Development of a sensitive high-performance thin-layer chromatography method for estimation of ranitidine in urine and its application for bioequivalence decision for ranitidine tablet formulations

A sensitive and simple HPTLC method was developed for estimation of ranitidine in human urine. The drug was extracted from urine after basification using dichloromethane. Dichloromethane extract was spotted on silica gel 60 F 254 TLC plate and was developed in a mixture of ethyl acetate–methanol–amm...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2002-02, Vol.767 (1), p.83-91
Hauptverfasser:	Shah, Shailesh A, Rathod, Ishwarsinh S, Savale, Shrinivas S, Patel, Bipin D
Format:	Artikel
Sprache:	eng
Schlagworte:	Area Under Curve Bioequivalence Biological Availability Calibration Chromatography, Thin Layer - methods Histamine H2 Antagonists - pharmacokinetics Histamine H2 Antagonists - urine Humans Ranitidine Ranitidine - pharmacokinetics Ranitidine - urine Reference Values Reproducibility of Results Sensitivity and Specificity Therapeutic Equivalency Urinary excretion
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