Huntingtin Is Present in the Nucleus, Interacts with the Transcriptional Corepressor C-terminal Binding Protein, and Represses Transcription

Huntingtin is a protein of unknown function that contains a polyglutamine tract, which is expanded in patients with Huntington's disease (HD). We investigated the localization and a potential function for huntingtin in the nucleus. In human fibroblasts from normal and HD patients, huntingtin lo...

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Veröffentlicht in:	The Journal of biological chemistry 2002-03, Vol.277 (9), p.7466-7476
Hauptverfasser:	Kegel, Kimberly B., Meloni, Alison R., Yi, Yong, Kim, Yun J., Doyle, Erin, Cuiffo, Benjamin G., Sapp, Ellen, Wang, Yumei, Qin, Zheng-Hong, Chen, J. Don, Nevins, Joseph R., Aronin, Neil, DiFiglia, Marian
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Oxidoreductases Animals Blotting, Western Brain - metabolism C-terminal-binding protein Cell Line Cell Nucleus - metabolism COS Cells DNA-Binding Proteins - metabolism Epitopes Fibroblasts - metabolism Humans Huntingtin Protein Huntington Disease - metabolism Immunohistochemistry Mice Microscopy, Confocal Models, Genetic Mutation Nerve Tissue Proteins - biosynthesis Nuclear Proteins - biosynthesis Peptides - metabolism Phosphoproteins - metabolism Precipitin Tests Protein Binding Protein Structure, Tertiary RNA - metabolism Sodium Oxybate - pharmacology Transcription, Genetic Transfection
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