Intermittent claudication in diabetics: treatment with exercise and pentoxifylline--a 6-month, controlled, randomized trial

The aims of this study were to evaluate the effect of PXF (1600 mg daily) in diabetic patients with intermittent claudication. Of the 60 included patients, 53 completed the study (27 in the PXF group). There were seven dropouts. The groups were comparable for age, sex distribution, and total walking...

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Veröffentlicht in:Angiology 2002-01, Vol.53 Suppl 1 (1), p.S39-S43
Hauptverfasser: Belcaro, G, Nicolaides, A N, Griffin, M, De Sanctis, M T, Cesarone, M R, Incandela, L, Ippolito, E, Pomante, P, Geroulakos, G, Ramaswami, G
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container_issue 1
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container_title Angiology
container_volume 53 Suppl 1
creator Belcaro, G
Nicolaides, A N
Griffin, M
De Sanctis, M T
Cesarone, M R
Incandela, L
Ippolito, E
Pomante, P
Geroulakos, G
Ramaswami, G
description The aims of this study were to evaluate the effect of PXF (1600 mg daily) in diabetic patients with intermittent claudication. Of the 60 included patients, 53 completed the study (27 in the PXF group). There were seven dropouts. The groups were comparable for age, sex distribution, and total walking distance (TWD), and risk factors. There was an increase in TWD at 3 and 6 months in both groups (p
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Of the 60 included patients, 53 completed the study (27 in the PXF group). There were seven dropouts. The groups were comparable for age, sex distribution, and total walking distance (TWD), and risk factors. There was an increase in TWD at 3 and 6 months in both groups (p&lt;0.05) possibly due to exercise. However the increase (both absolute and percentage) in TWD was significantly larger in the PXF group. At 6 months, PXF produced a 292% increase in TWD (vs 180% produced by placebo) (p&lt;0.02). The excess increase produced by PXF treatment was 112% at 6 months in comparison with placebo (p&lt;0.02). Treatment was well tolerated. 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subjects Aged
Blood Pressure - drug effects
Blood Pressure - physiology
Care and treatment
Diabetes
Diabetes Complications
Diabetes Mellitus - physiopathology
Diabetics
Double-Blind Method
Drug therapy
Evaluation
Exercise Test
Exercise Therapy
Female
Health aspects
Humans
Intermittent claudication
Intermittent Claudication - complications
Intermittent Claudication - physiopathology
Intermittent Claudication - therapy
Male
Middle Aged
Patient Compliance
Pentoxifylline
Pentoxifylline - therapeutic use
Time Factors
Treatment Outcome
Vasodilator Agents - therapeutic use
Walking - physiology
title Intermittent claudication in diabetics: treatment with exercise and pentoxifylline--a 6-month, controlled, randomized trial
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