A Theoretical Limit to Coding Space in Chromosomes of Bacteria
A mathematical model of cluster patterns for mapped genes with known phenotypes in Escherichia coli predicted that functional genes may account for a maximum of two-thirds of the total chromosomal space. The corollary prediction was that one-third of the chromosome comprised noncoding space. Open re...
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| Veröffentlicht in: | Omics (Larchmont, N.Y.) N.Y.), 2002-01, Vol.6 (1), p.115-121 |
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| container_title | Omics (Larchmont, N.Y.) |
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| creator | Jackson, Julius H. Harrison, Scott H. Herring, Patricia A. |
| description | A mathematical model of cluster patterns for mapped genes with known phenotypes in
Escherichia coli
predicted that
functional genes
may account for a maximum of two-thirds of the total chromosomal
space. The corollary prediction was that one-third of the chromosome comprised noncoding space. Open reading frame (ORF) analyses for 15 phylogenetically diverse bacterial genomes and for 30 fully sequenced
prokaryotic genomes supported the gene cluster model prediction of a two-thirds tendency for coding space. Our results suggest that only 3-4% of unassigned ORFs in
E. coli
represent genes with potential
phenotype and that ORFs marking novel genes in prokaryotes are far fewer than previously thought. |
| doi_str_mv | 10.1089/15362310252780861 |
| format | Article |
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Escherichia coli
predicted that
functional genes
may account for a maximum of two-thirds of the total chromosomal
space. The corollary prediction was that one-third of the chromosome comprised noncoding space. Open reading frame (ORF) analyses for 15 phylogenetically diverse bacterial genomes and for 30 fully sequenced
prokaryotic genomes supported the gene cluster model prediction of a two-thirds tendency for coding space. Our results suggest that only 3-4% of unassigned ORFs in
E. coli
represent genes with potential
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Escherichia coli
predicted that
functional genes
may account for a maximum of two-thirds of the total chromosomal
space. The corollary prediction was that one-third of the chromosome comprised noncoding space. Open reading frame (ORF) analyses for 15 phylogenetically diverse bacterial genomes and for 30 fully sequenced
prokaryotic genomes supported the gene cluster model prediction of a two-thirds tendency for coding space. Our results suggest that only 3-4% of unassigned ORFs in
E. coli
represent genes with potential
phenotype and that ORFs marking novel genes in prokaryotes are far fewer than previously thought.</description><subject>Chromosomes, Bacterial</subject><subject>Escherichia coli - genetics</subject><subject>Open Reading Frames</subject><subject>Phenotype</subject><subject>Phylogeny</subject><issn>1536-2310</issn><issn>1557-8100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkDtPwzAUhS0EolD4ASzIE1vA13nYXpBKxEuqxECZI8e5oUZJXGx34N-TqJUYGGA6V0ffOdI9hFwAuwYm1Q3kacFTYDznQjJZwAE5gTwXiQTGDqc7LZIJmJHTED4Y4zDyx2QGICVIrk7I7YKu1ug8Rmt0R5e2t5FGR0vX2OGdvm60QWoHWq69611wPQbqWnqnTURv9Rk5anUX8Hyvc_L2cL8qn5Lly-NzuVgmhiuICecsl6zVmcgzo3ktW84LrYxhxtStVG3WjGadqkZpMQoCNrWAGsa3MpPLdE6udr0b7z63GGLV22Cw6_SAbhsqAZmSCsSfIMgMmEj5CMIONN6F4LGtNt722n9VwKpp3erXumPmcl--rXtsfhL7OUdA7IDJ1sPQWazRx39UfwNIwIPl</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Jackson, Julius H.</creator><creator>Harrison, Scott H.</creator><creator>Herring, Patricia A.</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>A Theoretical Limit to Coding Space in Chromosomes of Bacteria</title><author>Jackson, Julius H. ; Harrison, Scott H. ; Herring, Patricia A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c291t-220580fa4754ca2b8f226a9cc0ccbf89f4d2b8b39d9a7b39e1edb71b17804c583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Chromosomes, Bacterial</topic><topic>Escherichia coli - genetics</topic><topic>Open Reading Frames</topic><topic>Phenotype</topic><topic>Phylogeny</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jackson, Julius H.</creatorcontrib><creatorcontrib>Harrison, Scott H.</creatorcontrib><creatorcontrib>Herring, Patricia A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Omics (Larchmont, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jackson, Julius H.</au><au>Harrison, Scott H.</au><au>Herring, Patricia A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Theoretical Limit to Coding Space in Chromosomes of Bacteria</atitle><jtitle>Omics (Larchmont, N.Y.)</jtitle><addtitle>OMICS</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>6</volume><issue>1</issue><spage>115</spage><epage>121</epage><pages>115-121</pages><issn>1536-2310</issn><eissn>1557-8100</eissn><abstract>A mathematical model of cluster patterns for mapped genes with known phenotypes in
Escherichia coli
predicted that
functional genes
may account for a maximum of two-thirds of the total chromosomal
space. The corollary prediction was that one-third of the chromosome comprised noncoding space. Open reading frame (ORF) analyses for 15 phylogenetically diverse bacterial genomes and for 30 fully sequenced
prokaryotic genomes supported the gene cluster model prediction of a two-thirds tendency for coding space. Our results suggest that only 3-4% of unassigned ORFs in
E. coli
represent genes with potential
phenotype and that ORFs marking novel genes in prokaryotes are far fewer than previously thought.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>11881829</pmid><doi>10.1089/15362310252780861</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 1536-2310 |
| ispartof | Omics (Larchmont, N.Y.), 2002-01, Vol.6 (1), p.115-121 |
| issn | 1536-2310 1557-8100 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71498917 |
| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | Chromosomes, Bacterial Escherichia coli - genetics Open Reading Frames Phenotype Phylogeny |
| title | A Theoretical Limit to Coding Space in Chromosomes of Bacteria |
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