Multiple mechanisms in indomethacin-induced impairment of hepatic cytochrome p450 enzymes in rats

Indomethacin impairs liver microsomal monooxygenase activities mediated by cytochrome P450 (CYP). We investigated the inhibition mechanism and the isoform selectivity in vitro and in vivo. In an in vitro study, liver microsomes from male Wistar rats were preincubated with indomethacin and a reduced...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2002-03, Vol.122 (3), p.774-783
Hauptverfasser:	Masubuchi, Yasuhiro, Masuda, Emi, Horie, Toshiharu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Aryl Hydrocarbon Hydroxylases Biological and medical sciences Carbon Radioisotopes Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - metabolism Enzyme Activation - drug effects General pharmacology In Vitro Techniques Indomethacin - pharmacology Inflammation Mediators - metabolism Kupffer Cells - enzymology Kupffer Cells - immunology Liver - enzymology Liver - immunology Male Medical sciences Membrane Proteins Microsomes, Liver - enzymology NADP - metabolism Nitrates - blood Nitric Oxide - biosynthesis Nitrites - blood Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Rats Rats, Wistar Steroid 16-alpha-Hydroxylase Steroid Hydroxylases - metabolism
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