Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure
To assess urinary 6-sulfatoxymelatonin excretion in patients admitted to the hospital because of congestive heart failure (CHF). Urinary 6-sulfatoxymelatonin was measured by a specific radioimmunoassay in 33 hospitalized patients with CHF and in 146 healthy ambulatory volunteers. Individuals with he...
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| Veröffentlicht in: | Endocrine 2003-12, Vol.22 (3), p.245-248 |
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| container_title | Endocrine |
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| creator | Girotti, Luis Lago, Manuel Ianovsky, Oscar Elizari, Marcelo V Dini, Andrés Pérez Lloret, Santiago Albornoz, Liliana E Cardinali, Daniel P |
| description | To assess urinary 6-sulfatoxymelatonin excretion in patients admitted to the hospital because of congestive heart failure (CHF).
Urinary 6-sulfatoxymelatonin was measured by a specific radioimmunoassay in 33 hospitalized patients with CHF and in 146 healthy ambulatory volunteers. Individuals with hepatic or renal failure were excluded from the sample. Data were analyzed by the Mann-Whitney test and regression analysis.
6-Sulfatoxymelatonin levels were significantly lower in CHF patients than controls (median 2.6 vs 6.02 microg, p < 0.0001). This decrease was observed regardless of beta-adrenergic blocker or benzodiazepine medication. A significant decrease in 6-sulfatoxymelatonin excretion occurred with age. There were no significant differences in urinary 6-sulfatoxymelatonin levels between chronic and acute CHF patients.
The results suggest that circulating melatonin levels are low in patients with CHF. Such a decrease may precede aggravation of heart failure. |
| doi_str_mv | 10.1385/ENDO:22:3:245 |
| format | Article |
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Urinary 6-sulfatoxymelatonin was measured by a specific radioimmunoassay in 33 hospitalized patients with CHF and in 146 healthy ambulatory volunteers. Individuals with hepatic or renal failure were excluded from the sample. Data were analyzed by the Mann-Whitney test and regression analysis.
6-Sulfatoxymelatonin levels were significantly lower in CHF patients than controls (median 2.6 vs 6.02 microg, p < 0.0001). This decrease was observed regardless of beta-adrenergic blocker or benzodiazepine medication. A significant decrease in 6-sulfatoxymelatonin excretion occurred with age. There were no significant differences in urinary 6-sulfatoxymelatonin levels between chronic and acute CHF patients.
The results suggest that circulating melatonin levels are low in patients with CHF. Such a decrease may precede aggravation of heart failure.</description><identifier>ISSN: 1355-008X</identifier><identifier>ISSN: 0969-711X</identifier><identifier>EISSN: 0969-711X</identifier><identifier>DOI: 10.1385/ENDO:22:3:245</identifier><identifier>PMID: 14709797</identifier><language>eng</language><publisher>United States</publisher><subject>Adrenergic beta-Antagonists - therapeutic use ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Benzodiazepines - therapeutic use ; Female ; Heart Failure - drug therapy ; Heart Failure - metabolism ; Heart Failure - urine ; Humans ; Male ; Melatonin - analogs & derivatives ; Melatonin - metabolism ; Melatonin - urine ; Middle Aged</subject><ispartof>Endocrine, 2003-12, Vol.22 (3), p.245-248</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c289t-89a53188676c31c8557602679cc595327e65d8da355610a14a2dcd46d1d9f6ba3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14709797$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Girotti, Luis</creatorcontrib><creatorcontrib>Lago, Manuel</creatorcontrib><creatorcontrib>Ianovsky, Oscar</creatorcontrib><creatorcontrib>Elizari, Marcelo V</creatorcontrib><creatorcontrib>Dini, Andrés</creatorcontrib><creatorcontrib>Pérez Lloret, Santiago</creatorcontrib><creatorcontrib>Albornoz, Liliana E</creatorcontrib><creatorcontrib>Cardinali, Daniel P</creatorcontrib><title>Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure</title><title>Endocrine</title><addtitle>Endocrine</addtitle><description>To assess urinary 6-sulfatoxymelatonin excretion in patients admitted to the hospital because of congestive heart failure (CHF).
Urinary 6-sulfatoxymelatonin was measured by a specific radioimmunoassay in 33 hospitalized patients with CHF and in 146 healthy ambulatory volunteers. Individuals with hepatic or renal failure were excluded from the sample. Data were analyzed by the Mann-Whitney test and regression analysis.
6-Sulfatoxymelatonin levels were significantly lower in CHF patients than controls (median 2.6 vs 6.02 microg, p < 0.0001). This decrease was observed regardless of beta-adrenergic blocker or benzodiazepine medication. A significant decrease in 6-sulfatoxymelatonin excretion occurred with age. There were no significant differences in urinary 6-sulfatoxymelatonin levels between chronic and acute CHF patients.
