Hypophosphorylation of Poly(A) Polymerase and Increased Polyadenylation Activity Are Associated with Human Immunodeficiency Virus Type 1 Vpr Expression

The HIV-1 encoded accessory protein, viral protein R (Vpr) is responsible for several biological effects in HIV-1-infected cells including nuclear transport of the preintegration complex, activation of long terminal repeat (LTR)-mediated transcription, and the induction of cell-cycle arrest and apop...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2002-01, Vol.292 (2), p.321-330
Hauptverfasser:	Mouland, Andrew J., Coady, Michael, Yao, Xiao-Jian, Cohen, Éric A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line dephosphorylation Gene Expression Regulation, Viral Gene Products, vpr - genetics Gene Products, vpr - metabolism HIV Infections - virology HIV-1 HIV-1 - genetics HIV-1 - metabolism HIV-1 - pathogenicity Human immunodeficiency virus 1 Humans Jurkat Cells Phosphorylation Poly A - metabolism Poly(A) polymerase Polyadenylation Polynucleotide Adenylyltransferase - metabolism Vpr vpr Gene Products, Human Immunodeficiency Virus vpr protein
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