Evaluation of the outcomes of short bowel syndrome and indications for intestinal transplantation
Long-term parenteral nutrition (PN) and intestinal transplantation (IT) are life-saving therapies for patients with short bowel syndrome (SBS). However, indications and timing of these therapies are controversial. In this study we aimed to evaluate the indications for IT. Forty-two patients, each wi...
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| Veröffentlicht in: | Transplantation proceedings 2003-12, Vol.35 (8), p.3054-3056 |
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| creator | Atalay, F Ozcay, N Gundogdu, H Orug, T Gungor, A Akoglu, M |
| description | Long-term parenteral nutrition (PN) and intestinal transplantation (IT) are life-saving therapies for patients with short bowel syndrome (SBS). However, indications and timing of these therapies are controversial. In this study we aimed to evaluate the indications for IT. Forty-two patients, each with |
| doi_str_mv | 10.1016/j.transproceed.2003.10.017 |
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However, indications and timing of these therapies are controversial. In this study we aimed to evaluate the indications for IT. Forty-two patients, each with <100 cm of small bowel, were divided into three groups according to the length of remnant: group I patients (n = 18): colon plus 50 to 100 cm of small bowel (SB); group II patients (n = 14): colon plus <50 cm of SB; and group III patients (n = 10): <50 cm of SB without colon. One-year mortality rates for groups I, II, and III were 50%, 72%, and 100%, respectively. All group I survivors developed intestinal adaptation, returning to regular oral feedings at 1 year. Interestingly, three of four surviving patients in group II developed adaptation and were fed an oral short bowel diet (SBD) at 1 year. None of the group III patients survived >1 year, dying due to multiorgan failure in the early postoperative period or from sepsis within 1 year. We conclude that patients with a very short bowel are candidates for IT when stable. If the colon is intact, however, regardless of small bowel remnant length, the patient should be given a chance to develop intestinal adaptation before making the decision for permanent PN or IT.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2003.10.017</identifier><identifier>PMID: 14697978</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Intestines - transplantation ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Parenteral Nutrition, Total ; Retrospective Studies ; Short Bowel Syndrome - complications ; Short Bowel Syndrome - surgery ; Short Bowel Syndrome - therapy ; Stomach, duodenum, intestine, rectum, anus ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Thromboembolism - surgery ; Time Factors ; Transplantation, Homologous ; Treatment Outcome</subject><ispartof>Transplantation proceedings, 2003-12, Vol.35 (8), p.3054-3056</ispartof><rights>2003 Elsevier Science Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-ec66aeeef528b5a07e536ab711aa9ff239556422f9802e95ae8263dda3b3361e3</citedby><cites>FETCH-LOGICAL-c406t-ec66aeeef528b5a07e536ab711aa9ff239556422f9802e95ae8263dda3b3361e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2003.10.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15399192$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14697978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Atalay, F</creatorcontrib><creatorcontrib>Ozcay, N</creatorcontrib><creatorcontrib>Gundogdu, H</creatorcontrib><creatorcontrib>Orug, T</creatorcontrib><creatorcontrib>Gungor, A</creatorcontrib><creatorcontrib>Akoglu, M</creatorcontrib><title>Evaluation of the outcomes of short bowel syndrome and indications for intestinal transplantation</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Long-term parenteral nutrition (PN) and intestinal transplantation (IT) are life-saving therapies for patients with short bowel syndrome (SBS). However, indications and timing of these therapies are controversial. In this study we aimed to evaluate the indications for IT. Forty-two patients, each with <100 cm of small bowel, were divided into three groups according to the length of remnant: group I patients (n = 18): colon plus 50 to 100 cm of small bowel (SB); group II patients (n = 14): colon plus <50 cm of SB; and group III patients (n = 10): <50 cm of SB without colon. One-year mortality rates for groups I, II, and III were 50%, 72%, and 100%, respectively. All group I survivors developed intestinal adaptation, returning to regular oral feedings at 1 year. Interestingly, three of four surviving patients in group II developed adaptation and were fed an oral short bowel diet (SBD) at 1 year. None of the group III patients survived >1 year, dying due to multiorgan failure in the early postoperative period or from sepsis within 1 year. We conclude that patients with a very short bowel are candidates for IT when stable. If the colon is intact, however, regardless of small bowel remnant length, the patient should be given a chance to develop intestinal adaptation before making the decision for permanent PN or IT.