Oral Flavonoids, Chromocarb Diethylamine Salt and Cyaninosides Chloride, to Eliminate Lipoperoxidation Postvitrectomy
This study was undertaken to determine the concentration of malondialdehyde, an end product of lipoperoxidation, in lens and retinal tissue postvitrectomy associated with oral administration of antioxidant flavonoids cyaninosides chloride and chromocarb diethylamine salt or N -acetylcysteine. Fifty...
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| Veröffentlicht in: | Experimental eye research 2002-01, Vol.74 (1), p.23-28 |
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| creator | Manzanas, Lucia Jesús del Nozal, MarIA Marcos, Manuel Ángel Cordero, Yolanda Bernal, José Luis Goldschmidt, Pablo Pastor, José Carlos |
| description | This study was undertaken to determine the concentration of malondialdehyde, an end product of lipoperoxidation, in lens and retinal tissue postvitrectomy associated with oral administration of antioxidant flavonoids cyaninosides chloride and chromocarb diethylamine salt or N -acetylcysteine. Fifty adult pigmented rabbits were divided into five groups: (1) controls (normal eyes, malondialdehyde concentration in lens and retina); (2) vitrectomy with BSS Plus®(malondialdehyde level measured 2hr after vitrectomy); (3) vitrectomy with BSS Plus®and pretreatment with oral cyaninosides chloride 100mgkgday−1for 3 weeks (malondialdehyde level measured 2hr after surgery); (4) vitrectomy with BSS Plus®and pretreatment with oral chromocarb diethylamine salt 100mgkgday−1for 3 weeks (malondialdehyde level measured 2hr after surgery); and (5) vitrectomy with BSS Plus®and pretreatment with oral N -acetylcysteine 200mgkgday−1for 3 weeks (malondialdehyde level measured 2hr after surgery). Lens and retina samples were used to determine malondialdehyde levels using ion-pairing high performance liquid chromatography. Statistical analysis was done using analysis of variance (P |
| doi_str_mv | 10.1006/exer.2001.1069 |
| format | Article |
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Fifty adult pigmented rabbits were divided into five groups: (1) controls (normal eyes, malondialdehyde concentration in lens and retina); (2) vitrectomy with BSS Plus®(malondialdehyde level measured 2hr after vitrectomy); (3) vitrectomy with BSS Plus®and pretreatment with oral cyaninosides chloride 100mgkgday−1for 3 weeks (malondialdehyde level measured 2hr after surgery); (4) vitrectomy with BSS Plus®and pretreatment with oral chromocarb diethylamine salt 100mgkgday−1for 3 weeks (malondialdehyde level measured 2hr after surgery); and (5) vitrectomy with BSS Plus®and pretreatment with oral N -acetylcysteine 200mgkgday−1for 3 weeks (malondialdehyde level measured 2hr after surgery). Lens and retina samples were used to determine malondialdehyde levels using ion-pairing high performance liquid chromatography. Statistical analysis was done using analysis of variance (P<0.05). The content of malondialdehyde in the normal lens was 0.036±0.017μ gg−1; in the vitrectomized groups the malondialdehyde concentrations were as follows: (2) 0.027±0.013μ gg−1; (3) under detection limit (detection limit=1.75×e-3μ gg−1); (4) under detection limit; and (5) 0.020±0.006μ gg−1. The results showed that the malondialdehyde concentration in the normal retina was 1.160±0.361μ gg−1, while in the vitrectomized groups with or without pretreatment (cyaninosides chloride, chromocarb diethylamine salt, and N -acetylcysteine) the malondialdehyde levels were 2.091±0.982μ gg−1, 0.069±0.024μ gg−1, 0.082±0.027μ gg−1, and 0.215±0.134μ g/g−1, respectively, all significantly different from the normal eyes (P<0.05). Vitrectomy induced increased malondialdehyde levels in the retina. Oral flavonoids are an effective protective therapy for surgically induced lipoperoxidation, especially in the retina.