190-2148</identifier><identifier>EISSN: 1521-0499</identifier><identifier>DOI: 10.1080/01902140303775</identifier><identifier>PMID: 14710439</identifier><identifier>CODEN: EXLRDA</identifier><language>eng</language><publisher>Philadelphia, PA: Informa UK Ltd</publisher><subject>Administration, Inhalation ; Aerosol ; Aerosols - administration & dosage ; Aerosols - pharmacokinetics ; alpha 1-Antitrypsin Deficiency - metabolism ; alpha 1-Antitrypsin Deficiency - physiopathology ; Biological and medical sciences ; Chronic Obstructive Pulmonary Disease ; Female ; Ferric Compounds ; Humans ; Inhalation ; Male ; Medical sciences ; Middle Aged ; Particle Size ; Peripheral Deposition ; Pharmacology. Drug treatments ; Pulmonary Alveoli - metabolism ; Pulmonary Disease, Chronic Obstructive - metabolism ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Respiratory Function Tests ; Respiratory system ; Systemic Drug Delivery ; Technetium ; α 1 -proteinase Deficiency</subject><ispartof>Experimental lung research, 2003-10, Vol.29 (7), p.475-484</ispartof><rights>2003 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2003</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-6811fd9aff9704ef9f0585d35e6e2cea855bffe21ebcbbb7220e2cab1d85705a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/01902140303775$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/01902140303775$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,60436,61221,61402</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15212700$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14710439$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meyer, T.</creatorcontrib><creatorcontrib>Müllinger, B.</creatorcontrib><creatorcontrib>Sommerer, K.</creatorcontrib><creatorcontrib>Scheuch, G.</creatorcontrib><creatorcontrib>Brand, P.</creatorcontrib><creatorcontrib>Beckmann, H.</creatorcontrib><creatorcontrib>Häussinger, K.</creatorcontrib><creatorcontrib>Weber, N.</creatorcontrib><creatorcontrib>Siekmeier, R.</creatorcontrib><title>PULMONARY DEPOSITION OF MONODISPERSE AEROSOLS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE</title><title>Experimental lung research</title><addtitle>Exp Lung Res</addtitle><description>In order to improve patient convenience and drug availability for patients with α 1 -protease inhibitor deficiency, the administration via the inhalation route has been considered. This study investigated if it is possible to obtain high values of peripheral aerosol deposition by using optimized and controlled inhalation conditions. Therefore, peripheral deposition was studied in 10 patients with α 1 -protease inhibitor deficiency (phenotype PiZ) and moderate to severe chronic obstructive pulmonary disease by measuring the 24-hour Clearance of radiolabeled inert iron oxide particles with diameters of 2 μ m, 3 μ m, and 4 μ m. Patients inhaled a large volume of aerosol (1000 to 2000 cm 3) , which was normalized to the individual lung function, with a flow rate of 200 cm 3 /S. Due to this breathing pattern, peripheral deposition was for all particle sizes above 50% of the inhaled aerosol. The highest peripheral deposition (68%) was found for 3-μ m particles.</description><subject>Administration, Inhalation</subject><subject>Aerosol</subject><subject>Aerosols - administration & dosage</subject><subject>Aerosols - pharmacokinetics</subject><subject>alpha 1-Antitrypsin Deficiency - metabolism</subject><subject>alpha 1-Antitrypsin Deficiency - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Chronic Obstructive Pulmonary Disease</subject><subject>Female</subject><subject>Ferric Compounds</subject><subject>Humans</subject><subject>Inhalation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Particle Size</subject><subject>Peripheral Deposition</subject><subject>Pharmacology. Drug treatments</subject><subject>Pulmonary Alveoli - metabolism</subject><subject>Pulmonary Disease, Chronic Obstructive - metabolism</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Respiratory Function Tests</subject><subject>Respiratory system</subject><subject>Systemic Drug Delivery</subject><subject>Technetium</subject><subject>α 1 -proteinase Deficiency</subject><issn>0190-2148</issn><issn>1521-0499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFv0zAUhy0EYmVw5Yh8gVvGsxM38TFk3mqpxFWSgjhFTmJrndJms1uh_fd4aqexw06W3vt-Pz19RugzgQsCGXwHwoGSBGKI05S9QTPCKIkg4fwtmj0uo7DNztAH728BgLJs_h6dkSQlkMR8hobVevlTlXn1B1-KlaplI1WJ1RUOQ3Up65WoaoFzUalaLWssS7zKGynKpsa_ZbPAxaJSpSyw-lE31bpo5C-B_6uUtchr8RG9s3r05tPpPUfrK9EUi2iprmWRL6M-obCP5hkhduDaWp5CYiy3wDI2xMzMDe2NzhjrrDWUmK7vui6lFMJcd2TIWApMx-fo27H3zk33B-P37XbjezOOememg29TErxwSAN4cQR7N3nvjG3v3Gar3UNLoH302r70GgJfTs2HbmuGZ_wkMgBfT4D2vR6t07t-45-58Cs0BQgcP3KbnZ3cVv-d3Di0e_0wTu4pFL96RPYie2P0uL_ptTPt7XRwu6D2tfv_Acnqm7g</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>Meyer, T.</creator><creator>Müllinger, B.</creator><creator>Sommerer, K.</creator><creator>Scheuch, G.</creator><creator>Brand, P.</creator><creator>Beckmann, H.</creator><creator>Häussinger, K.</creator><creator>Weber, N.</creator><creator>Siekmeier, R.