Phosphoproteomic fingerprinting of epidermal growth factor signaling and anticancer drug action in human tumor cells

Many proteins regulating cancer cell growth are tyrosine phosphorylated. Using antiphosphotyrosine affinity chromatography, thiourea protein solubilization, two-dimensional PAGE, and mass spectrometry, we report here the characterization of the epidermal growth factor (EGF)-induced phosphoproteome i...

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Veröffentlicht in:	Molecular cancer therapeutics 2003-12, Vol.2 (12), p.1369-1377
Hauptverfasser:	Lim, Yoon-Pin, Diong, Lang-Shi, Qi, Robert, Druker, Brian J, Epstein, Richard J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Cell Line, Tumor Chromatography, Affinity Electrophoresis, Gel, Two-Dimensional Epidermal Growth Factor - metabolism Humans Ligands Mass Spectrometry Phosphoproteins - metabolism Proteome Signal Transduction Tyrosine - metabolism
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