Effects of high inspired oxygen fraction during elective Caesarean section under spinal anaesthesia on maternal and fetal oxygenation and lipid peroxidation
Background. Oxygen supplementation is given routinely to parturients undergoing Caesarean section under regional anaesthesia. While the aim is to improve fetal oxygenation, inspiring a high oxygen fraction (FiO2) can also increase free radical activity and lipid peroxidation in both the mother and b...
Gespeichert in:
| Veröffentlicht in: | British journal of anaesthesia : BJA 2002-01, Vol.88 (1), p.18-23 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 23 |
|---|---|
| container_issue | 1 |
| container_start_page | 18 |
| container_title | British journal of anaesthesia : BJA |
| container_volume | 88 |
| creator | Khaw, K. S. Wang, C. C. Ngan Kee, W. D. Pang, C. P. Rogers, M. S. |
| description | Background. Oxygen supplementation is given routinely to parturients undergoing Caesarean section under regional anaesthesia. While the aim is to improve fetal oxygenation, inspiring a high oxygen fraction (FiO2) can also increase free radical activity and lipid peroxidation in both the mother and baby. In this prospective, randomized, double‐blind study, we investigated the effect of high inspired oxygen fraction (FiO2) on maternal and fetal oxygenation and oxygen free radical activity in parturients having Caesarean section under spinal anaesthesia.
Methods. Forty‐four healthy parturients were randomized to breathe either 21% (air group) or 60% oxygen (oxygen group) intraoperatively via a ventimask. Maternal arterial blood was collected at 5‐min intervals from baseline until delivery, and umbilical arterial and venous blood was collected at delivery. We measured blood gases and the products of lipid peroxidation (8‐isoprostane, malondialdehyde (MDA), hydroperoxide (OHP)) and purine metabolites.
Results. At delivery, the oxygen group had greater maternal arterial Po2 [mean 30.0 (sd 6.3) vs 14.2 (1.9) kPa; mean difference 15.8 kPa, 95% confidence interval 12.9–18.7 kPa, P |
| doi_str_mv | 10.1093/bja/88.1.18 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_71495663</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/bja/88.1.18</oup_id><sourcerecordid>98680055</sourcerecordid><originalsourceid>FETCH-LOGICAL-o295t-6ae398603a26d50be6eacc60c7d9a064ec46416fcb1503be3e3cb683faaf445a3</originalsourceid><addsrcrecordid>eNpdkU1v1DAQhi1ERZfCiTuykOCWrWedOM4RrQpUqtRLe7YmzmTXq6wd7AS1_4Ufi7e7aKWexnrfZ8bzwdgnEEsQjbxud3it9RKWoN-wBZQ1FKqu4S1bCCHqQjSwumTvU9oJAfWqqd6xSwCtpayrBft70_dkp8RDz7dus-XOp9FF6nh4et6Q531EO7ngeTdH5zechoy7P8TXSAkjoeeJjsTsO4o8p3scOPrsT1tKDnn29jhRPOod72nKr-MH-JJ6UAc3uo6PFMOT617kD-yixyHRx1O8Yo8_bh7Wv4q7-5-36-93RcjjTIVCko1WQuJKdZVoSRFaq4StuwaFKsmWqgTV2xYqIVuSJG2rtOwR-7KsUF6xb8e6Ywy_59y22btkaRjQU5iTqaFsKqVkBr-8AndhPoyVDDS1Flo3VYY-n6C53VNnxuj2GJ_N_6Vn4OsJwGRxyBv21qUzJytYlSDObYV5PLvCHK5u8tWN1gYMaPkPCj6gSg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>197808895</pqid></control><display><type>article</type><title>Effects of high inspired oxygen fraction during elective Caesarean section under spinal anaesthesia on maternal and fetal oxygenation and lipid peroxidation</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Khaw, K. S. ; Wang, C. C. ; Ngan Kee, W. D. ; Pang, C. P. ; Rogers, M. S.</creator><creatorcontrib>Khaw, K. S. ; Wang, C. C. ; Ngan Kee, W. D. ; Pang, C. P. ; Rogers, M. S.</creatorcontrib><description>Background. Oxygen supplementation is given routinely to parturients undergoing Caesarean section under regional anaesthesia. While the aim is to improve fetal oxygenation, inspiring a high oxygen fraction (FiO2) can also increase free radical activity and lipid peroxidation in both the mother and baby. In this prospective, randomized, double‐blind study, we investigated the effect of high inspired oxygen fraction (FiO2) on maternal and fetal oxygenation and oxygen free radical activity in parturients having Caesarean section under spinal anaesthesia.