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>PULMONARY DEPOSITION OF MONODISPERSE AEROSOLS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE</title><author>Meyer, T. ; Müllinger, B. ; Sommerer, K. ; Scheuch, G. ; Brand, P. ; Beckmann, H. ; Häussinger, K. ; Weber, N. ; Siekmeier, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-6811fd9aff9704ef9f0585d35e6e2cea855bffe21ebcbbb7220e2cab1d85705a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Administration, Inhalation</topic><topic>Aerosol</topic><topic>Aerosols - administration & dosage</topic><topic>Aerosols - pharmacokinetics</topic><topic>alpha 1-Antitrypsin Deficiency - metabolism</topic><topic>alpha 1-Antitrypsin Deficiency - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Chronic Obstructive Pulmonary Disease</topic><topic>Female</topic><topic>Ferric Compounds</topic><topic>Humans</topic><topic>Inhalation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Particle Size</topic><topic>Peripheral Deposition</topic><topic>Pharmacology. Drug treatments</topic><topic>Pulmonary Alveoli - metabolism</topic><topic>Pulmonary Disease, Chronic Obstructive - metabolism</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Respiratory Function Tests</topic><topic>Respiratory system</topic><topic>Systemic Drug Delivery</topic><topic>Technetium</topic><topic>α 1 -proteinase Deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meyer, T.</creatorcontrib><creatorcontrib>Müllinger, B.</creatorcontrib><creatorcontrib>Sommerer, K.</creatorcontrib><creatorcontrib>Scheuch, G.</creatorcontrib><creatorcontrib>Brand, P.</creatorcontrib><creatorcontrib>Beckmann, H.</creatorcontrib><creatorcontrib>Häussinger, K.</creatorcontrib><creatorcontrib>Weber, N.</creatorcontrib><creatorcontrib>Siekmeier, R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental lung research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meyer, T.</au><au>Müllinger, B.</au><au>Sommerer, K.</au><au>Scheuch, G.</au><au>Brand, P.</au><au>Beckmann, H.</au><au>Häussinger, K.</au><au>Weber, N.</au><au>Siekmeier, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PULMONARY DEPOSITION OF MONODISPERSE AEROSOLS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE</atitle><jtitle>Experimental lung research</jtitle><addtitle>Exp Lung Res</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>29</volume><issue>7</issue><spage>475</spage><epage>484</epage><pages>475-484</pages><issn>0190-2148</issn><eissn>1521-0499</eissn><coden>EXLRDA</coden><abstract>In order to improve patient convenience and drug availability for patients with α 1 -protease inhibitor deficiency, the administration via the inhalation route has been considered. This study investigated if it is possible to obtain high values of peripheral aerosol deposition by using optimized and controlled inhalation conditions. Therefore, peripheral deposition was studied in 10 patients with α 1 -protease inhibitor deficiency (phenotype PiZ) and moderate to severe chronic obstructive pulmonary disease by measuring the 24-hour Clearance of radiolabeled inert iron oxide particles with diameters of 2 μ m, 3 μ m, and 4 μ m. Patients inhaled a large volume of aerosol (1000 to 2000 cm 3) , which was normalized to the individual lung function, with a flow rate of 200 cm 3 /S. Due to this breathing pattern, peripheral deposition was for all particle sizes above 50% of the inhaled aerosol. The highest peripheral deposition (68%) was found for 3-μ m particles.</abstract><cop>Philadelphia, PA</cop><pub>Informa UK Ltd</pub><pmid>14710439</pmid><doi>10.1080/01902140303775</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0190-2148 |
| ispartof | Experimental lung research, 2003-10, Vol.29 (7), p.475-484 |
| issn | 0190-2148 1521-0499 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71499907 |
| source | MEDLINE; Taylor & Francis Journals Complete |
| subjects | Administration, Inhalation Aerosol Aerosols - administration & dosage Aerosols - pharmacokinetics alpha 1-Antitrypsin Deficiency - metabolism alpha 1-Antitrypsin Deficiency - physiopathology Biological and medical sciences Chronic Obstructive Pulmonary Disease Female Ferric Compounds Humans Inhalation Male Medical sciences Middle Aged Particle Size Peripheral Deposition Pharmacology. Drug treatments Pulmonary Alveoli - metabolism Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Disease, Chronic Obstructive - physiopathology Respiratory Function Tests Respiratory system Systemic Drug Delivery Technetium α 1 -proteinase Deficiency |
| title | PULMONARY DEPOSITION OF MONODISPERSE AEROSOLS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T22%3A48%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PULMONARY%20DEPOSITION%20OF%20MONODISPERSE%20AEROSOLS%20IN%20PATIENTS%20WITH%20CHRONIC%20OBSTRUCTIVE%20PULMONARY%20DISEASE&rft.jtitle=Experimental%20lung%20research&rft.au=Meyer,%20T.&rft.date=2003-10-01&rft.volume=29&rft.issue=7&rft.spage=475&rft.epage=484&rft.pages=475-484&rft.issn=0190-2148&rft.eissn=1521-0499&rft.coden=EXLRDA&rft_id=info:doi/10.1080/01902140303775&rft_dat=%3Cproquest_cross%3E71499907%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71499907&rft_id=info:pmid/14710439&rfr_iscdi=true |