Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity
Whereas biallelic neurofibromatosis 1 (NF1) inactivation is observed in NF1-associated gliomas, astrocyte-restricted Nf1 conditional knockout mice do not develop gliomas. These observations suggest that NF1 glioma formation requires additional cellular or genetic conditions. To determine the effect...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2003-12, Vol.63 (24), p.8573-8577 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | Bajenaru, M Livia Hernandez, M Rosario Perry, Arie Zhu, Yuan Parada, Luis F Garbow, Joel R Gutmann, David H |
| description | Whereas biallelic neurofibromatosis 1 (NF1) inactivation is observed in NF1-associated gliomas, astrocyte-restricted Nf1 conditional knockout mice do not develop gliomas. These observations suggest that NF1 glioma formation requires additional cellular or genetic conditions. To determine the effect of an Nf1 heterozygous brain environment on NF1 glioma formation, we generated Nf1+/- mice lacking Nf1 expression in astrocytes. In contrast to astrocyte-restricted Nf1 conditional knockout mice, Nf1+/- mice lacking Nf1 in astrocytes develop optic nerve gliomas. This mouse model demonstrates that Nf1+/- cells contribute to the pathogenesis of gliomas in NF1 and provides a tool for the preclinical evaluation of potential therapeutic interventions for these tumors. |
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This mouse model demonstrates that Nf1+/- cells contribute to the pathogenesis of gliomas in NF1 and provides a tool for the preclinical evaluation of potential therapeutic interventions for these tumors.</description><subject>Animals</subject><subject>Astrocytes - pathology</subject><subject>Astrocytes - physiology</subject><subject>Brain - metabolism</subject><subject>Brain - physiology</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene Silencing</subject><subject>Genes, Neurofibromatosis 1 - physiology</subject><subject>Heterozygote</subject><subject>Humans</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Mice, Transgenic</subject><subject>Neurofibromatosis 1 - complications</subject><subject>Neurofibromatosis 1 - genetics</subject><subject>Neurofibromatosis 1 - pathology</subject><subject>Nf1 gene</subject><subject>Optic Nerve Glioma - genetics</subject><subject>Optic Nerve Glioma - pathology</subject><issn>0008-5472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1OwzAQhH0A0VJ4BeQTt0h2YmfDEVX8SRW9wDnYzjo1SuLWdiqFpyeCcuY0s5pvd6U5I0vGWJVJAfmCXMb4OY-SM3lBFlyUd5KXYkk-tvvkDB0wHJG2nfO9om6gvTNIAx5GFzBSFVPwZkpIXy2nLQ44M8okd1TJ-YGqoflJdFDz7g4TBv81tT66NF2Rc6u6iNcnXZH3x4e39XO22T69rO832S6HPGWao7WoZQNWay44wGwao0tlkQFrUIKseIVgOQjDVGGhEdzkjFuowKpiRW5_7-6DP4wYU927aLDr1IB-jDVwUUkuq3_B-bUsyoLN4M0JHHWPTb0Prldhqv_KK74BNSVryA</recordid><startdate>20031215</startdate><enddate>20031215</enddate><creator>Bajenaru, M Livia</creator><creator>Hernandez, M Rosario</creator><creator>Perry, Arie</creator><creator>Zhu, Yuan</creator><creator>Parada, Luis F</creator><creator>Garbow, Joel R</creator><creator>Gutmann, David H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20031215</creationdate><title>Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity</title><author>Bajenaru, M Livia ; Hernandez, M Rosario ; Perry, Arie ; Zhu, Yuan ; Parada, Luis F ; Garbow, Joel R ; Gutmann, David H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h272t-b1effeb5d7fbb141777fbdcb6afe070de575818e7f174c0a3f7d41c201f787fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Astrocytes - pathology</topic><topic>Astrocytes - physiology</topic><topic>Brain - metabolism</topic><topic>Brain - physiology</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene Silencing</topic><topic>Genes, Neurofibromatosis 1 - physiology</topic><topic>Heterozygote</topic><topic>Humans</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Mice, Transgenic</topic><topic>Neurofibromatosis 1 - complications</topic><topic>Neurofibromatosis 1 - genetics</topic><topic>Neurofibromatosis 1 - pathology</topic><topic>Nf1 gene</topic><topic>Optic Nerve Glioma - genetics</topic><topic>Optic Nerve Glioma - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bajenaru, M Livia</creatorcontrib><creatorcontrib>Hernandez, M Rosario</creatorcontrib><creatorcontrib>Perry, Arie</creatorcontrib><creatorcontrib>Zhu, Yuan</creatorcontrib><creatorcontrib>Parada, Luis F</creatorcontrib><creatorcontrib>Garbow, Joel R</creatorcontrib><creatorcontrib>Gutmann, David H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bajenaru, M Livia</au><au>Hernandez, M Rosario</au><au>Perry, Arie</au><au>Zhu, Yuan</au><au>Parada, Luis F</au><au>Garbow, Joel R</au><au>Gutmann, David H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>2003-12-15</date><risdate>2003</risdate><volume>63</volume><issue>24</issue><spage>8573</spage><epage>8577</epage><pages>8573-8577</pages><issn>0008-5472</issn><abstract>Whereas biallelic neurofibromatosis 1 (NF1) inactivation is observed in NF1-associated gliomas, astrocyte-restricted Nf1 conditional knockout mice do not develop gliomas. These observations suggest that NF1 glioma formation requires additional cellular or genetic conditions. To determine the effect of an Nf1 heterozygous brain environment on NF1 glioma formation, we generated Nf1+/- mice lacking Nf1 expression in astrocytes. In contrast to astrocyte-restricted Nf1 conditional knockout mice, Nf1+/- mice lacking Nf1 in astrocytes develop optic nerve gliomas. This mouse model demonstrates that Nf1+/- cells contribute to the pathogenesis of gliomas in NF1 and provides a tool for the preclinical evaluation of potential therapeutic interventions for these tumors.</abstract><cop>United States</cop><pmid>14695164</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Cancer research (Chicago, Ill.), 2003-12, Vol.63 (24), p.8573-8577 |
| issn | 0008-5472 |
| language | eng |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Astrocytes - pathology Astrocytes - physiology Brain - metabolism Brain - physiology Gene Expression Regulation, Neoplastic Gene Silencing Genes, Neurofibromatosis 1 - physiology Heterozygote Humans Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Neurofibromatosis 1 - complications Neurofibromatosis 1 - genetics Neurofibromatosis 1 - pathology Nf1 gene Optic Nerve Glioma - genetics Optic Nerve Glioma - pathology |
| title | Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity |
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