Intestinal absorption and metabolism of retinoyl β-glucuronide in humans, and of 15-[ 14C]-retinoyl β-glucuronide in rats of different vitamin A status
In order to prove the hypothesis that humans and animals with adequate vitamin A status do not absorb and metabolize orally administered all-trans retinoyl β-glucuronide, unlabeled retinoyl glucuronide (0.1 mmol) was orally dosed to fasting well-nourished young men. Neither retinoyl glucuronide nor...
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| Veröffentlicht in: | The Journal of nutritional biochemistry 2003-12, Vol.14 (12), p.703-709 |
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| creator | Goswami, Bhabesh C Reida, Abigail K Ivanoff, Kristi D Barua, Arun B Olson, James A |
| description | In order to prove the hypothesis that humans and animals with adequate vitamin A status do not absorb and metabolize orally administered all-trans retinoyl β-glucuronide, unlabeled retinoyl glucuronide (0.1 mmol) was orally dosed to fasting well-nourished young men. Neither retinoyl glucuronide nor retinoic acid, a possible metabolite, appeared in the blood within 12 h after ingestion. Next, radiolabeled all-trans 15-[
14C]-retinoyl β-glucuronide was chemically synthesized by a new procedure, and fed orally to rats of different vitamin A status. Analysis of blood and other tissues 5 or 24 h after the dose, showed the presence of radioactivity (∼ 0.5%) in the blood of vitamin A deficient rats, but not in sufficient rats. Livers of all rats contained small, but detectable amounts (0.3 to 1.1% of the dose) of radioactivity. The accumulation of radioactivity in the liver was highest in deficient rats. Analysis of the retinoids showed that the radioactivity in serum and liver was due to retinoic acid formed from retinoyl glucuronide. Within 24 h after the dose, 31 to 40% of the administered radioactivity was excreted in the feces, and 2 to 4.7% of the dose was excreted in the urine. Results of the present studies show that oral administration of retinoyl β-glucuronide did not give rise to detectable changes in blood retinoyl glucuronide and/or retinoic acid concentrations in humans or rats with adequate vitamin A status. |
| doi_str_mv | 10.1016/j.jnutbio.2003.08.008 |
| format | Article |
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14C]-retinoyl β-glucuronide was chemically synthesized by a new procedure, and fed orally to rats of different vitamin A status. Analysis of blood and other tissues 5 or 24 h after the dose, showed the presence of radioactivity (∼ 0.5%) in the blood of vitamin A deficient rats, but not in sufficient rats. Livers of all rats contained small, but detectable amounts (0.3 to 1.1% of the dose) of radioactivity. The accumulation of radioactivity in the liver was highest in deficient rats. Analysis of the retinoids showed that the radioactivity in serum and liver was due to retinoic acid formed from retinoyl glucuronide. Within 24 h after the dose, 31 to 40% of the administered radioactivity was excreted in the feces, and 2 to 4.7% of the dose was excreted in the urine. Results of the present studies show that oral administration of retinoyl β-glucuronide did not give rise to detectable changes in blood retinoyl glucuronide and/or retinoic acid concentrations in humans or rats with adequate vitamin A status.</description><identifier>ISSN: 0955-2863</identifier><identifier>EISSN: 1873-4847</identifier><identifier>DOI: 10.1016/j.jnutbio.2003.08.008</identifier><identifier>PMID: 14690762</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Absorption ; Animals ; Biological and medical sciences ; Carbon Radioisotopes - analysis ; Chromatography, High Pressure Liquid ; Feces - chemistry ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Humans ; Intestinal Absorption ; Liver - chemistry ; Male ; Rats ; Rats, Sprague-Dawley ; Retinoic acid ; Retinoids - analysis ; Retinoyl β-glucuronide ; Tretinoin - analogs & derivatives ; Tretinoin - blood ; Tretinoin - metabolism ; Tretinoin - pharmacokinetics ; Urine - chemistry ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin A - blood</subject><ispartof>The Journal of nutritional biochemistry, 2003-12, Vol.14 (12), p.703-709</ispartof><rights>2003 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-3de4a58d4a125c55d87f2d90027ca004970ff07176dc148183e5a221be8d17493</citedby><cites>FETCH-LOGICAL-c391t-3de4a58d4a125c55d87f2d90027ca004970ff07176dc148183e5a221be8d17493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jnutbio.2003.08.