Intermittent claudication in diabetics: treatment with exercise and pentoxifylline--a 6-month, controlled, randomized trial
The aims of this study were to evaluate the effect of PXF (1600 mg daily) in diabetic patients with intermittent claudication. Of the 60 included patients, 53 completed the study (27 in the PXF group). There were seven dropouts. The groups were comparable for age, sex distribution, and total walking...
Gespeichert in:
Veröffentlicht in: | Angiology 2002-01, Vol.53 Suppl 1 (1), p.S39-S43 |
---|---|
Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | S43 |
---|---|
container_issue | 1 |
container_start_page | S39 |
container_title | Angiology |
container_volume | 53 Suppl 1 |
creator | Belcaro, G Nicolaides, A N Griffin, M De Sanctis, M T Cesarone, M R Incandela, L Ippolito, E Pomante, P Geroulakos, G Ramaswami, G |
description | The aims of this study were to evaluate the effect of PXF (1600 mg daily) in diabetic patients with intermittent claudication. Of the 60 included patients, 53 completed the study (27 in the PXF group). There were seven dropouts. The groups were comparable for age, sex distribution, and total walking distance (TWD), and risk factors. There was an increase in TWD at 3 and 6 months in both groups (p |
format | Article |
fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_71484804</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A83564653</galeid><sourcerecordid>A83564653</sourcerecordid><originalsourceid>FETCH-LOGICAL-g338t-dc56afd15c4cdc9a75070a1fe39a1a36c1f5c9d070f69f8a26cdd879f66e9dd23</originalsourceid><addsrcrecordid>eNpt0U1r3DAQBmBTWppN2r9QRA89rcBaWbLVWwhJEwj00p7NRBptJsjSVpbJ15-vQhMawqLDoJeHl0F616yE6VouVN-9b1Zt20ouhekPmsN5vqlXJVr9sTkQYtBqkGrVPF7EgnmiUjAWZgMsjiwUSpFRZI7gCgvZ-TsrGaFMT-iWyjXDO8yWZmQQHdvVON2Rvw-BInIOTPMpxXK9ZraOnEJAt2a52jTRA7raRhA-NR88hBk_P8-j5vfZ6a-Tc37588fFyfEl30o5FO6s0uCdULazzhroVdu3IDxKAwKktsIra1wNvTZ-gI22zg298VqjcW4jj5pv_3p3Of1ZcC7jRLPFECBiWuaxF93QDW1X4dc38CYtOdbdxs2mG6SWRv9HWwg4UvSpZLBPjeNxfVLdaSUrWu9BW4yYIaSInmr8mvM9vB6HE9l9_svzosvVhG7cZZog348v_yr_AqHRoJI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>224836396</pqid></control><display><type>article</type><title>Intermittent claudication in diabetics: treatment with exercise and pentoxifylline--a 6-month, controlled, randomized trial</title><source>Access via SAGE</source><source>MEDLINE</source><creator>Belcaro, G ; Nicolaides, A N ; Griffin, M ; De Sanctis, M T ; Cesarone, M R ; Incandela, L ; Ippolito, E ; Pomante, P ; Geroulakos, G ; Ramaswami, G</creator><creatorcontrib>Belcaro, G ; Nicolaides, A N ; Griffin, M ; De Sanctis, M T ; Cesarone, M R ; Incandela, L ; Ippolito, E ; Pomante, P ; Geroulakos, G ; Ramaswami, G</creatorcontrib><description>The aims of this study were to evaluate the effect of PXF (1600 mg daily) in diabetic patients with intermittent claudication. Of the 60 included patients, 53 completed the study (27 in the PXF group). There were seven dropouts. The groups were comparable for age, sex distribution, and total walking distance (TWD), and risk factors. There was an increase in TWD at 3 and 6 months in both groups (p<0.05) possibly due to exercise. However the increase (both absolute and percentage) in TWD was significantly larger in the PXF group. At 6 months, PXF produced a 292% increase in TWD (vs 180% produced by placebo) (p<0.02). The excess increase produced by PXF treatment was 112% at 6 months in comparison with placebo (p<0.02). Treatment was well tolerated. Between-group analysis favors PXF considering TWD, and results indicate good efficacy and tolerability.</description><identifier>ISSN: 0003-3197</identifier><identifier>EISSN: 1940-1574</identifier><identifier>PMID: 11865835</identifier><language>eng</language><publisher>United States: Sage Publications, Inc</publisher><subject>Aged ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Care and treatment ; Diabetes ; Diabetes Complications ; Diabetes Mellitus - physiopathology ; Diabetics ; Double-Blind Method ; Drug therapy ; Evaluation ; Exercise Test ; Exercise Therapy ; Female ; Health aspects ; Humans ; Intermittent claudication ; Intermittent Claudication - complications ; Intermittent Claudication - physiopathology ; Intermittent Claudication - therapy ; Male ; Middle Aged ; Patient Compliance ; Pentoxifylline ; Pentoxifylline - therapeutic use ; Time Factors ; Treatment Outcome ; Vasodilator Agents - therapeutic use ; Walking - physiology</subject><ispartof>Angiology, 2002-01, Vol.53 Suppl 1 (1), p.S39-S43</ispartof><rights>COPYRIGHT 2002 Sage Publications, Inc.