Hepatocyte growth factor as a potential predictor of the presence of atherosclerotic aorto-iliac artery disease
Background Hepatocyte growth factor (HGF), a member of the endothelial-specific growth factors with the greatest mitogenic activity, may play a role in the protection and/or repair of vascular endothelial cells injured by atherosclerosis. As a result, plasma HGF concentration may increase in respons...
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| Veröffentlicht in: | The American heart journal 2002-02, Vol.143 (2), p.272-276 |
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| creator | Tateishi, Jun Waku, Shinzou Masutani, Motomaru Ohyanagi, Mitsumasa Iwasaki, Tadaaki |
| description | Background Hepatocyte growth factor (HGF), a member of the endothelial-specific growth factors with the greatest mitogenic activity, may play a role in the protection and/or repair of vascular endothelial cells injured by atherosclerosis. As a result, plasma HGF concentration may increase in response to endothelial cell damage. To test this hypothesis, we measured plasma concentrations of HGF in patients with or without aorto-iliac artery atherosclerotic disease. Methods One hundred ten consecutive patients who underwent coronary angiography were enrolled in this study. Abdominal aortography was performed after coronary arteriography to determine whether aorto-iliac artery atherosclerotic disease was present. Peripheral venous blood samples were obtained to measure the plasma HGF concentration. Results Aortography revealed aorto-iliac atherosclerotic disease in 35 patients (32%). The plasma HGF concentration was significantly higher in patients with arteriosclerotic lesions (0.35 ± 0.11 ng/mL) than in patients without atherosclerotic lesions (0.27 ± 0.09 ng/mL, P =.0002). On the basis of multiple logistic regression analysis of the relationships between coronary risk factors, age, sex, severity of coronary artery disease, plasma HGF concentration, and the presence of arteriosclerotic lesions, plasma HGF concentration (P =.0005) and age (P =.035) were found to predict independently the presence of aorto-iliac arteriosclerosis. Conclusion Plasma HGF concentration can be used to predict the presence of arteriosclerotic lesions in the region from the abdominal aorta to the femoral arteries. (Am Heart J 2002;143:272-6.) |
| doi_str_mv | 10.1067/mhj.2002.120151 |
| format | Article |
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As a result, plasma HGF concentration may increase in response to endothelial cell damage. To test this hypothesis, we measured plasma concentrations of HGF in patients with or without aorto-iliac artery atherosclerotic disease. Methods One hundred ten consecutive patients who underwent coronary angiography were enrolled in this study. Abdominal aortography was performed after coronary arteriography to determine whether aorto-iliac artery atherosclerotic disease was present. Peripheral venous blood samples were obtained to measure the plasma HGF concentration. Results Aortography revealed aorto-iliac atherosclerotic disease in 35 patients (32%). The plasma HGF concentration was significantly higher in patients with arteriosclerotic lesions (0.35 ± 0.11 ng/mL) than in patients without atherosclerotic lesions (0.27 ± 0.09 ng/mL, P =.0002). On the basis of multiple logistic regression analysis of the relationships between coronary risk factors, age, sex, severity of coronary artery disease, plasma HGF concentration, and the presence of arteriosclerotic lesions, plasma HGF concentration (P =.0005) and age (P =.035) were found to predict independently the presence of aorto-iliac arteriosclerosis. Conclusion Plasma HGF concentration can be used to predict the presence of arteriosclerotic lesions in the region from the abdominal aorta to the femoral arteries. (Am Heart J 2002;143:272-6.)</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1067/mhj.2002.120151</identifier><identifier>PMID: 11835030</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Abdomen ; Adult ; Age ; Aged ; Aged, 80 and over ; Aortic Diseases - blood ; Aortic Diseases - diagnostic imaging ; Arteriosclerosis - blood ; Arteriosclerosis - diagnostic imaging ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; Blood pressure ; Body mass index ; Cardiology. Vascular system ; Cardiovascular disease ; Coronary vessels ; Endothelium ; Female ; Heart attacks ; Hepatocyte Growth Factor - blood ; Humans ; Iliac Artery - diagnostic imaging ; Logistics ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - blood ; Plasma ; Radiography ; Regression analysis ; Smooth muscle</subject><ispartof>The American heart journal, 2002-02, Vol.143 (2), p.272-276</ispartof><rights>2002 Mosby, Inc.