The role of mast cells in host defense and their subversion by bacterial pathogens
Mast cells (MCs) play a prominent role in the early immune response to invading pathogenic bacteria. This newly discovered role for MCs involves the release of chemoattractants that recruit neutrophils and the direct phagocytosis and killing of opsonized bacteria. Whereas these activities are clearl...
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| Veröffentlicht in: | Trends in Immunology 2002-03, Vol.23 (3), p.151-158 |
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| container_title | Trends in Immunology |
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| creator | Féger, Frédéric Varadaradjalou, Sonia Gao, Zhimin Abraham, Soman N. Arock, Michel |
| description | Mast cells (MCs) play a prominent role in the early immune response to invading pathogenic bacteria. This newly discovered role for MCs involves the release of chemoattractants that recruit neutrophils and the direct phagocytosis and killing of opsonized bacteria. Whereas these activities are clearly beneficial to the host, certain pathogens have evolved mechanisms to evoke anomalous MC responses to the detriment of the host. These include evoking phagocytosis without killing of unopsonized bacteria and the production of toxins that corrupt the release of mediators by MCs. Elucidating how pathogens subvert the activities of MCs could provide clues to limiting the pathological activities of these cells during infectious diseases.
Mast cells are beneficial for immune defense against bacterial pathogens but also, might be detrimental to the host in such circumstances. Thus, elucidating their precise role in bacterial infections is a challenge for the near future. |
| doi_str_mv | 10.1016/S1471-4906(01)02156-1 |
| format | Article |
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Mast cells are beneficial for immune defense against bacterial pathogens but also, might be detrimental to the host in such circumstances. Thus, elucidating their precise role in bacterial infections is a challenge for the near future.</description><subject>Animals</subject><subject>bacteria</subject><subject>Bacteria - metabolism</subject><subject>Bacteria - pathogenicity</subject><subject>Bacterial Infections - immunology</subject><subject>Cell Culture Techniques</subject><subject>Humans</subject><subject>innate immunity</subject><subject>mast cells</subject><subject>Mast Cells - immunology</subject><subject>Mast Cells - ultrastructure</subject><subject>Mice</subject><subject>Models, Immunological</subject><subject>phagocytosis</subject><subject>receptors</subject><subject>TNF-α</subject><issn>1471-4906</issn><issn>1471-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAMgCMEYuPxE0A5ITgU4jZt0hNCEy8JCYnHOUpThwV1zUi6Sfv3ZGyCIyfH1ufY_gg5AXYJDKqrV-ACMl6z6pzBBcuhrDLYIeNtWcLu75tVI3IQ4ydjUAoh9skIQFZccj4mL29TpMF3SL2lMx0HarDrInU9nfqUtWixj0h139Jhii7QuGiWGKLzPW1WtNFmwOB0R-d6mPqPBB-RPau7iMfbeEje727fJg_Z0_P94-TmKTOc8yGTaPJaMwsGuamN0RKLhmmZVqu5LCpgtswNCGMLa6sCWmxNqukatShbWReH5Gzz7zz4rwXGQc1cXG-ve_SLqASkE4WQ_4IgCwZ5zhNYbkATfIwBrZoHN9NhpYCptXX1Y12tlSoG6se6gtR3uh2waGbY_nVtNSfgegNg8rF0GFQ0DnuDrQtoBtV698-IbwNHkdw</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Féger, Frédéric</creator><creator>Varadaradjalou, Sonia</creator><creator>Gao, Zhimin</creator><creator>Abraham, Soman N.</creator><creator>Arock, Michel</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>The role of mast cells in host defense and their subversion by bacterial pathogens</title><author>Féger, Frédéric ; Varadaradjalou, Sonia ; Gao, Zhimin ; Abraham, Soman N. ; Arock, Michel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-8ec29a0f1ce4c9cca8e3b0a81869483610f52c17cf3ff631dedc10fa9ea75d893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>bacteria</topic><topic>Bacteria - metabolism</topic><topic>Bacteria - pathogenicity</topic><topic>Bacterial Infections - immunology</topic><topic>Cell Culture Techniques</topic><topic>Humans</topic><topic>innate immunity</topic><topic>mast cells</topic><topic>Mast Cells - immunology</topic><topic>Mast Cells - ultrastructure</topic><topic>Mice</topic><topic>Models, Immunological</topic><topic>phagocytosis</topic><topic>receptors</topic><topic>TNF-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Féger, Frédéric</creatorcontrib><creatorcontrib>Varadaradjalou, Sonia</creatorcontrib><creatorcontrib>Gao, Zhimin</creatorcontrib><creatorcontrib>Abraham, Soman N.</creatorcontrib><creatorcontrib>Arock, Michel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Féger, Frédéric</au><au>Varadaradjalou, Sonia</au><au>Gao, Zhimin</au><au>Abraham, Soman N.</au><au>Arock, Michel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of mast cells in host defense and their subversion by bacterial pathogens</atitle><jtitle>Trends in Immunology</jtitle><addtitle>Trends Immunol</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>23</volume><issue>3</issue><spage>151</spage><epage>158</epage><pages>151-158</pages><issn>1471-4906</issn><eissn>1471-4981</eissn><abstract>Mast cells (MCs) play a prominent role in the early immune response to invading pathogenic bacteria. 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Mast cells are beneficial for immune defense against bacterial pathogens but also, might be detrimental to the host in such circumstances. Thus, elucidating their precise role in bacterial infections is a challenge for the near future.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>11864844</pmid><doi>10.1016/S1471-4906(01)02156-1</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals bacteria Bacteria - metabolism Bacteria - pathogenicity Bacterial Infections - immunology Cell Culture Techniques Humans innate immunity mast cells Mast Cells - immunology Mast Cells - ultrastructure Mice Models, Immunological phagocytosis receptors TNF-α |
| title | The role of mast cells in host defense and their subversion by bacterial pathogens |
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