Constitutive EGFR signaling confers a motile phenotype to neural stem cells
The epidermal growth factor receptor (EGFR) has been shown to play an important role in brain development, including stem and precursor cell survival, proliferation, differentiation, and migration. To further examine the temporal and spatial requirements of erbB signals in uncommitted neural stem ce...
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| Veröffentlicht in: | Molecular and cellular neuroscience 2003-12, Vol.24 (4), p.1116-1130 |
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| container_title | Molecular and cellular neuroscience |
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| creator | Boockvar, John A Kapitonov, Dmitri Kapoor, Gurpreet Schouten, Joost Counelis, George J Bogler, Oliver Snyder, Evan Y McIntosh, Tracy K O'Rourke, Donald M |
| description | The epidermal growth factor receptor (EGFR) has been shown to play an important role in brain development, including stem and precursor cell survival, proliferation, differentiation, and migration. To further examine the temporal and spatial requirements of erbB signals in uncommitted neural stem cells (NSCs), we expressed the ligand-independent EGF receptor, EGFRvIII, in C17.2 NSCs. These NSCs are known to migrate and to evince a tropic response to neurodegenerative environments in vivo but for which an underlying mechanism remains unclear. We show that enhanced erbB signaling via constitutive kinase activity of EGFRvIII in NSCs sustains an immature phenotype and enhances NSC migration. |
| doi_str_mv | 10.1016/j.mcn.2003.09.011 |
| format | Article |
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| ispartof | Molecular and cellular neuroscience, 2003-12, Vol.24 (4), p.1116-1130 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cell Movement - physiology Genes, erbB-1 - physiology Male Neurons - metabolism Phenotype Rats Rats, Sprague-Dawley Receptor, Epidermal Growth Factor - biosynthesis Receptor, Epidermal Growth Factor - genetics Signal Transduction - physiology Stem Cells - metabolism |
| title | Constitutive EGFR signaling confers a motile phenotype to neural stem cells |
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