Effect of sirolimus on the cholesterol content of aortic arch in ApoE knockout mice
Chronic inflammatory responses involving the immune system have been implicated in the process of atherosclerosis. Sirolimus (Rapamycin, Rapamune®), a potent immunosuppressant used to prevent rejection of transplanted kidneys, has also proven effective at inhibiting restenosis in humans when eluted...
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| Veröffentlicht in: | Transplantation proceedings 2003-12, Vol.35 (8), p.3136-3138 |
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| container_title | Transplantation proceedings |
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| creator | Basso, M.D Nambi, P Adelman, S.J |
| description | Chronic inflammatory responses involving the immune system have been implicated in the process of atherosclerosis. Sirolimus (Rapamycin, Rapamune®), a potent immunosuppressant used to prevent rejection of transplanted kidneys, has also proven effective at inhibiting restenosis in humans when eluted from implanted stents. The aim of this study was to evaluate the effect of sirolimus treatment on the development of atherosclerosis in the aortic arch of apo E
−/− mice fed a high-fat (Western) diet. Following 12 weeks of treatment with sirolimus (4 mg/kg/d), the cholesterol content of the arch was reduced by 36% compared to untreated control mice fed the Western diet only. Although the murine model is not comparable to the human situation, the results of this study suggest that sirolimus may exert beneficial effects on atherosclerosis in transplant patients. |
| doi_str_mv | 10.1016/j.transproceed.2003.10.050 |
| format | Article |
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−/− mice fed a high-fat (Western) diet. Following 12 weeks of treatment with sirolimus (4 mg/kg/d), the cholesterol content of the arch was reduced by 36% compared to untreated control mice fed the Western diet only. Although the murine model is not comparable to the human situation, the results of this study suggest that sirolimus may exert beneficial effects on atherosclerosis in transplant patients.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2003.10.050</identifier><identifier>PMID: 14697997</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Aorta, Thoracic - drug effects ; Aorta, Thoracic - metabolism ; Apolipoproteins E - deficiency ; Apolipoproteins E - genetics ; Biological and medical sciences ; Cholesterol - blood ; Drug toxicity and drugs side effects treatment ; Graft Occlusion, Vascular - prevention & control ; Humans ; Immunomodulators ; Immunosuppressive Agents - pharmacology ; Medical sciences ; Mice ; Mice, Knockout ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Models, Animal ; Pharmacology. Drug treatments ; Sirolimus - pharmacology</subject><ispartof>Transplantation proceedings, 2003-12, Vol.35 (8), p.3136-3138</ispartof><rights>2003 Elsevier Science Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-fb2ae279582ae90ff62b0eba71ea0778f1ac60d32c964c454829f838836667243</citedby><cites>FETCH-LOGICAL-c406t-fb2ae279582ae90ff62b0eba71ea0778f1ac60d32c964c454829f838836667243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2003.10.050$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15399211$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14697997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Basso, M.D</creatorcontrib><creatorcontrib>Nambi, P</creatorcontrib><creatorcontrib>Adelman, S.J</creatorcontrib><title>Effect of sirolimus on the cholesterol content of aortic arch in ApoE knockout mice</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Chronic inflammatory responses involving the immune system have been implicated in the process of atherosclerosis. Sirolimus (Rapamycin, Rapamune®), a potent immunosuppressant used to prevent rejection of transplanted kidneys, has also proven effective at inhibiting restenosis in humans when eluted from implanted stents. The aim of this study was to evaluate the effect of sirolimus treatment on the development of atherosclerosis in the aortic arch of apo E
