Screening approach for chiral separation of pharmaceuticals: Part I. Normal-phase liquid chromatography
A strategy for rapid screening for the separation of chiral molecules of pharmaceutical interest by normal-phase liquid chromatography using three cellulose/amylose stationary phases is proposed. In a first step, the most important parameters for the separations were determined and studied for their...
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| Veröffentlicht in: | Journal of Chromatography A 2002-02, Vol.947 (1), p.69-83 |
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| container_end_page | 83 |
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| container_title | Journal of Chromatography A |
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| creator | Perrin, C Vu, V.A Matthijs, N Maftouh, M Massart, D.L Vander Heyden, Y |
| description | A strategy for rapid screening for the separation of chiral molecules of pharmaceutical interest by normal-phase liquid chromatography using three cellulose/amylose stationary phases is proposed. In a first step, the most important parameters for the separations were determined and studied for their effects by means of experimental designs. Results showed that the cellulose tris-(3,5-dimethylphenylcarbamate), the amylose tris-(3,5-dimethylphenylcarbamate) and the cellulose tris-(4-methylbenzoate) stationary phases have very broad and complementary enantiorecognition properties. The type of organic modifier used in the mobile phase appeared to have a dramatic influence on the quality of the separation. Based on the results of the preliminary study, a screening strategy was developed and successfully applied to a set of 36 diverse drugs. Enantiomeric separation was observed in 89% of cases and the analysis times were usually shorter than 20 min. |
| doi_str_mv | 10.1016/S0021-9673(01)01573-4 |
| format | Article |
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The type of organic modifier used in the mobile phase appeared to have a dramatic influence on the quality of the separation. Based on the results of the preliminary study, a screening strategy was developed and successfully applied to a set of 36 diverse drugs. Enantiomeric separation was observed in 89% of cases and the analysis times were usually shorter than 20 min.</description><identifier>ISSN: 0021-9673</identifier><identifier>DOI: 10.1016/S0021-9673(01)01573-4</identifier><identifier>PMID: 11873999</identifier><identifier>CODEN: JOCRAM</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Biological and medical sciences ; Chromatography, Liquid - methods ; General pharmacology ; Medical sciences ; Pharmaceutical Preparations - chemistry ; Pharmaceutical Preparations - isolation & purification ; Pharmaceuticals ; Pharmacology. 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Normal-phase liquid chromatography</title><title>Journal of Chromatography A</title><addtitle>J Chromatogr A</addtitle><description>A strategy for rapid screening for the separation of chiral molecules of pharmaceutical interest by normal-phase liquid chromatography using three cellulose/amylose stationary phases is proposed. In a first step, the most important parameters for the separations were determined and studied for their effects by means of experimental designs. Results showed that the cellulose tris-(3,5-dimethylphenylcarbamate), the amylose tris-(3,5-dimethylphenylcarbamate) and the cellulose tris-(4-methylbenzoate) stationary phases have very broad and complementary enantiorecognition properties. The type of organic modifier used in the mobile phase appeared to have a dramatic influence on the quality of the separation. Based on the results of the preliminary study, a screening strategy was developed and successfully applied to a set of 36 diverse drugs. Enantiomeric separation was observed in 89% of cases and the analysis times were usually shorter than 20 min.</description><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Liquid - methods</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Pharmaceutical Preparations - isolation & purification</subject><subject>Pharmaceuticals</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Stereoisomerism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perrin, C</creatorcontrib><creatorcontrib>Vu, V.A</creatorcontrib><creatorcontrib>Matthijs, N</creatorcontrib><creatorcontrib>Maftouh, M</creatorcontrib><creatorcontrib>Massart, D.L</creatorcontrib><creatorcontrib>Vander Heyden, Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perrin, C</au><au>Vu, V.A</au><au>Matthijs, N</au><au>Maftouh, M</au><au>Massart, D.L</au><au>Vander Heyden, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Screening approach for chiral separation of pharmaceuticals: Part I. 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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Analysis Biological and medical sciences Chromatography, Liquid - methods General pharmacology Medical sciences Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - isolation & purification Pharmaceuticals Pharmacology. Drug treatments Stereoisomerism |
| title | Screening approach for chiral separation of pharmaceuticals: Part I. Normal-phase liquid chromatography |
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