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Elsevier Limited Feb 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-121e4b2aa4866f7f791de7bd81408a554e902ba447727aa626b871317892435e3</citedby><cites>FETCH-LOGICAL-c401t-121e4b2aa4866f7f791de7bd81408a554e902ba447727aa626b871317892435e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1504534101?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13485782$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11835030$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tateishi, Jun</creatorcontrib><creatorcontrib>Waku, Shinzou</creatorcontrib><creatorcontrib>Masutani, Motomaru</creatorcontrib><creatorcontrib>Ohyanagi, Mitsumasa</creatorcontrib><creatorcontrib>Iwasaki, Tadaaki</creatorcontrib><title>Hepatocyte growth factor as a potential predictor of the presence of atherosclerotic aorto-iliac artery disease</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>Background Hepatocyte growth factor (HGF), a member of the endothelial-specific growth factors with the greatest mitogenic activity, may play a role in the protection and/or repair of vascular endothelial cells injured by atherosclerosis. As a result, plasma HGF concentration may increase in response to endothelial cell damage. To test this hypothesis, we measured plasma concentrations of HGF in patients with or without aorto-iliac artery atherosclerotic disease. Methods One hundred ten consecutive patients who underwent coronary angiography were enrolled in this study. Abdominal aortography was performed after coronary arteriography to determine whether aorto-iliac artery atherosclerotic disease was present. Peripheral venous blood samples were obtained to measure the plasma HGF concentration. Results Aortography revealed aorto-iliac atherosclerotic disease in 35 patients (32%). The plasma HGF concentration was significantly higher in patients with arteriosclerotic lesions (0.35 ± 0.11 ng/mL) than in patients without atherosclerotic lesions (0.27 ± 0.09 ng/mL, P =.0002). On the basis of multiple logistic regression analysis of the relationships between coronary risk factors, age, sex, severity of coronary artery disease, plasma HGF concentration, and the presence of arteriosclerotic lesions, plasma HGF concentration (P =.0005) and age (P =.035) were found to predict independently the presence of aorto-iliac arteriosclerosis. Conclusion Plasma HGF concentration can be used to predict the presence of arteriosclerotic lesions in the region from the abdominal aorta to the femoral arteries. (Am Heart J 2002;143:272-6.)</description><subject>Abdomen</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aortic Diseases - blood</subject><subject>Aortic Diseases - diagnostic imaging</subject><subject>Arteriosclerosis - blood</subject><subject>Arteriosclerosis - diagnostic imaging</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood and lymphatic vessels</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Coronary vessels</subject><subject>Endothelium</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Hepatocyte Growth Factor - blood</subject><subject>Humans</subject><subject>Iliac Artery - diagnostic imaging</subject><subject>Logistics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - blood</subject><subject>Plasma</subject><subject>Radiography</subject><subject>Regression analysis</subject><subject>Smooth muscle</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kdGL1DAQxoMo3t7ps29SEH3rXiZJm_RRDvWEA1_0OUzTqZul29Qkq-x_b-ouHBz4kmRmfjNMvo-xN8C3wFt9e9jtt4JzsQXBoYFnbAO803WrlXrONrxUaqO5vGLXKe1L2ArTvmRXAEY2XPINC_e0YA7ulKn6GcOfvKtGdDnEClOF1RIyzdnjVC2RBv-vEMYq72hNJJodrTGWRAzJTeXM3lUYYg61nzyWd8wUT9XgE2GiV-zFiFOi15f7hv34_On73X398O3L17uPD7VTHHINAkj1AlGZth31qDsYSPeDAcUNNo2ijoseldJaaMRWtL3RIEGbTijZkLxhH85zlxh-HSlle_DJ0TThTOGYrAZlBJdQwHdPwH04xrnsZqHhqpEK-ErdnilXvpkijXaJ_oDxZIHb1QlbnLCrE_bsROl4e5l77A80PPIX6Qvw_gJgcjiNEWfn0yMnlWm0EYXrzhwVuX57ijY5vwo_-Egu2yH4_y7xF64Co8Y</recordid><startdate>20020201</startdate><enddate>20020201</enddate><creator>Tateishi, Jun</creator><creator>Waku, Shinzou</creator><creator>Masutani, Motomaru</creator><creator>Ohyanagi, Mitsumasa</creator><creator>Iwasaki, Tadaaki</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20020201</creationdate><title>Hepatocyte growth factor as a potential predictor of the presence