−/− mice fed a high-fat (Western) diet. Following 12 weeks of treatment with sirolimus (4 mg/kg/d), the cholesterol content of the arch was reduced by 36% compared to untreated control mice fed the Western diet only. Although the murine model is not comparable to the human situation, the results of this study suggest that sirolimus may exert beneficial effects on atherosclerosis in transplant patients.</description><subject>Animals</subject><subject>Aorta, Thoracic - drug effects</subject><subject>Aorta, Thoracic - metabolism</subject><subject>Apolipoproteins E - deficiency</subject><subject>Apolipoproteins E - genetics</subject><subject>Biological and medical sciences</subject><subject>Cholesterol - blood</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Graft Occlusion, Vascular - prevention & control</subject><subject>Humans</subject><subject>Immunomodulators</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Models, Animal</subject><subject>Pharmacology. Drug treatments</subject><subject>Sirolimus - pharmacology</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtvEzEQgC1UREPhL1QWUrlt8GvtdW9VCQ-pEgfas-VMxorT3XVq71bi3-OQqHDkNLLnm4c_E_KBsyVnXH_aLafsx7LPCRA3S8GYrIkla9krsuCdkY3QQp6RBWOKN1yq9py8LWXH6lko-Yacc6WtsdYsyM9VCAgTTYGWmFMfh7nQNNJpixS2qccyYb2mkMYJxz-cT3mKQH2GLY0jvdmnFX0cEzymeaJDBHxHXgffF3x_ihfk4cvq_vZbc_fj6_fbm7sGFNNTE9bCozC27Wq0LAQt1gzX3nD0zJgucA-abaQAqxWoVnXChk52ndRam_qQC_Lx2LeaeJrrpm6IBbDv_YhpLs5wZUWrbAWvjyDkVErG4PY5Dj7_cpy5g1K3c_8qdQelh1xVWosvT1Pm9VBzL6UnhxW4OgG-gO9DbQSx_OVaaa3gvHKfjxxWJ88RsysQcQTcxFy_wG1S_J99fgPnVZtc</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Basso, M.D</creator><creator>Nambi, P</creator><creator>Adelman, S.J</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>Effect of sirolimus on the cholesterol content of aortic arch in ApoE knockout mice</title><author>Basso, M.D ; Nambi, P ; Adelman, S.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-fb2ae279582ae90ff62b0eba71ea0778f1ac60d32c964c454829f838836667243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Aorta, Thoracic - drug effects</topic><topic>Aorta, Thoracic - metabolism</topic><topic>Apolipoproteins E - deficiency</topic><topic>Apolipoproteins E - genetics</topic><topic>Biological and medical sciences</topic><topic>Cholesterol - blood</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Graft Occlusion, Vascular - prevention & control</topic><topic>Humans</topic><topic>Immunomodulators</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Models, Animal</topic><topic>Pharmacology. Drug treatments</topic><topic>Sirolimus - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Basso, M.D</creatorcontrib><creatorcontrib>Nambi, P</creatorcontrib><creatorcontrib>Adelman, S.J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Basso, M.D</au><au>Nambi, P</au><au>Adelman, S.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of sirolimus on the cholesterol content of aortic arch in ApoE knockout mice</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>35</volume><issue>8</issue><spage>3136</spage><epage>3138</epage><pages>3136-3138</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Chronic inflammatory responses involving the immune system have been implicated in the process of atherosclerosis. 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−/− mice fed a high-fat (Western) diet. Following 12 weeks of treatment with sirolimus (4 mg/kg/d), the cholesterol content of the arch was reduced by 36% compared to untreated control mice fed the Western diet only. Although the murine model is not comparable to the human situation, the results of this study suggest that sirolimus may exert beneficial effects on atherosclerosis in transplant patients.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>14697997</pmid><doi>10.1016/j.transproceed.2003.10.050</doi><tpages>3</tpages></addata></record> |
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| ispartof | Transplantation proceedings, 2003-12, Vol.35 (8), p.3136-3138 |
| issn | 0041-1345 1873-2623 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Apolipoproteins E - deficiency Apolipoproteins E - genetics Biological and medical sciences Cholesterol - blood Drug toxicity and drugs side effects treatment Graft Occlusion, Vascular - prevention & control Humans Immunomodulators Immunosuppressive Agents - pharmacology Medical sciences Mice Mice, Knockout Miscellaneous (drug allergy, mutagens, teratogens...) Models, Animal Pharmacology. Drug treatments Sirolimus - pharmacology |
| title | Effect of sirolimus on the cholesterol content of aortic arch in ApoE knockout mice |
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