How does recombinant human bone morphogenetic protein-4 enhance posterior spinal fusion?

A rabbit posterolateral intertransverse process fusion model was used to evaluate the effect that different doses of recombinant human bone morphogenetic protein-4 delivered in a porous hydroxyapatite-tricalcium phosphate ceramic had on osteogenesis and spinal fusion. To study the biologic effect an...

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Veröffentlicht in:	Spine (Philadelphia, Pa. 1976) Pa. 1976), 2002-03, Vol.27 (5), p.467-474
Hauptverfasser:	Cheng, Jack C Y, Guo, Xia, Law, Lai Pang, Lee, Kwong Man, Chow, Daniel H K, Rosier, Randy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins - administration & dosage Bone Morphogenetic Proteins - genetics Bone Substitutes - administration & dosage Calcium Phosphates - administration & dosage Ceramics Disease Models, Animal Dose-Response Relationship, Drug Drug Carriers - administration & dosage Humans Hydroxyapatites - administration & dosage Lumbar Vertebrae - drug effects Lumbar Vertebrae - surgery Osteogenesis - drug effects Prostheses and Implants Rabbits Recombinant Proteins - administration & dosage Recombinant Proteins - genetics Spinal Fusion - methods Time Factors Treatment Outcome
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