The results suggest that circulating melatonin levels are low in patients with CHF. Such a decrease may precede aggravation of heart failure.</description><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Benzodiazepines - therapeutic use</subject><subject>Female</subject><subject>Heart Failure - drug therapy</subject><subject>Heart Failure - metabolism</subject><subject>Heart Failure - urine</subject><subject>Humans</subject><subject>Male</subject><subject>Melatonin - analogs & derivatives</subject><subject>Melatonin - metabolism</subject><subject>Melatonin - urine</subject><subject>Middle Aged</subject><issn>1355-008X</issn><issn>0969-711X</issn><issn>0969-711X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtLAzEYxIMotlaPXiUnb6t5bF69idYHFHtR6C2k2ayNpLs12W3tf29KC57m4-PHMDMAXGN0h6lk95P3p9mYkDEdk5KdgCFSXBUC4_kpGGLKWIGQnA_ARUrfCBFCuDgHA1wKpIQSQzCftlvYR9-YuIO8SH2oTdf-7lYuZG18A4PbuJBgvtam867pEtz6bglT_kcHbdt8udT5jYNLZ2IHa-NDH90lOKtNSO7qqCPw-Tz5eHwtprOXt8eHaWGJVF0hlWEUS8kFtxRbyZjgKIdU1jLFKBGOs0pWJjfhGBlcGlLZquQVrlTNF4aOwO3Bdx3bnz4n0SufrAvBNK7tkxa4VFximcHiANrYphRdrdfRr3JtjZHeT6n3U2pCNNV5yszfHI37xcpV__RxO_oHvwxwAQ</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Girotti, Luis</creator><creator>Lago, Manuel</creator><creator>Ianovsky, Oscar</creator><creator>Elizari, Marcelo V</creator><creator>Dini, Andrés</creator><creator>Pérez Lloret, Santiago</creator><creator>Albornoz, Liliana E</creator><creator>Cardinali, Daniel P</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure</title><author>Girotti, Luis ; Lago, Manuel ; Ianovsky, Oscar ; Elizari, Marcelo V ; Dini, Andrés ; Pérez Lloret, Santiago ; Albornoz, Liliana E ; Cardinali, Daniel P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c289t-89a53188676c31c8557602679cc595327e65d8da355610a14a2dcd46d1d9f6ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adrenergic beta-Antagonists - therapeutic use</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Benzodiazepines - therapeutic use</topic><topic>Female</topic><topic>Heart Failure - drug therapy</topic><topic>Heart Failure - metabolism</topic><topic>Heart Failure - urine</topic><topic>Humans</topic><topic>Male</topic><topic>Melatonin - analogs & derivatives</topic><topic>Melatonin - metabolism</topic><topic>Melatonin - urine</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Girotti, Luis</creatorcontrib><creatorcontrib>Lago, Manuel</creatorcontrib><creatorcontrib>Ianovsky, Oscar</creatorcontrib><creatorcontrib>Elizari, Marcelo V</creatorcontrib><creatorcontrib>Dini, Andrés</creatorcontrib><creatorcontrib>Pérez Lloret, Santiago</creatorcontrib><creatorcontrib>Albornoz, Liliana E</creatorcontrib><creatorcontrib>Cardinali, Daniel P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Girotti, Luis</au><au>Lago, Manuel</au><au>Ianovsky, Oscar</au><au>Elizari, Marcelo V</au><au>Dini, Andrés</au><au>Pérez Lloret, Santiago</au><au>Albornoz, Liliana E</au><au>Cardinali, Daniel P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure</atitle><jtitle>Endocrine</jtitle><addtitle>Endocrine</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>22</volume><issue>3</issue><spage>245</spage><epage>248</epage><pages>245-248</pages><issn>1355-008X</issn><issn>0969-711X</issn><eissn>0969-711X</eissn><abstract>To assess urinary 6-sulfatoxymelatonin excretion in patients admitted to the hospital because of congestive heart failure (CHF).
Urinary 6-sulfatoxymelatonin was measured by a specific radioimmunoassay in 33 hospitalized patients with CHF and in 146 healthy ambulatory volunteers. Individuals with hepatic or renal failure were excluded from the sample. Data were analyzed by the Mann-Whitney test and regression analysis.
6-Sulfatoxymelatonin levels were significantly lower in CHF patients than controls (median 2.6 vs 6.02 microg, p < 0.0001). This decrease was observed regardless of beta-adrenergic blocker or benzodiazepine medication. A significant decrease in 6-sulfatoxymelatonin excretion occurred with age. There were no significant differences in urinary 6-sulfatoxymelatonin levels between chronic and acute CHF patients.
The results suggest that circulating melatonin levels are low in patients with CHF. Such a decrease may precede aggravation of heart failure.</abstract><cop>United States</cop><pmid>14709797</pmid><doi>10.1385/ENDO:22:3:245</doi><tpages>4</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adrenergic beta-Antagonists - therapeutic use Adult Age Factors Aged Aged, 80 and over Benzodiazepines - therapeutic use Female Heart Failure - drug therapy Heart Failure - metabolism Heart Failure - urine Humans Male Melatonin - analogs & derivatives Melatonin - metabolism Melatonin - urine Middle Aged |
| title | Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure |
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