Adenosine A(3) receptor-mediated potentiation of mucociliary transport and epithelial ciliary motility

To examine the effect of adenosine A(3) receptor stimulation on airway mucociliary clearance, we measured transport of Evans blue dye in rabbit trachea in vivo and ciliary motility of epithelium by the photoelectric method in vitro. Mucociliary transport was enhanced dose dependently by the selectiv...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2002-03, Vol.282 (3), p.L556-L562
Hauptverfasser:	Taira, Manako, Tamaoki, Jun, Nishimura, Kazuyuki, Nakata, Junko, Kondo, Mitsuko, Takemura, Hisashi, Nagai, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Animals Calcium - metabolism Cilia - drug effects Cilia - physiology Dose-Response Relationship, Drug Epithelium - physiology Intracellular Membranes - metabolism Mucociliary Clearance - drug effects Mucociliary Clearance - physiology Osmolar Concentration Purinergic P1 Receptor Agonists Rabbits Receptor, Adenosine A3 Receptors, Purinergic P1 - physiology Respiratory Mucosa - physiology Trachea - physiology
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