Oral Flavonoids, Chromocarb Diethylamine Salt and Cyaninosides Chloride, to Eliminate Lipoperoxidation Postvitrectomy

This study was undertaken to determine the concentration of malondialdehyde, an end product of lipoperoxidation, in lens and retinal tissue postvitrectomy associated with oral administration of antioxidant flavonoids cyaninosides chloride and chromocarb diethylamine salt or N -acetylcysteine. Fifty adult pigmented rabbits were divided into five groups: (1) controls (normal eyes, malondialdehyde concentration in lens and retina); (2) vitrectomy with BSS Plus®(malondialdehyde level measured 2hr after vitrectomy); (3) vitrectomy with BSS Plus®and pretreatment with oral cyaninosides chloride 100mgkgday−1for 3 weeks (malondialdehyde level measured 2hr after surgery); (4) vitrectomy with BSS Plus®and pretreatment with oral chromocarb diethylamine salt 100mgkgday−1for 3 weeks (malondialdehyde level measured 2hr after surgery); and (5) vitrectomy with BSS Plus®and pretreatment with oral N -acetylcysteine 200mgkgday−1for 3 weeks (malondialdehyde level measured 2hr after surgery). Lens and retina samples were used to determine malondialdehyde levels using ion-pairing high performance liquid chromatography. Statistical analysis was done using analysis of variance (P