Methods. Forty‐four healthy parturients were randomized to breathe either 21% (air group) or 60% oxygen (oxygen group) intraoperatively via a ventimask. Maternal arterial blood was collected at 5‐min intervals from baseline until delivery, and umbilical arterial and venous blood was collected at delivery. We measured blood gases and the products of lipid peroxidation (8‐isoprostane, malondialdehyde (MDA), hydroperoxide (OHP)) and purine metabolites.
Results. At delivery, the oxygen group had greater maternal arterial Po2 [mean 30.0 (sd 6.3) vs 14.2 (1.9) kPa; mean difference 15.8 kPa, 95% confidence interval 12.9–18.7 kPa, P<0.001] and greater umbilical venous Po2 [4.8 (1.0) vs 4.0 (1.4) kPa; mean difference 0.8 kPa, 95% confidence interval 0.0–1.5 kPa, P=0.04] compared with the air group. Maternal and umbilical plasma concentrations of lipid peroxides (8‐isoprostane, MDA, OHP) were greater in the oxygen group than in the air group (P<0.05).
Conclusions. We conclude that breathing high FiO2modestly increased fetal oxygenation but caused a concomitant increase in oxygen free radical activity in both mother and fetus.
Br J Anaesth 2002; 88: 18–23</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/88.1.18</identifier><identifier>PMID: 11883375</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Abdominal surgery. Urology. Gynecology. Obstetrics ; Adult ; Anesthesia ; Anesthesia depending on type of surgery ; Anesthesia, Obstetrical - methods ; Anesthesia, Spinal - methods ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Apgar Score ; Biological and medical sciences ; Carbon Dioxide - blood ; Cesarean Section ; Double-Blind Method ; Female ; Free Radicals - blood ; Humans ; Intraoperative Care - methods ; Lipid Peroxidation ; Maternal-Fetal Exchange ; Medical sciences ; Oxygen - blood ; Oxygen Consumption ; Oxygen Inhalation Therapy ; Partial Pressure ; Pregnancy ; Prospective Studies</subject><ispartof>British journal of anaesthesia : BJA, 2002-01, Vol.88 (1), p.18-23</ispartof><rights>2002</rights><rights>2002 INIST-CNRS</rights><rights>Copyright British Medical Association Jan 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13512410$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11883375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khaw, K. S.</creatorcontrib><creatorcontrib>Wang, C. C.</creatorcontrib><creatorcontrib>Ngan Kee, W. D.</creatorcontrib><creatorcontrib>Pang, C. P.</creatorcontrib><creatorcontrib>Rogers, M. S.</creatorcontrib><title>Effects of high inspired oxygen fraction during elective Caesarean section under spinal anaesthesia on maternal and fetal oxygenation and lipid peroxidation</title><title>British journal of anaesthesia : BJA</title><addtitle>Br. J. Anaesth</addtitle><addtitle>Br J Anaesth</addtitle><description>Background. Oxygen supplementation is given routinely to parturients undergoing Caesarean section under regional anaesthesia. While the aim is to improve fetal oxygenation, inspiring a high oxygen fraction (FiO2) can also increase free radical activity and lipid peroxidation in both the mother and baby. In this prospective, randomized, double‐blind study, we investigated the effect of high inspired oxygen fraction (FiO2) on maternal and fetal oxygenation and oxygen free radical activity in parturients having Caesarean section under spinal anaesthesia.
Methods. Forty‐four healthy parturients were randomized to breathe either 21% (air group) or 60% oxygen (oxygen group) intraoperatively via a ventimask. Maternal arterial blood was collected at 5‐min intervals from baseline until delivery, and umbilical arterial and venous blood was collected at delivery. We measured blood gases and the products of lipid peroxidation (8‐isoprostane, malondialdehyde (MDA), hydroperoxide (OHP)) and purine metabolites.
