Replicative enzymes, DNA polymerase alpha (pol α), and in vitro ageing

Normal cells in culture are used to investigate the underlying mechanisms of DNA synthesis because they retain regulatory characteristics of the in vivo replication machinery. During the last few years new studies have identified a number of genetic changes that occur during in vitro ageing, providi...

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Veröffentlicht in:	Experimental gerontology 2003-11, Vol.38 (11), p.1285-1297
Hauptverfasser:	Srivastava, Vinod K., Busbee, David L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Accessory protein Cell cycle Cell Cycle - genetics Cell Division - physiology Cellular Senescence - genetics DNA Polymerase I - physiology DNA polymerase α DNA Replication - physiology Humans In vitro ageing Protein Kinases - physiology Senescence
Online-Zugang:	Volltext
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