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15383402$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14690762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goswami, Bhabesh C</creatorcontrib><creatorcontrib>Reida, Abigail K</creatorcontrib><creatorcontrib>Ivanoff, Kristi D</creatorcontrib><creatorcontrib>Barua, Arun B</creatorcontrib><creatorcontrib>Olson, James A</creatorcontrib><title>Intestinal absorption and metabolism of retinoyl β-glucuronide in humans, and of 15-[ 14C]-retinoyl β-glucuronide in rats of different vitamin A status</title><title>The Journal of nutritional biochemistry</title><addtitle>J Nutr Biochem</addtitle><description>In order to prove the hypothesis that humans and animals with adequate vitamin A status do not absorb and metabolize orally administered all-trans retinoyl β-glucuronide, unlabeled retinoyl glucuronide (0.1 mmol) was orally dosed to fasting well-nourished young men. Neither retinoyl glucuronide nor retinoic acid, a possible metabolite, appeared in the blood within 12 h after ingestion. Next, radiolabeled all-trans 15-[
14C]-retinoyl β-glucuronide was chemically synthesized by a new procedure, and fed orally to rats of different vitamin A status. Analysis of blood and other tissues 5 or 24 h after the dose, showed the presence of radioactivity (∼ 0.5%) in the blood of vitamin A deficient rats, but not in sufficient rats. Livers of all rats contained small, but detectable amounts (0.3 to 1.1% of the dose) of radioactivity. The accumulation of radioactivity in the liver was highest in deficient rats. Analysis of the retinoids showed that the radioactivity in serum and liver was due to retinoic acid formed from retinoyl glucuronide. Within 24 h after the dose, 31 to 40% of the administered radioactivity was excreted in the feces, and 2 to 4.7% of the dose was excreted in the urine. Results of the present studies show that oral administration of retinoyl β-glucuronide did not give rise to detectable changes in blood retinoyl glucuronide and/or retinoic acid concentrations in humans or rats with adequate vitamin A status.</description><subject>Absorption</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carbon Radioisotopes - analysis</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Feces - chemistry</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Intestinal Absorption</subject><subject>Liver - chemistry</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Retinoic acid</subject><subject>Retinoids - analysis</subject><subject>Retinoyl β-glucuronide</subject><subject>Tretinoin - analogs & derivatives</subject><subject>Tretinoin - blood</subject><subject>Tretinoin - metabolism</subject><subject>Tretinoin - pharmacokinetics</subject><subject>Urine - chemistry</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin A - blood</subject><issn>0955-2863</issn><issn>1873-4847</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1u1DAYQC0EokPhCCBv6IqEz4kdOytUjaBUqsSmrBCyHNsBjxJ7sJ1KPUqvwUE4Uz2dSN3RlRd-zz_fQ-gtgZoA6T7u6p1f8uBC3QC0NYgaQDxDGyJ4W1FB-XO0gZ6xqhFde4JepbQDgIay7iU6IbTrgXfNBt1d-mxTdl5NWA0pxH12wWPlDZ5tVkOYXJpxGHG0BQq3E_73t_o1LXqJwTtjsfP49zIrnz48SIUkrPqBCd3-rP7jRJXTATZuHG20PuMbl9Vcds5xyiov6TV6Maop2Tfreoq-f_l8vf1aXX27uNyeX1W67UmuWmOpYsJQRRqmGTOCj43py1e5VgC05zCOwAnvjCZUENFappqGDFYYwmnfnqKz47n7GP4sZRZydknbaVLehiVJXiwKhBeQHUEdQ0rRjnIf3azirSQgD03kTq5N5KGJBCFLk-K9Wy9YhtmaR2uNUID3K6CSVtMYldcuPXKsFS2FA_fpyNkyjhtno0zaWa-tcdHqLE1wTzzlHvKVr9Y</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Goswami, Bhabesh C</creator><creator>Reida, Abigail K</creator><creator>Ivanoff, Kristi D</creator><creator>Barua, Arun B</creator><creator>Olson, James A</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>Intestinal absorption and metabolism of retinoyl β-glucuronide in humans, and of 15-[ 14C]-retinoyl β-glucuronide in rats of different vitamin A status</title><author>Goswami, Bhabesh C ; Reida, Abigail K ; Ivanoff, Kristi D ; Barua, Arun B ; Olson, James