MICA/NKG2D-mediated immunogene therapy of experimental gliomas

The failure of conventional cancer therapy renders glioblastoma an attractive target for immunotherapy. Tumor cells expressing ligands of the activating immunoreceptor NKG2D stimulate tumor immunity mediated by natural killer (NK), gammadelta T, and CD8(+) T cells. We report that human glioma cells...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2003-12, Vol.63 (24), p.8996-9006
Hauptverfasser:	FRIESE, Manuel A, PLATTEN, Michael, WELLER, Michael, LUTZ, Stefan Z, NAUMANN, Ulrike, AULWURM, Steffen, BISCHOF, Felix, BÜHRING, Hans-Jörg, DICHGANS, Johannes, RAMMENSEE, Hans-Georg, STEINLE, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cancer Vaccines - genetics Cancer Vaccines - immunology Cell Line, Tumor Genetic Therapy - methods Glioma - genetics Glioma - immunology Glioma - metabolism Glioma - therapy Histocompatibility Antigens Class I - biosynthesis Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology Humans Immunotherapy - methods Lymphocyte Activation Medical sciences Mice Mice, Inbred BALB C Mice, Nude NK Cell Lectin-Like Receptor Subfamily K Pharmacology. Drug treatments Receptors, Immunologic - biosynthesis Receptors, Immunologic - genetics Receptors, Immunologic - immunology Receptors, Natural Killer Cell T-Lymphocytes - immunology Transfection Tumors Vaccination Xenograft Model Antitumor Assays
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