Polymorphisms in the estrogen receptor-alpha gene and breast cancer risk
The estrogen receptor-alpha (ERα) has been known to play a role in the development and progression of breast cancer. Several genetic polymorphisms in the ERα gene have been related to breast cancer risk and/or different tumor characteristics. In this study, PCR and direct sequencing based methods we...
Gespeichert in:
| Veröffentlicht in: | Cancer letters 2002-04, Vol.178 (2), p.175-180 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 180 |
|---|---|
| container_issue | 2 |
| container_start_page | 175 |
| container_title | Cancer letters |
| container_volume | 178 |
| creator | Kang, Hee-Joon Kim, Sung-Won Kim, Hee Joung Ahn, Soo-Jung Bae, Ji-Yeon Park, Sue Kyung Kang, Daehee Hirvonen, Ari Choe, Kuk Jin Noh, Dong-Young |
| description | The estrogen receptor-alpha (ERα) has been known to play a role in the development and progression of breast cancer. Several genetic polymorphisms in the
ERα gene have been related to breast cancer risk and/or different tumor characteristics. In this study, PCR and direct sequencing based methods were used to examine this issue further in a Korean study population consisting of 155 women, 110 with breast cancer and 45 without cancer. We also assessed the potential role of the
ERα genotype in ER, PR, p53, c-erbB2, and bcl-2 expression. Only one of the allelic variants of
ERα gene was found in our study subjects; the (C
975G) change was present in half of the study subjects. Although this allele had no direct effect in individual breast cancer risk, it was positively associated with tumor PR (
P for trend=0.04) and ER expression (
P for trend=0.06) and negatively associated with p53 expression (
P for trend=0.02). |
| doi_str_mv | 10.1016/S0304-3835(01)00861-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71489234</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0304383501008618</els_id><sourcerecordid>71489234</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-30eafed93ae72ef2f79390e6c79d2fadaf59d076c1ad400093db15b95fc0a0de3</originalsourceid><addsrcrecordid>eNqFkFFLHDEUhYO06Gr9CZZAUdqHaW8mk8nkSYq0VRBaaPscssmNGzszGZNZwX_frLso-OLThct3DoePkBMGnxmw9stv4NBUvOPiI7BPAF3Lqm6PLFgn60qqDt6QxRNyQA5zvgUA0UixTw4Y61pZQ70gl79i_zDENK1CHjINI51XSDHPKd7gSBNanOaYKtNPK0PLC6kZHV0mNHmm1owWE00h_3tH3nrTZzze3SPy9_u3PxeX1fXPH1cXX68r29Rsrjig8egUNyhr9LWXiivA1krlam-c8UI5kK1lxjVlsOJuycRSCW_BgEN-RM62vVOKd-syVA8hW-x7M2JcZy1Z06maNwX88AK8jes0lm2aCRC8ZSA3lNhSNsWcE3o9pTCY9KAZ6I1o_ShabyxqYPpRtO5K7v2ufb0c0D2ndmYLcLoDTLam96moCvmZ40IwDrxw51sOi7T7gElnG7BodaHIn7WL4ZUp_wGGz5ne</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1505361074</pqid></control><display><type>article</type><title>Polymorphisms in the estrogen receptor-alpha gene and breast cancer risk</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Kang, Hee-Joon ; Kim, Sung-Won ; Kim, Hee Joung ; Ahn, Soo-Jung ; Bae, Ji-Yeon ; Park, Sue Kyung ; Kang, Daehee ; Hirvonen, Ari ; Choe, Kuk Jin ; Noh, Dong-Young</creator><creatorcontrib>Kang, Hee-Joon ; Kim, Sung-Won ; Kim, Hee Joung ; Ahn, Soo-Jung ; Bae, Ji-Yeon ; Park, Sue Kyung ; Kang, Daehee ; Hirvonen, Ari ; Choe, Kuk Jin ; Noh, Dong-Young</creatorcontrib><description>The estrogen receptor-alpha (ERα) has been known to play a role in the development and progression of breast cancer. Several genetic polymorphisms in the
ERα gene have been related to breast cancer risk and/or different tumor characteristics. In this study, PCR and direct sequencing based methods were used to examine this issue further in a Korean study population consisting of 155 women, 110 with breast cancer and 45 without cancer. We also assessed the potential role of the
ERα genotype in ER, PR, p53, c-erbB2, and bcl-2 expression. Only one of the allelic variants of
ERα gene was found in our study subjects; the (C
975G) change was present in half of the study subjects. Although this allele had no direct effect in individual breast cancer risk, it was positively associated with tumor PR (
P for trend=0.04) and ER expression (
P for trend=0.06) and negatively associated with p53 expression (