Results. At delivery, the oxygen group had greater maternal arterial Po2 [mean 30.0 (sd 6.3) vs 14.2 (1.9) kPa; mean difference 15.8 kPa, 95% confidence interval 12.9–18.7 kPa, P<0.001] and greater umbilical venous Po2 [4.8 (1.0) vs 4.0 (1.4) kPa; mean difference 0.8 kPa, 95% confidence interval 0.0–1.5 kPa, P=0.04] compared with the air group. Maternal and umbilical plasma concentrations of lipid peroxides (8‐isoprostane, MDA, OHP) were greater in the oxygen group than in the air group (P<0.05).
Conclusions. We conclude that breathing high FiO2modestly increased fetal oxygenation but caused a concomitant increase in oxygen free radical activity in both mother and fetus.
Br J Anaesth 2002; 88: 18–23</description><subject>Abdominal surgery. Urology. Gynecology. Obstetrics</subject><subject>Adult</subject><subject>Anesthesia</subject><subject>Anesthesia depending on type of surgery</subject><subject>Anesthesia, Obstetrical - methods</subject><subject>Anesthesia, Spinal - methods</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Apgar Score</subject><subject>Biological and medical sciences</subject><subject>Carbon Dioxide - blood</subject><subject>Cesarean Section</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Free Radicals - blood</subject><subject>Humans</subject><subject>Intraoperative Care - methods</subject><subject>Lipid Peroxidation</subject><subject>Maternal-Fetal Exchange</subject><subject>Medical sciences</subject><subject>Oxygen - blood</subject><subject>Oxygen Consumption</subject><subject>Oxygen Inhalation Therapy</subject><subject>Partial Pressure</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1v1DAQhi1ERZfCiTuykOCWrWedOM4RrQpUqtRLe7YmzmTXq6wd7AS1_4Ufi7e7aKWexnrfZ8bzwdgnEEsQjbxud3it9RKWoN-wBZQ1FKqu4S1bCCHqQjSwumTvU9oJAfWqqd6xSwCtpayrBft70_dkp8RDz7dus-XOp9FF6nh4et6Q531EO7ngeTdH5zechoy7P8TXSAkjoeeJjsTsO4o8p3scOPrsT1tKDnn29jhRPOod72nKr-MH-JJ6UAc3uo6PFMOT617kD-yixyHRx1O8Yo8_bh7Wv4q7-5-36-93RcjjTIVCko1WQuJKdZVoSRFaq4StuwaFKsmWqgTV2xYqIVuSJG2rtOwR-7KsUF6xb8e6Ywy_59y22btkaRjQU5iTqaFsKqVkBr-8AndhPoyVDDS1Flo3VYY-n6C53VNnxuj2GJ_N_6Vn4OsJwGRxyBv21qUzJytYlSDObYV5PLvCHK5u8tWN1gYMaPkPCj6gSg</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Khaw, K. S.</creator><creator>Wang, C. C.</creator><creator>Ngan Kee, W. D.</creator><creator>Pang, C. P.</creator><creator>Rogers, M. S.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>Effects of high inspired oxygen fraction during elective Caesarean section under spinal anaesthesia on maternal and fetal oxygenation and lipid peroxidation</title><author>Khaw, K. S. ; Wang, C. C. ; Ngan Kee, W. D. ; Pang, C. P. ; Rogers, M. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-o295t-6ae398603a26d50be6eacc60c7d9a064ec46416fcb1503be3e3cb683faaf445a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Abdominal surgery. Urology. Gynecology. Obstetrics</topic><topic>Adult</topic><topic>Anesthesia</topic><topic>Anesthesia depending on type of surgery</topic><topic>Anesthesia, Obstetrical - methods</topic><topic>Anesthesia, Spinal - methods</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Apgar Score</topic><topic>Biological and medical sciences</topic><topic>Carbon Dioxide - blood</topic><topic>Cesarean Section</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Free Radicals - blood</topic><topic>Humans</topic><topic>Intraoperative Care - methods</topic><topic>Lipid Peroxidation</topic><topic>Maternal-Fetal Exchange</topic><topic>Medical sciences</topic><topic>Oxygen - blood</topic><topic>Oxygen Consumption</topic><topic>Oxygen Inhalation Therapy</topic><topic>Partial Pressure</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khaw, K. S.</creatorcontrib><creatorcontrib>Wang, C. C.</creatorcontrib><creatorcontrib>Ngan Kee, W. D.</creatorcontrib><creatorcontrib>Pang, C. P.</creatorcontrib><creatorcontrib>Rogers, M. S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khaw, K. S.</au><au>Wang, C. C.</au><au>Ngan Kee, W. D.</au><au>Pang, C. P.</au><au>Rogers, M. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of high inspired oxygen fraction during elective Caesarean section under spinal anaesthesia on maternal and fetal oxygenation and lipid peroxidation</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><stitle>Br. J. Anaesth</stitle><addtitle>Br J Anaesth</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>88</volume><issue>1</issue><spage>18</spage><epage>23</epage><pages>18-23</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>Background. Oxygen supplementation is given routinely to parturients undergoing Caesarean section under regional anaesthesia. While the aim is to improve fetal oxygenation, inspiring a high oxygen fraction (FiO2) can also increase free radical activity and lipid peroxidation in both the mother and baby. In this prospective, randomized, double‐blind study, we investigated the effect of high inspired oxygen fraction (FiO2) on maternal and fetal oxygenation and oxygen free radical activity in parturients having Caesarean section under spinal anaesthesia.
