Intratumoral immunization with tumor RNA-pulsed dendritic cells confers antitumor immunity in a C57BL/6 pancreatic murine tumor model

Pancreatic tumors lack adequate recruitment of immunocompetent cells, especially dendritic cells (DCs). We have shown previously that coculturing of natural killer-like T cells with DCs transfected with pancreatic tumor cell line-derived RNA reverses pancreatic carcinoma cell resistance by directly...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2003-12, Vol.63 (24), p.8962-8967
Hauptverfasser:	SCHMIDT, Tanja, ZISKE, Carsten, MÄRTEN, Angela, ENDRES, Stefan, TIEMANN, Klaus, SCHMITZ, Volker, GORSCHLÜTER, Marcus, SCHNEIDER, Christof, SAUERBRUCH, Tilman, SCHMIDT-WOLF, Ingo G. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Carcinoma, Pancreatic Ductal - immunology Carcinoma, Pancreatic Ductal - therapy Cell Line, Tumor Dendritic Cells - immunology Female Immunotherapy, Adoptive - methods Injections, Intralesional Lymphocyte Activation - immunology Male Medical sciences Mice Mice, Inbred C57BL Pancreatic Neoplasms - immunology Pancreatic Neoplasms - prevention & control Pancreatic Neoplasms - therapy Pharmacology. Drug treatments RNA, Neoplasm - immunology T-Lymphocytes, Cytotoxic - immunology Tumors
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