Differential regulation of matrix metalloproteinase activities in abdominal aortic aneurysms

The increased synthesis of matrix metalloproteinases (MMPs) by aortic smooth muscle cells (SMCs) is thought to be involved in the etiopathogenesis of abdominal aortic aneurysms (AAAs), but the functional regulation and the activation states of these MMPs remain unclear. In this study, we assessed th...

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Veröffentlicht in:	Journal of vascular surgery 2002-03, Vol.35 (3), p.539-546
Hauptverfasser:	Annabi, Borhane, Shédid, Daniel, Ghosn, Pierre, Kenigsberg, Rhoda L., Desrosiers, Richard R., Bojanowski, Michel W., Beaulieu, Edith, Nassif, Edgar, Moumdjian, Robert, Béliveau, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Aged Aged, 80 and over Aorta - enzymology Aortic Aneurysm, Abdominal - complications Aortic Aneurysm, Abdominal - enzymology Aortic Rupture - complications Aortic Rupture - enzymology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Collagenases - physiology Diseases of the aorta Enzyme Precursors - physiology Female Humans Macrophages - enzymology Male Matrix Metalloproteinase 1 Matrix Metalloproteinases - physiology Medical sciences Middle Aged Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - enzymology Protein Isoforms - metabolism
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