Sirolimus delays recovery of rat kidney transplants after ischemia-reperfusion injury

Sirolimus (SRL) seems to impair renal recovery from ischemic injury in animal models and delayed graft function after clinical renal transplantation. This study determined the impact of SRL on renal recovery after ischemia-reperfusion injury in a rat kidney transplant model. Syngeneic kidneys were p...

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Veröffentlicht in:	Transplantation 2003-12, Vol.76 (11), p.1594-1599
Hauptverfasser:	FULLER, T. Florian, FREISE, Chris E, SERKOVA, Natalie, NIEMANN, Claus U, OLSON, Jean L, FENG, Sandy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Allopurinol Animals Biological and medical sciences Combined surgery. Multiple transplantations Creatinine - blood Glutathione Immunosuppressive Agents - pharmacokinetics Immunosuppressive Agents - therapeutic use Insulin Kidney Kidney Transplantation - immunology Kidney Transplantation - pathology Kidney Transplantation - physiology Medical sciences Organ Preservation Solutions Raffinose Rats Reperfusion Injury - complications Sirolimus - pharmacokinetics Sirolimus - therapeutic use Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Time Factors Transplantation, Isogeneic Treatment Outcome
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