</description><identifier>ISSN: 0014-4835</identifier><identifier>EISSN: 1096-0007</identifier><identifier>DOI: 10.1006/exer.2001.1069</identifier><identifier>PMID: 11878815</identifier><identifier>CODEN: EXERA6</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Administration, Oral ; Animals ; Anthocyanins ; Antioxidants - pharmacology ; Biological and medical sciences ; chromocarb diethylamine salt ; Chromones - pharmacology ; cyaninosides chloride ; Diethylamines - pharmacology ; Drug Combinations ; flavonoids ; Flavonoids - pharmacology ; Lens, Crystalline - chemistry ; Lipid Peroxidation - drug effects ; lipids ; malondialdehyde ; Malondialdehyde - analysis ; Medical sciences ; Miscellaneous ; N -acetylcysteine ; Ophthalmology ; Postoperative Period ; Rabbits ; Retina - chemistry ; vitrectomy ; Vitrectomy - adverse effects</subject><ispartof>Experimental eye research, 2002-01, Vol.74 (1), p.23-28</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 Elsevier Science Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-198395048d3b0c9e04276cef053945f150bcea53942177205a5329d4f60097c73</citedby><cites>FETCH-LOGICAL-c436t-198395048d3b0c9e04276cef053945f150bcea53942177205a5329d4f60097c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014483501910693$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13628364$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11878815$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manzanas, Lucia</creatorcontrib><creatorcontrib>Jesús del Nozal, MarIA</creatorcontrib><creatorcontrib>Marcos, Manuel Ángel</creatorcontrib><creatorcontrib>Cordero, Yolanda</creatorcontrib><creatorcontrib>Bernal, José Luis</creatorcontrib><creatorcontrib>Goldschmidt, Pablo</creatorcontrib><creatorcontrib>Pastor, José Carlos</creatorcontrib><title>Oral Flavonoids, Chromocarb Diethylamine Salt and Cyaninosides Chloride, to Eliminate Lipoperoxidation Postvitrectomy</title><title>Experimental eye research</title><addtitle>Exp Eye Res</addtitle><description>This study was undertaken to determine the concentration of malondialdehyde, an end product of lipoperoxidation, in lens and retinal tissue postvitrectomy associated with oral administration of antioxidant flavonoids cyaninosides chloride and chromocarb diethylamine salt or N -acetylcysteine. Fifty adult pigmented rabbits were divided into five groups: (1) controls (normal eyes, malondialdehyde concentration in lens and retina); (2) vitrectomy with BSS Plus®(malondialdehyde level measured 2hr after vitrectomy); (3) vitrectomy with BSS Plus®and pretreatment with oral cyaninosides chloride 100mgkgday−1for 3 weeks (malondialdehyde level measured 2hr after surgery); (4) vitrectomy with BSS Plus®and pretreatment with oral chromocarb diethylamine salt 100mgkgday−1for 3 weeks (malondialdehyde level measured 2hr after surgery); and (5) vitrectomy with BSS Plus®and pretreatment with oral N -acetylcysteine 200mgkgday−1for 3 weeks (malondialdehyde level measured 2hr after surgery). Lens and retina samples were used to determine malondialdehyde levels using ion-pairing high performance liquid chromatography. Statistical analysis was done using analysis of variance (P<0.05). The content of malondialdehyde in the normal lens was 0.036±0.017μ gg−1; in the vitrectomized groups the malondialdehyde concentrations were as follows: (2) 0.027±0.013μ gg−1; (3) under detection limit (detection limit=1.75×e-3μ gg−1); (4) under detection limit; and (5) 0.020±0.006μ gg−1. The results showed that the malondialdehyde concentration in the normal retina was 1.160±0.361μ gg−1, while in the vitrectomized groups with or without pretreatment (cyaninosides chloride, chromocarb diethylamine salt, and N -acetylcysteine) the malondialdehyde levels were 2.091±0.982μ gg−1, 0.069±0.024μ gg−1, 0.082±0.027μ gg−1, and 0.215±0.134μ g/g−1, respectively, all significantly different from the normal eyes (P<0.05). Vitrectomy induced increased malondialdehyde levels in the retina. Oral flavonoids are an effective protective therapy for surgically induced lipoperoxidation, especially in the retina.