Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA

The transcription factor NF-kappaB is activated by the degradation of its inhibitor IkappaBalpha, resulting in its nuclear translocation. However, the mechanism by which nuclear NF-kappaB is subsequently regulated is not clear. Here we demonstrate that NF-kappaB function is regulated by Pin1-mediate...

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Veröffentlicht in:	Molecular cell 2003-12, Vol.12 (6), p.1413-1426
Hauptverfasser:	Ryo, Akihide, Suizu, Futoshi, Yoshida, Yasuhiro, Perrem, Kilian, Liou, Yih-Cherng, Wulf, Gerburg, Rottapel, Robert, Yamaoka, Shoji, Lu, Kun Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Binding Sites Breast Neoplasms - metabolism Breast Neoplasms - pathology Carrier Proteins - metabolism Cells, Cultured Cytokines - metabolism DNA-Binding Proteins - metabolism Female Fibroblasts - cytology Fibroblasts - physiology Humans I-kappa B Kinase I-kappa B Proteins - metabolism Intracellular Signaling Peptides and Proteins Mice Mice, Knockout NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism NF-KappaB Inhibitor alpha NIMA-Interacting Peptidylprolyl Isomerase Peptidylprolyl Isomerase - genetics Peptidylprolyl Isomerase - metabolism Phosphorylation Protein Binding Protein Subunits - metabolism Protein-Serine-Threonine Kinases - metabolism Repressor Proteins - metabolism Signal Transduction - physiology Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins Transcription Factor RelA Transcriptional Activation Ubiquitin - metabolism
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