of atherosclerotic aorto-iliac artery disease</title><author>Tateishi, Jun ; Waku, Shinzou ; Masutani, Motomaru ; Ohyanagi, Mitsumasa ; Iwasaki, Tadaaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-121e4b2aa4866f7f791de7bd81408a554e902ba447727aa626b871317892435e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Abdomen</topic><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aortic Diseases - blood</topic><topic>Aortic Diseases - diagnostic imaging</topic><topic>Arteriosclerosis - blood</topic><topic>Arteriosclerosis - diagnostic imaging</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood and lymphatic vessels</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Coronary vessels</topic><topic>Endothelium</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Hepatocyte Growth Factor - blood</topic><topic>Humans</topic><topic>Iliac Artery - diagnostic imaging</topic><topic>Logistics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - blood</topic><topic>Plasma</topic><topic>Radiography</topic><topic>Regression analysis</topic><topic>Smooth muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tateishi, Jun</creatorcontrib><creatorcontrib>Waku, Shinzou</creatorcontrib><creatorcontrib>Masutani, Motomaru</creatorcontrib><creatorcontrib>Ohyanagi, Mitsumasa</creatorcontrib><creatorcontrib>Iwasaki, Tadaaki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tateishi, Jun</au><au>Waku, Shinzou</au><au>Masutani, Motomaru</au><au>Ohyanagi, Mitsumasa</au><au>Iwasaki, Tadaaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatocyte growth factor as a potential predictor of the presence of atherosclerotic aorto-iliac artery disease</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>2002-02-01</date><risdate>2002</risdate><volume>143</volume><issue>2</issue><spage>272</spage><epage>276</epage><pages>272-276</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract>Background Hepatocyte growth factor (HGF), a member of the endothelial-specific growth factors with the greatest mitogenic activity, may play a role in the protection and/or repair of vascular endothelial cells injured by atherosclerosis. As a result, plasma HGF concentration may increase in response to endothelial cell damage. To test this hypothesis, we measured plasma concentrations of HGF in patients with or without aorto-iliac artery atherosclerotic disease. Methods One hundred ten consecutive patients who underwent coronary angiography were enrolled in this study. Abdominal aortography was performed after coronary arteriography to determine whether aorto-iliac artery atherosclerotic disease was present. Peripheral venous blood samples were obtained to measure the plasma HGF concentration. Results Aortography revealed aorto-iliac atherosclerotic disease in 35 patients (32%). The plasma HGF concentration was significantly higher in patients with arteriosclerotic lesions (0.35 ± 0.11 ng/mL) than in patients without atherosclerotic lesions (0.27 ± 0.09 ng/mL, P =.0002). On the basis of multiple logistic regression analysis of the relationships between coronary risk factors, age, sex, severity of coronary artery disease, plasma HGF concentration, and the presence of arteriosclerotic lesions, plasma HGF concentration (P =.0005) and age (P =.035) were found to predict independently the presence of aorto-iliac arteriosclerosis. Conclusion Plasma HGF concentration can be used to predict the presence of arteriosclerotic lesions in the region from the abdominal aorta to the femoral arteries. (Am Heart J 2002;143:272-6.)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>11835030</pmid><doi>10.1067/mhj.2002.120151</doi><tpages>5</tpages></addata></record> |
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| subjects | Abdomen Adult Age Aged Aged, 80 and over Aortic Diseases - blood Aortic Diseases - diagnostic imaging Arteriosclerosis - blood Arteriosclerosis - diagnostic imaging Atherosclerosis (general aspects, experimental research) Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels Blood pressure Body mass index Cardiology. Vascular system Cardiovascular disease Coronary vessels Endothelium Female Heart attacks Hepatocyte Growth Factor - blood Humans Iliac Artery - diagnostic imaging Logistics Male Medical sciences Middle Aged Myocardial Infarction - blood Plasma Radiography Regression analysis Smooth muscle |
| title | Hepatocyte growth factor as a potential predictor of the presence of atherosclerotic aorto-iliac artery disease |
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