Covalent Attachment of the SUMO-1 Protein to the Negative Regulatory Domain of the c-Myb Transcription Factor Modifies Its Stability and Transactivation Capacity

The transcription factor c-Myb is subject to several types of post-translational modifications, including phosphorylation, acetylation, and ubiquitination. These modifications regulate the transcription and transforming activity as well as the proteolytic stability of c-Myb. Here we report the coval...

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Veröffentlicht in:	The Journal of biological chemistry 2002-03, Vol.277 (11), p.8999-9009
Hauptverfasser:	Bies, Juraj, Markus, Ján, Wolff, Linda
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals c-Myb protein Cell Line Mice Phosphorylation Protein Processing, Post-Translational Proto-Oncogene Proteins c-myb - chemistry Proto-Oncogene Proteins c-myb - physiology Serine - metabolism SUMO-1 protein SUMO-1 Protein - metabolism Trans-Activators - physiology
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