P for trend=0.02).</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(01)00861-8</identifier><identifier>PMID: 11867202</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Aged ; Alleles ; Biological and medical sciences ; Breast cancer ; Breast Neoplasms - etiology ; Breast Neoplasms - genetics ; Breast Neoplasms - metabolism ; Cell cycle ; Deoxyribonucleic acid ; DNA ; DNA repair ; Estrogen Receptor alpha ; Estrogens ; Female ; Genes ; Gynecology. Andrology. Obstetrics ; Hormone replacement therapy ; Humans ; Korea ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Neoplasm Proteins - biosynthesis ; Neoplasm Proteins - genetics ; Polymorphism, Single Nucleotide ; Receptors, Estrogen - genetics ; Risk ; Signal transduction ; Single nucleotide polymorphism ; Studies ; Tumors ; Womens health</subject><ispartof>Cancer letters, 2002-04, Vol.178 (2), p.175-180</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Elsevier Limited Apr 25, 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-30eafed93ae72ef2f79390e6c79d2fadaf59d076c1ad400093db15b95fc0a0de3</citedby><cites>FETCH-LOGICAL-c421t-30eafed93ae72ef2f79390e6c79d2fadaf59d076c1ad400093db15b95fc0a0de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3835(01)00861-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13551303$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11867202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Hee-Joon</creatorcontrib><creatorcontrib>Kim, Sung-Won</creatorcontrib><creatorcontrib>Kim, Hee Joung</creatorcontrib><creatorcontrib>Ahn, Soo-Jung</creatorcontrib><creatorcontrib>Bae, Ji-Yeon</creatorcontrib><creatorcontrib>Park, Sue Kyung</creatorcontrib><creatorcontrib>Kang, Daehee</creatorcontrib><creatorcontrib>Hirvonen, Ari</creatorcontrib><creatorcontrib>Choe, Kuk Jin</creatorcontrib><creatorcontrib>Noh, Dong-Young</creatorcontrib><title>Polymorphisms in the estrogen receptor-alpha gene and breast cancer risk</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>The estrogen receptor-alpha (ERα) has been known to play a role in the development and progression of breast cancer. Several genetic polymorphisms in the
ERα gene have been related to breast cancer risk and/or different tumor characteristics. In this study, PCR and direct sequencing based methods were used to examine this issue further in a Korean study population consisting of 155 women, 110 with breast cancer and 45 without cancer. We also assessed the potential role of the
ERα genotype in ER, PR, p53, c-erbB2, and bcl-2 expression. Only one of the allelic variants of
ERα gene was found in our study subjects; the (C
975G) change was present in half of the study subjects. Although this allele had no direct effect in individual breast cancer risk, it was positively associated with tumor PR (
P for trend=0.04) and ER expression (
P for trend=0.06) and negatively associated with p53 expression (
P for trend=0.02).</description><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - etiology</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - metabolism</subject><subject>Cell cycle</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA repair</subject><subject>Estrogen Receptor alpha</subject><subject>Estrogens</subject><subject>Female</subject><subject>Genes</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hormone replacement therapy</subject><subject>Humans</subject><subject>Korea</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Neoplasm Proteins - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Receptors, Estrogen - genetics</subject><subject>Risk</subject><subject>Signal transduction</subject><subject>Single nucleotide polymorphism</subject><subject>Studies</subject><subject>Tumors</subject><subject>Womens health</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFFLHDEUhYO06Gr9CZZAUdqHaW8mk8nkSYq0VRBaaPscssmNGzszGZNZwX_frLso-OLThct3DoePkBMGnxmw9stv4NBUvOPiI7BPAF3Lqm6PLFgn60qqDt6QxRNyQA5zvgUA0UixTw4Y61pZQ70gl79i_zDENK1CHjINI51XSDHPKd7gSBNanOaYKtNPK0PLC6kZHV0mNHmm1owWE00h_3tH3nrTZzze3SPy9_u3PxeX1fXPH1cXX68r29Rsrjig8egUNyhr9LWXiivA1krlam-c8UI5kK1lxjVlsOJuycRSCW_BgEN-RM62vVOKd-syVA8hW-x7M2JcZy1Z06maNwX88AK8jes0lm2aCRC8ZSA3lNhSNsWcE3o9pTCY9KAZ6I1o_ShabyxqYPpRtO5K7v2ufb0c0D2ndmYLcLoDTLam96moCvmZ40IwDrxw51sOi7T7gElnG7BodaHIn7WL4ZUp_wGGz5ne</recordid><startdate>20020425</startdate><enddate>20020425</enddate><creator>Kang, Hee-Joon</creator><creator>Kim, Sung-Won</creator><creator>Kim, Hee Joung</creator><creator>Ahn, Soo-Jung</creator><creator>Bae, Ji-Yeon</creator><creator>Park, Sue Kyung</creator><creator>Kang, Daehee</creator><creator>Hirvonen, Ari</creator><creator>Choe, Kuk Jin</creator><creator>Noh, Dong-Young</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20020425</creationdate><title>Polymorphisms in the estrogen receptor-alpha gene and breast cancer risk</title><author>Kang, Hee-Joon ; Kim, Sung-Won ; Kim, Hee Joung ; Ahn, Soo-Jung ; Bae, Ji-Yeon ; Park, Sue Kyung ; Kang, Daehee ; Hirvonen, Ari ; Choe, Kuk Jin ; Noh, Dong-Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-30eafed93ae72ef2f79390e6c79d2fadaf59d076c1ad400093db15b95fc0a0de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - etiology</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - metabolism</topic><topic>Cell cycle</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA repair</topic><topic>Estrogen Receptor alpha</topic><topic>Estrogens</topic><topic>Female</topic><topic>Genes</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hormone replacement therapy</topic><topic>Humans</topic><topic>Korea</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Neoplasm Proteins - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Receptors, Estrogen - genetics</topic><topic>Risk</topic><topic>Signal transduction</topic><topic>Single nucleotide polymorphism</topic><topic>Studies</topic><topic>Tumors</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Hee-Joon</creatorcontrib><creatorcontrib>Kim, Sung-Won</creatorcontrib><creatorcontrib>Kim, Hee Joung</creatorcontrib><creatorcontrib>Ahn, Soo-Jung</creatorcontrib><creatorcontrib>Bae, Ji-Yeon</creatorcontrib><creatorcontrib>Park, Sue Kyung</creatorcontrib><creatorcontrib>Kang, Daehee</creatorcontrib><creatorcontrib>Hirvonen, Ari</creatorcontrib><creatorcontrib>Choe, Kuk Jin</creatorcontrib><creatorcontrib>Noh, Dong-Young</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Hee-Joon</au><au>Kim, Sung-Won</au><au>Kim, Hee Joung</au><au>Ahn, Soo-Jung</au><au>Bae, Ji-Yeon</au><au>Park, Sue Kyung</au><au>Kang, Daehee</au><au>Hirvonen, Ari</au><au>Choe, Kuk Jin</au><au>Noh, Dong-Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms in the estrogen receptor-alpha gene and breast cancer risk</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2002-04-25</date><risdate>2002</risdate><volume>178</volume><issue>2</issue><spage>175</spage><epage>180</epage><pages>175-180</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>The estrogen receptor-alpha (ERα) has been known to play a role in the development and progression of breast cancer. Several genetic polymorphisms in the
ERα gene have been related to breast cancer risk and/or different tumor characteristics. In this study, PCR and direct sequencing based methods were used to examine this issue further in a Korean study population consisting of 155 women, 110 with breast cancer and 45 without cancer. We also assessed the potential role of the
ERα genotype in ER, PR, p53, c-erbB2, and bcl-2 expression. Only one of the allelic variants of
ERα gene was found in our study subjects; the (C
975G) change was present in half of the study subjects. Although this allele had no direct effect in individual breast cancer risk, it was positively associated with tumor PR (
P for trend=0.04) and ER expression (
P for trend=0.06) and negatively associated with p53 expression (
P for trend=0.02).</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11867202</pmid><doi>10.1016/S0304-3835(01)00861-8</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2002-04, Vol.178 (2), p.175-180 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71489234 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Aged Alleles Biological and medical sciences Breast cancer Breast Neoplasms - etiology Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell cycle Deoxyribonucleic acid DNA DNA repair Estrogen Receptor alpha Estrogens Female Genes Gynecology. Andrology. Obstetrics Hormone replacement therapy Humans Korea Mammary gland diseases Medical sciences Middle Aged Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Polymorphism, Single Nucleotide Receptors, Estrogen - genetics Risk Signal transduction Single nucleotide polymorphism Studies Tumors Womens health |
| title | Polymorphisms in the estrogen receptor-alpha gene and breast cancer risk |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T19%3A09%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Polymorphisms%20in%20the%20estrogen%20receptor-alpha%20gene%20and%20breast%20cancer%20risk&rft.jtitle=Cancer%20letters&rft.au=Kang,%20Hee-Joon&rft.date=2002-04-25&rft.volume=178&rft.issue=2&rft.spage=175&rft.epage=180&rft.pages=175-180&rft.issn=0304-3835&rft.eissn=1872-7980&rft.coden=CALEDQ&rft_id=info:doi/10.1016/S0304-3835(01)00861-8&rft_dat=%3Cproquest_cross%3E71489234%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1505361074&rft_id=info:pmid/11867202&rft_els_id=S0304383501008618&rfr_iscdi=true |