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Anthocyanins</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>chromocarb diethylamine salt</subject><subject>Chromones - pharmacology</subject><subject>cyaninosides chloride</subject><subject>Diethylamines - pharmacology</subject><subject>Drug Combinations</subject><subject>flavonoids</subject><subject>Flavonoids - pharmacology</subject><subject>Lens, Crystalline - chemistry</subject><subject>Lipid Peroxidation - drug effects</subject><subject>lipids</subject><subject>malondialdehyde</subject><subject>Malondialdehyde - analysis</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>N -acetylcysteine</subject><subject>Ophthalmology</subject><subject>Postoperative Period</subject><subject>Rabbits</subject><subject>Retina - chemistry</subject><subject>vitrectomy</subject><subject>Vitrectomy - adverse effects</subject><issn>0014-4835</issn><issn>1096-0007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM2LEzEUwIMobl29epRc9LRTXyaZycxRursqFFZQzyFN3rCRTFKTtGz_ezO0sCdP74Pf--BHyHsGawbQf8YnTOsWgNWyH1-QFYOxbwBAviSr2haNGHh3Rd7k_Kd2uZDiNblibJDDwLoVOTwk7em918cYorP5hm4eU5yj0WlHbx2Wx5PXswtIf2pfqA6Wbk46uBCzs5gr7WOq2Q0tkd55V1FdkG7dPu4xxSdndXEx0B8xl6MrCU2J8-kteTVpn_HdJV6T3_d3vzbfmu3D1--bL9vGCN6Xho0DHzsQg-U7MCOCaGVvcIKOj6KbWAc7g3opWiZlC13N29GKqQcYpZH8mnw6792n-PeAuajZZYPe64DxkJVkYmRcdBVcn0GTYs4JJ7VPbtbppBioRbRaRKtFtFpE14EPl82H3Yz2Gb-YrcDHC6Cz0X5KOhiXnznetwPvReWGM4fVw9HVI9k4DAatW2QpG93_fvgH7VqaQA</recordid><startdate>200201</startdate><enddate>200201</enddate><creator>Manzanas, Lucia</creator><creator>Jesús del Nozal, MarIA</creator><creator>Marcos, Manuel Ángel</creator><creator>Cordero, Yolanda</creator><creator>Bernal, José Luis</creator><creator>Goldschmidt, Pablo</creator><creator>Pastor, José Carlos</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200201</creationdate><title>Oral Flavonoids, Chromocarb Diethylamine Salt and Cyaninosides Chloride, to Eliminate Lipoperoxidation Postvitrectomy</title><author>Manzanas, Lucia ; Jesús del Nozal, MarIA ; Marcos, Manuel Ángel ; Cordero, Yolanda ; Bernal, José Luis ; Goldschmidt, Pablo ; Pastor, José Carlos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-198395048d3b0c9e04276cef053945f150bcea53942177205a5329d4f60097c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Anthocyanins</topic><topic>Antioxidants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>chromocarb diethylamine salt</topic><topic>Chromones - pharmacology</topic><topic>cyaninosides chloride</topic><topic>Diethylamines - pharmacology</topic><topic>Drug Combinations</topic><topic>flavonoids</topic><topic>Flavonoids - pharmacology</topic><topic>Lens, Crystalline - chemistry</topic><topic>Lipid Peroxidation - drug effects</topic><topic>lipids</topic><topic>malondialdehyde</topic><topic>Malondialdehyde - analysis</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>N -acetylcysteine</topic><topic>Ophthalmology</topic><topic>Postoperative Period</topic><topic>Rabbits</topic><topic>Retina - chemistry</topic><topic>vitrectomy</topic><topic>Vitrectomy - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manzanas, Lucia</creatorcontrib><creatorcontrib>Jesús del Nozal, MarIA</creatorcontrib><creatorcontrib>Marcos, Manuel Ángel</creatorcontrib><creatorcontrib>Cordero, Yolanda</creatorcontrib><creatorcontrib>Bernal, José Luis</creatorcontrib><creatorcontrib>Goldschmidt, Pablo</creatorcontrib><creatorcontrib>Pastor, José