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Intestines - transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Parenteral Nutrition, Total</subject><subject>Retrospective Studies</subject><subject>Short Bowel Syndrome - complications</subject><subject>Short Bowel Syndrome - surgery</subject><subject>Short Bowel Syndrome - therapy</subject><subject>Stomach, duodenum, intestine, rectum, anus</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Thromboembolism - surgery</subject><subject>Time Factors</subject><subject>Transplantation, Homologous</subject><subject>Treatment Outcome</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtP3DAUha0KVAbav1BZlegugx-JE7OrKLSVkNjA2rpxrjUeZWJqO6D593geKl12ZR2d71wfHUK-crbkjKur9TJHmNJzDBZxWArGZDGWjLcfyIJ3rayEEvKELBirecVl3ZyR85TWrGhRy4_kjNdKt7rtFgRuX2CcIfsw0eBoXiENc7Zhg2mn0yrETPvwiiNN22mIxaAwDdRPg7f7WKIuxKIzpuwnGOmh3AhT3vufyKmDMeHn43tBnu5uH29-VfcPP3_ffL-vbM1UrtAqBYjoGtH1DbAWG6mgbzkH0M4JqZtG1UI43TGBugHshJLDALKXUnGUF-Tb4W7Z5c9cypiNTxbHUgTDnEzL605I3hbw-gDaGFKK6Mxz9BuIW8OZ2Q1s1ubfgc1u4J3H9uEvx1_mflO8v9HjogW4PAKQLIyuHLI-vXON1JprUbgfBw7LJi8eo0nW42Rx8BFtNkPw_9PnDdcQotc</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Atalay, F</creator><creator>Ozcay, N</creator><creator>Gundogdu, H</creator><creator>Orug, T</creator><creator>Gungor, A</creator><creator>Akoglu, M</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>Evaluation of the outcomes of short bowel syndrome and indications for intestinal transplantation</title><author>Atalay, F ; Ozcay, N ; Gundogdu, H ; Orug, T ; Gungor, A ; Akoglu, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-ec66aeeef528b5a07e536ab711aa9ff239556422f9802e95ae8263dda3b3361e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Intestines - transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Parenteral Nutrition, Total</topic><topic>Retrospective Studies</topic><topic>Short Bowel Syndrome - complications</topic><topic>Short Bowel Syndrome - surgery</topic><topic>Short Bowel Syndrome - therapy</topic><topic>Stomach, duodenum, intestine, rectum, anus</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Thromboembolism - surgery</topic><topic>Time Factors</topic><topic>Transplantation, Homologous</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Atalay, F</creatorcontrib><creatorcontrib>Ozcay, N</creatorcontrib><creatorcontrib>Gundogdu, H</creatorcontrib><creatorcontrib>Orug, T</creatorcontrib><creatorcontrib>Gungor, A</creatorcontrib><creatorcontrib>Akoglu, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Atalay, F</au><au>Ozcay, N</au><au>Gundogdu, H</au><au>Orug, T</au><au>Gungor, A</au><au>Akoglu, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the outcomes of short bowel syndrome and indications for intestinal transplantation</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>35</volume><issue>8</issue><spage>3054</spage><epage>3056</epage><pages>3054-3056</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Long-term parenteral nutrition (PN) and intestinal transplantation (IT) are life-saving therapies for patients with short bowel syndrome (SBS). However, indications and timing of these therapies are controversial. In this study we aimed to evaluate the indications for IT. Forty-two patients, each with <100 cm of small bowel, were divided into three groups according to the length of remnant: group I patients (n = 18): colon plus 50 to 100 cm of small bowel (SB); group II patients (n = 14): colon plus <50 cm of SB; and group III patients (n = 10): <50 cm of SB without colon. One-year mortality rates for groups I, II, and III were 50%, 72%, and 100%, respectively. All group I survivors developed intestinal adaptation, returning to regular oral feedings at 1 year. Interestingly, three of four surviving patients in group II developed adaptation and were fed an oral short bowel diet (SBD) at 1 year. None of the group III patients survived >1 year, dying due to multiorgan failure in the early postoperative period or from sepsis within 1 year. We conclude that patients with a very short bowel are candidates for IT when stable. If the colon is intact, however, regardless of small bowel remnant length, the patient should be given a chance to develop intestinal adaptation before making the decision for permanent PN or IT.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>14697978</pmid><doi>10.1016/j.transproceed.2003.10.017</doi><tpages>3</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Female Gastroenterology. Liver. Pancreas. Abdomen Humans Intestines - transplantation Male Medical sciences Middle Aged Other diseases. Semiology Parenteral Nutrition, Total Retrospective Studies Short Bowel Syndrome - complications Short Bowel Syndrome - surgery Short Bowel Syndrome - therapy Stomach, duodenum, intestine, rectum, anus Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Thromboembolism - surgery Time Factors Transplantation, Homologous Treatment Outcome |
| title | Evaluation of the outcomes of short bowel syndrome and indications for intestinal transplantation |
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