A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-3de4a58d4a125c55d87f2d90027ca004970ff07176dc148183e5a221be8d17493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Absorption</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carbon Radioisotopes - analysis</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Feces - chemistry</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Intestinal Absorption</topic><topic>Liver - chemistry</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Retinoic acid</topic><topic>Retinoids - analysis</topic><topic>Retinoyl β-glucuronide</topic><topic>Tretinoin - analogs & derivatives</topic><topic>Tretinoin - blood</topic><topic>Tretinoin - metabolism</topic><topic>Tretinoin - pharmacokinetics</topic><topic>Urine - chemistry</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin A - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goswami, Bhabesh C</creatorcontrib><creatorcontrib>Reida, Abigail K</creatorcontrib><creatorcontrib>Ivanoff, Kristi D</creatorcontrib><creatorcontrib>Barua, Arun B</creatorcontrib><creatorcontrib>Olson, James A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutritional biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goswami, Bhabesh C</au><au>Reida, Abigail K</au><au>Ivanoff, Kristi D</au><au>Barua, Arun B</au><au>Olson, James A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intestinal absorption and metabolism of retinoyl β-glucuronide in humans, and of 15-[ 14C]-retinoyl β-glucuronide in rats of different vitamin A status</atitle><jtitle>The Journal of nutritional biochemistry</jtitle><addtitle>J Nutr Biochem</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>14</volume><issue>12</issue><spage>703</spage><epage>709</epage><pages>703-709</pages><issn>0955-2863</issn><eissn>1873-4847</eissn><abstract>In order to prove the hypothesis that humans and animals with adequate vitamin A status do not absorb and metabolize orally administered all-trans retinoyl β-glucuronide, unlabeled retinoyl glucuronide (0.1 mmol) was orally dosed to fasting well-nourished young men. Neither retinoyl glucuronide nor retinoic acid, a possible metabolite, appeared in the blood within 12 h after ingestion. Next, radiolabeled all-trans 15-[
14C]-retinoyl β-glucuronide was chemically synthesized by a new procedure, and fed orally to rats of different vitamin A status. Analysis of blood and other tissues 5 or 24 h after the dose, showed the presence of radioactivity (∼ 0.5%) in the blood of vitamin A deficient rats, but not in sufficient rats. Livers of all rats contained small, but detectable amounts (0.3 to 1.1% of the dose) of radioactivity. The accumulation of radioactivity in the liver was highest in deficient rats. Analysis of the retinoids showed that the radioactivity in serum and liver was due to retinoic acid formed from retinoyl glucuronide. Within 24 h after the dose, 31 to 40% of the administered radioactivity was excreted in the feces, and 2 to 4.7% of the dose was excreted in the urine. Results of the present studies show that oral administration of retinoyl β-glucuronide did not give rise to detectable changes in blood retinoyl glucuronide and/or retinoic acid concentrations in humans or rats with adequate vitamin A status.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>14690762</pmid><doi>10.1016/j.jnutbio.2003.08.008</doi><tpages>7</tpages></addata></record> |
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| ispartof | The Journal of nutritional biochemistry, 2003-12, Vol.14 (12), p.703-709 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Absorption Animals Biological and medical sciences Carbon Radioisotopes - analysis Chromatography, High Pressure Liquid Feces - chemistry Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Humans Intestinal Absorption Liver - chemistry Male Rats Rats, Sprague-Dawley Retinoic acid Retinoids - analysis Retinoyl β-glucuronide Tretinoin - analogs & derivatives Tretinoin - blood Tretinoin - metabolism Tretinoin - pharmacokinetics Urine - chemistry Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin A - blood |
| title | Intestinal absorption and metabolism of retinoyl β-glucuronide in humans, and of 15-[ 14C]-retinoyl β-glucuronide in rats of different vitamin A status |
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