Methods. Forty‐four healthy parturients were randomized to breathe either 21% (air group) or 60% oxygen (oxygen group) intraoperatively via a ventimask. Maternal arterial blood was collected at 5‐min intervals from baseline until delivery, and umbilical arterial and venous blood was collected at delivery. We measured blood gases and the products of lipid peroxidation (8‐isoprostane, malondialdehyde (MDA), hydroperoxide (OHP)) and purine metabolites.
Results. At delivery, the oxygen group had greater maternal arterial Po2 [mean 30.0 (sd 6.3) vs 14.2 (1.9) kPa; mean difference 15.8 kPa, 95% confidence interval 12.9–18.7 kPa, P<0.001] and greater umbilical venous Po2 [4.8 (1.0) vs 4.0 (1.4) kPa; mean difference 0.8 kPa, 95% confidence interval 0.0–1.5 kPa, P=0.04] compared with the air group. Maternal and umbilical plasma concentrations of lipid peroxides (8‐isoprostane, MDA, OHP) were greater in the oxygen group than in the air group (P<0.05).
Conclusions. We conclude that breathing high FiO2modestly increased fetal oxygenation but caused a concomitant increase in oxygen free radical activity in both mother and fetus.
Br J Anaesth 2002; 88: 18–23</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>11883375</pmid><doi>10.1093/bja/88.1.18</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0912 |
| ispartof | British journal of anaesthesia : BJA, 2002-01, Vol.88 (1), p.18-23 |
| issn | 0007-0912 1471-6771 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71495663 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Abdominal surgery. Urology. Gynecology. Obstetrics Adult Anesthesia Anesthesia depending on type of surgery Anesthesia, Obstetrical - methods Anesthesia, Spinal - methods Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Apgar Score Biological and medical sciences Carbon Dioxide - blood Cesarean Section Double-Blind Method Female Free Radicals - blood Humans Intraoperative Care - methods Lipid Peroxidation Maternal-Fetal Exchange Medical sciences Oxygen - blood Oxygen Consumption Oxygen Inhalation Therapy Partial Pressure Pregnancy Prospective Studies |
| title | Effects of high inspired oxygen fraction during elective Caesarean section under spinal anaesthesia on maternal and fetal oxygenation and lipid peroxidation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T23%3A57%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20high%20inspired%20oxygen%20fraction%20during%20elective%20Caesarean%20section%20under%20spinal%20anaesthesia%20on%20maternal%20and%20fetal%20oxygenation%20and%20lipid%20peroxidation&rft.jtitle=British%20journal%20of%20anaesthesia%20:%20BJA&rft.au=Khaw,%20K.%20S.&rft.date=2002-01-01&rft.volume=88&rft.issue=1&rft.spage=18&rft.epage=23&rft.pages=18-23&rft.issn=0007-0912&rft.eissn=1471-6771&rft.coden=BJANAD&rft_id=info:doi/10.1093/bja/88.1.18&rft_dat=%3Cproquest_pubme%3E98680055%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=197808895&rft_id=info:pmid/11883375&rft_oup_id=10.1093/bja/88.1.18&rfr_iscdi=true |