</rights><rights>Copyright Westminster Publications, Inc. Jan/Feb 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11865835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belcaro, G</creatorcontrib><creatorcontrib>Nicolaides, A N</creatorcontrib><creatorcontrib>Griffin, M</creatorcontrib><creatorcontrib>De Sanctis, M T</creatorcontrib><creatorcontrib>Cesarone, M R</creatorcontrib><creatorcontrib>Incandela, L</creatorcontrib><creatorcontrib>Ippolito, E</creatorcontrib><creatorcontrib>Pomante, P</creatorcontrib><creatorcontrib>Geroulakos, G</creatorcontrib><creatorcontrib>Ramaswami, G</creatorcontrib><title>Intermittent claudication in diabetics: treatment with exercise and pentoxifylline--a 6-month, controlled, randomized trial</title><title>Angiology</title><addtitle>Angiology</addtitle><description>The aims of this study were to evaluate the effect of PXF (1600 mg daily) in diabetic patients with intermittent claudication. Of the 60 included patients, 53 completed the study (27 in the PXF group). There were seven dropouts. The groups were comparable for age, sex distribution, and total walking distance (TWD), and risk factors. There was an increase in TWD at 3 and 6 months in both groups (p<0.05) possibly due to exercise. However the increase (both absolute and percentage) in TWD was significantly larger in the PXF group. At 6 months, PXF produced a 292% increase in TWD (vs 180% produced by placebo) (p<0.02). The excess increase produced by PXF treatment was 112% at 6 months in comparison with placebo (p<0.02). Treatment was well tolerated. Between-group analysis favors PXF considering TWD, and results indicate good efficacy and tolerability.</description><subject>Aged</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Care and treatment</subject><subject>Diabetes</subject><subject>Diabetes Complications</subject><subject>Diabetes Mellitus - physiopathology</subject><subject>Diabetics</subject><subject>Double-Blind Method</subject><subject>Drug therapy</subject><subject>Evaluation</subject><subject>Exercise Test</subject><subject>Exercise Therapy</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Intermittent claudication</subject><subject>Intermittent Claudication - complications</subject><subject>Intermittent Claudication - physiopathology</subject><subject>Intermittent Claudication - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patient Compliance</subject><subject>Pentoxifylline</subject><subject>Pentoxifylline - therapeutic use</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Vasodilator Agents - therapeutic use</subject><subject>Walking - physiology</subject><issn>0003-3197</issn><issn>1940-1574</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpt0U1r3DAQBmBTWppN2r9QRA89rcBaWbLVWwhJEwj00p7NRBptJsjSVpbJ15-vQhMawqLDoJeHl0F616yE6VouVN-9b1Zt20ouhekPmsN5vqlXJVr9sTkQYtBqkGrVPF7EgnmiUjAWZgMsjiwUSpFRZI7gCgvZ-TsrGaFMT-iWyjXDO8yWZmQQHdvVON2Rvw-BInIOTPMpxXK9ZraOnEJAt2a52jTRA7raRhA-NR88hBk_P8-j5vfZ6a-Tc37588fFyfEl30o5FO6s0uCdULazzhroVdu3IDxKAwKktsIra1wNvTZ-gI22zg298VqjcW4jj5pv_3p3Of1ZcC7jRLPFECBiWuaxF93QDW1X4dc38CYtOdbdxs2mG6SWRv9HWwg4UvSpZLBPjeNxfVLdaSUrWu9BW4yYIaSInmr8mvM9vB6HE9l9_svzosvVhG7cZZog348v_yr_AqHRoJI</recordid><startdate>200201</startdate><enddate>200201</enddate><creator>Belcaro, G</creator><creator>Nicolaides, A N</creator><creator>Griffin, M</creator><creator>De Sanctis, M T</creator><creator>Cesarone, M R</creator><creator>Incandela, L</creator><creator>Ippolito, E</creator><creator>Pomante, P</creator><creator>Geroulakos, G</creator><creator>Ramaswami, G</creator><general>Sage Publications, Inc</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200201</creationdate><title>Intermittent claudication in diabetics: treatment with exercise and pentoxifylline--a 6-month, controlled, randomized trial</title><author>Belcaro, G ; Nicolaides, A N ; Griffin, M ; De Sanctis, M T ; Cesarone, M R ; Incandela, L ; Ippolito, E ; Pomante, P ; Geroulakos, G ; Ramaswami, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g338t-dc56afd15c4cdc9a75070a1fe39a1a36c1f5c9d070f69f8a26cdd879f66e9dd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Care and treatment</topic><topic>Diabetes</topic><topic>Diabetes Complications</topic><topic>Diabetes Mellitus - physiopathology</topic><topic>Diabetics</topic><topic>Double-Blind Method</topic><topic>Drug therapy</topic><topic>Evaluation</topic><topic>Exercise Test</topic><topic>Exercise Therapy</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Intermittent claudication</topic><topic>Intermittent Claudication - complications</topic><topic>Intermittent Claudication - physiopathology</topic><topic>Intermittent Claudication - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patient Compliance</topic><topic>Pentoxifylline</topic><topic>Pentoxifylline - therapeutic use</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Vasodilator Agents - therapeutic use</topic><topic>Walking - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belcaro, G</creatorcontrib><creatorcontrib>Nicolaides, A N</creatorcontrib><creatorcontrib>Griffin, M</creatorcontrib><creatorcontrib>De Sanctis, M T</creatorcontrib><creatorcontrib>Cesarone, M R</creatorcontrib><creatorcontrib>Incandela, L</creatorcontrib><creatorcontrib>Ippolito, E</creatorcontrib><creatorcontrib>Pomante, P</creatorcontrib><creatorcontrib>Geroulakos, G</creatorcontrib><creatorcontrib>Ramaswami, G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Angiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belcaro, G</au><au>Nicolaides, A N</au><au>Griffin, M</au><au>De Sanctis, M T</au><au>Cesarone, M R</au><au>Incandela, L</au><au>Ippolito, E</au><au>Pomante, P</au><au>Geroulakos, G</au><au>Ramaswami, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intermittent claudication in diabetics: treatment with exercise and pentoxifylline--a 6-month, controlled, randomized trial</atitle><jtitle>Angiology</jtitle><addtitle>Angiology</addtitle><date>2002-01</date><risdate>2002</risdate><volume>53 Suppl 1</volume><issue>1</issue><spage>S39</spage><epage>S43</epage><pages>S39-S43</pages><issn>0003-3197</issn><eissn>1940-1574</eissn><abstract>The aims of this study were to evaluate the effect of PXF (1600 mg daily) in diabetic patients with intermittent claudication. Of the 60 included patients, 53 completed the study (27 in the PXF group). There were seven dropouts. The groups were comparable for age, sex distribution, and total walking distance (TWD), and risk factors. There was an increase in TWD at 3 and 6 months in both groups (p<0.05) possibly due to exercise. However the increase (both absolute and percentage) in TWD was significantly larger in the PXF group. At 6 months, PXF produced a 292% increase in TWD (vs 180% produced by placebo) (p<0.02). The excess increase produced by PXF treatment was 112% at 6 months in comparison with placebo (p<0.02). Treatment was well tolerated. Between-group analysis favors PXF considering TWD, and results indicate good efficacy and tolerability.</abstract><cop>United States</cop><pub>Sage Publications, Inc</pub><pmid>11865835</pmid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0003-3197 |
ispartof | Angiology, 2002-01, Vol.53 Suppl 1 (1), p.S39-S43 |
issn | 0003-3197 1940-1574 |
language | eng |
recordid | cdi_proquest_miscellaneous_71484804 |
source | Access via SAGE; MEDLINE |
subjects | Aged Blood Pressure - drug effects Blood Pressure - physiology Care and treatment Diabetes Diabetes Complications Diabetes Mellitus - physiopathology Diabetics Double-Blind Method Drug therapy Evaluation Exercise Test Exercise Therapy Female Health aspects Humans Intermittent claudication Intermittent Claudication - complications Intermittent Claudication - physiopathology Intermittent Claudication - therapy Male Middle Aged Patient Compliance Pentoxifylline Pentoxifylline - therapeutic use Time Factors Treatment Outcome Vasodilator Agents - therapeutic use Walking - physiology |
title | Intermittent claudication in diabetics: treatment with exercise and pentoxifylline--a 6-month, controlled, randomized trial |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T22%3A50%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intermittent%20claudication%20in%20diabetics:%20treatment%20with%20exercise%20and%20pentoxifylline--a%206-month,%20controlled,%20randomized%20trial&rft.jtitle=Angiology&rft.au=Belcaro,%20G&rft.date=2002-01&rft.volume=53%20Suppl%201&rft.issue=1&rft.spage=S39&rft.epage=S43&rft.pages=S39-S43&rft.issn=0003-3197&rft.eissn=1940-1574&rft_id=info:doi/&rft_dat=%3Cgale_proqu%3EA83564653%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=224836396&rft_id=info:pmid/11865835&rft_galeid=A83564653&rfr_iscdi=true |