Carlos</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental eye research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manzanas, Lucia</au><au>Jesús del Nozal, MarIA</au><au>Marcos, Manuel Ángel</au><au>Cordero, Yolanda</au><au>Bernal, José Luis</au><au>Goldschmidt, Pablo</au><au>Pastor, José Carlos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral Flavonoids, Chromocarb Diethylamine Salt and Cyaninosides Chloride, to Eliminate Lipoperoxidation Postvitrectomy</atitle><jtitle>Experimental eye research</jtitle><addtitle>Exp Eye Res</addtitle><date>2002-01</date><risdate>2002</risdate><volume>74</volume><issue>1</issue><spage>23</spage><epage>28</epage><pages>23-28</pages><issn>0014-4835</issn><eissn>1096-0007</eissn><coden>EXERA6</coden><abstract>This study was undertaken to determine the concentration of malondialdehyde, an end product of lipoperoxidation, in lens and retinal tissue postvitrectomy associated with oral administration of antioxidant flavonoids cyaninosides chloride and chromocarb diethylamine salt or N -acetylcysteine. Fifty adult pigmented rabbits were divided into five groups: (1) controls (normal eyes, malondialdehyde concentration in lens and retina); (2) vitrectomy with BSS Plus®(malondialdehyde level measured 2hr after vitrectomy); (3) vitrectomy with BSS Plus®and pretreatment with oral cyaninosides chloride 100mgkgday−1for 3 weeks (malondialdehyde level measured 2hr after surgery); (4) vitrectomy with BSS Plus®and pretreatment with oral chromocarb diethylamine salt 100mgkgday−1for 3 weeks (malondialdehyde level measured 2hr after surgery); and (5) vitrectomy with BSS Plus®and pretreatment with oral N -acetylcysteine 200mgkgday−1for 3 weeks (malondialdehyde level measured 2hr after surgery). Lens and retina samples were used to determine malondialdehyde levels using ion-pairing high performance liquid chromatography. Statistical analysis was done using analysis of variance (P<0.05). The content of malondialdehyde in the normal lens was 0.036±0.017μ gg−1; in the vitrectomized groups the malondialdehyde concentrations were as follows: (2) 0.027±0.013μ gg−1; (3) under detection limit (detection limit=1.75×e-3μ gg−1); (4) under detection limit; and (5) 0.020±0.006μ gg−1. The results showed that the malondialdehyde concentration in the normal retina was 1.160±0.361μ gg−1, while in the vitrectomized groups with or without pretreatment (cyaninosides chloride, chromocarb diethylamine salt, and N -acetylcysteine) the malondialdehyde levels were 2.091±0.982μ gg−1, 0.069±0.024μ gg−1, 0.082±0.027μ gg−1, and 0.215±0.134μ g/g−1, respectively, all significantly different from the normal eyes (P<0.05). Vitrectomy induced increased malondialdehyde levels in the retina. Oral flavonoids are an effective protective therapy for surgically induced lipoperoxidation, especially in the retina.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>11878815</pmid><doi>10.1006/exer.2001.1069</doi><tpages>6</tpages></addata></record> |
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| subjects | Administration, Oral Animals Anthocyanins Antioxidants - pharmacology Biological and medical sciences chromocarb diethylamine salt Chromones - pharmacology cyaninosides chloride Diethylamines - pharmacology Drug Combinations flavonoids Flavonoids - pharmacology Lens, Crystalline - chemistry Lipid Peroxidation - drug effects lipids malondialdehyde Malondialdehyde - analysis Medical sciences Miscellaneous N -acetylcysteine Ophthalmology Postoperative Period Rabbits Retina - chemistry vitrectomy Vitrectomy - adverse effects |
| title | Oral Flavonoids, Chromocarb Diethylamine Salt and Cyaninosides Chloride, to Eliminate Lipoperoxidation Postvitrectomy |
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