Prostaglandins as modulators of immunity
Prostaglandins are potent lipid molecules that affect key aspects of immunity. The original view of prostaglandins was that they were simply immunoinhibitory. This review focuses on recent findings concerning prostaglandin E 2 (PGE 2) and the PGD 2 metabolite 15-deoxy-Δ 12,14-PGJ 2, and their diverg...
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| Veröffentlicht in: | Trends in Immunology 2002-03, Vol.23 (3), p.144-150 |
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| creator | Harris, Sarah G Padilla, Josue Koumas, Laura Ray, Denise Phipps, Richard P |
| description | Prostaglandins are potent lipid molecules that affect key aspects of immunity. The original view of prostaglandins was that they were simply immunoinhibitory. This review focuses on recent findings concerning prostaglandin E
2 (PGE
2) and the PGD
2 metabolite 15-deoxy-Δ
12,14-PGJ
2, and their divergent roles in immune regulation. We will highlight how these two seminal prostaglandins regulate immunity and inflammation, and play an emerging role in cancer progression. Understanding the diverse activities of these prostaglandins is crucial for the development of new therapies aimed at immune modulation.
Lipid mediators known as prostaglandins are central mediators of inflammation and the regulation of immunity, and play a key role in inducing certain cancers. |
| doi_str_mv | 10.1016/S1471-4906(01)02154-8 |
| format | Article |
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2 (PGE
2) and the PGD
2 metabolite 15-deoxy-Δ
12,14-PGJ
2, and their divergent roles in immune regulation. We will highlight how these two seminal prostaglandins regulate immunity and inflammation, and play an emerging role in cancer progression. Understanding the diverse activities of these prostaglandins is crucial for the development of new therapies aimed at immune modulation.
Lipid mediators known as prostaglandins are central mediators of inflammation and the regulation of immunity, and play a key role in inducing certain cancers.</description><identifier>ISSN: 1471-4906</identifier><identifier>EISSN: 1471-4981</identifier><identifier>DOI: 10.1016/S1471-4906(01)02154-8</identifier><identifier>PMID: 11864843</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adjuvants, Immunologic - physiology ; Angiogenesis ; Animals ; Apoptosis ; Cancer ; Cell growth ; cytokines ; Dinoprostone - biosynthesis ; Dinoprostone - physiology ; Enzymes ; Humans ; Immune system ; inflammation ; Inflammation - immunology ; Kinases ; Ligands ; Lymphocytes ; Models, Immunological ; Models, Molecular ; Neoplasms - immunology ; PPAR-gamma ; Prostaglandin D2 - analogs & derivatives ; Prostaglandin D2 - physiology ; prostaglandin E2 ; Prostaglandin-Endoperoxide Synthases - metabolism ; prostaglandins ; Rodents ; Tumorigenesis</subject><ispartof>Trends in Immunology, 2002-03, Vol.23 (3), p.144-150</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>Copyright Elsevier Limited Mar 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-f6e0cd60319c83c45e22b6ca47aa7f0d01763b364a35b2ed3df9bef1a45d9f833</citedby><cites>FETCH-LOGICAL-c472t-f6e0cd60319c83c45e22b6ca47aa7f0d01763b364a35b2ed3df9bef1a45d9f833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1471-4906(01)02154-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>313,314,777,781,789,3537,27903,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11864843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harris, Sarah G</creatorcontrib><creatorcontrib>Padilla, Josue</creatorcontrib><creatorcontrib>Koumas, Laura</creatorcontrib><creatorcontrib>Ray, Denise</creatorcontrib><creatorcontrib>Phipps, Richard P</creatorcontrib><title>Prostaglandins as modulators of immunity</title><title>Trends in Immunology</title><addtitle>Trends Immunol</addtitle><description>Prostaglandins are potent lipid molecules that affect key aspects of immunity. The original view of prostaglandins was that they were simply immunoinhibitory. This review focuses on recent findings concerning prostaglandin E
2 (PGE
2) and the PGD
2 metabolite 15-deoxy-Δ
12,14-PGJ
2, and their divergent roles in immune regulation. We will highlight how these two seminal prostaglandins regulate immunity and inflammation, and play an emerging role in cancer progression. Understanding the diverse activities of these prostaglandins is crucial for the development of new therapies aimed at immune modulation.
Lipid mediators known as prostaglandins are central mediators of inflammation and the regulation of immunity, and play a key role in inducing certain cancers.</description><subject>Adjuvants, Immunologic - physiology</subject><subject>Angiogenesis</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>Cell growth</subject><subject>cytokines</subject><subject>Dinoprostone - biosynthesis</subject><subject>Dinoprostone - physiology</subject><subject>Enzymes</subject><subject>Humans</subject><subject>Immune system</subject><subject>inflammation</subject><subject>Inflammation - immunology</subject><subject>Kinases</subject><subject>Ligands</subject><subject>Lymphocytes</subject><subject>Models, Immunological</subject><subject>Models, Molecular</subject><subject>Neoplasms - immunology</subject><subject>PPAR-gamma</subject><subject>Prostaglandin D2 - analogs & derivatives</subject><subject>Prostaglandin D2 - physiology</subject><subject>prostaglandin E2</subject><subject>Prostaglandin-Endoperoxide Synthases - metabolism</subject><subject>prostaglandins</subject><subject>Rodents</subject><subject>Tumorigenesis</subject><issn>1471-4906</issn><issn>1471-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEQgIMotlZ_glIQpB5WM5tskj2JFF9QUFDPIZtkJWUfNdkV-u9N20XBi6cZhm9eH0KngK8AA7t-BcohoTlmMwyXOIWMJmIPjYeygP2fHLMROgphiTFknPNDNAIQjApKxmj24tvQqY9KNcY1YarCtG5NX6mu9WHallNX133juvUxOihVFezJECfo_f7ubf6YLJ4fnua3i0RTnnZJySzWhmECuRZE08ymacG0olwpXmKDgTNSEEYVyYrUGmLKvLAlKJqZvBSETNDFbu7Kt5-9DZ2sXdC2igfatg-SAxUgUv4vCILgVKR5BM__gMu29018QkKGWR6lUBqpbEfpKCR4W8qVd7XyawlYbozLrXG50SkxyK1xKWLf2TC9L2prfrsGxRG42QE2Wvty1sugnW20Nc5b3UnTun9WfAOWeI6B</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Harris, Sarah G</creator><creator>Padilla, Josue</creator><creator>Koumas, Laura</creator><creator>Ray, Denise</creator><creator>Phipps, Richard P</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Prostaglandins as modulators of immunity</title><author>Harris, Sarah G ; Padilla, Josue ; Koumas, Laura ; Ray, Denise ; Phipps, Richard P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-f6e0cd60319c83c45e22b6ca47aa7f0d01763b364a35b2ed3df9bef1a45d9f833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adjuvants, Immunologic - physiology</topic><topic>Angiogenesis</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Cancer</topic><topic>Cell growth</topic><topic>cytokines</topic><topic>Dinoprostone - biosynthesis</topic><topic>Dinoprostone - physiology</topic><topic>Enzymes</topic><topic>Humans</topic><topic>Immune system</topic><topic>inflammation</topic><topic>Inflammation - immunology</topic><topic>Kinases</topic><topic>Ligands</topic><topic>Lymphocytes</topic><topic>Models, Immunological</topic><topic>Models, Molecular</topic><topic>Neoplasms - immunology</topic><topic>PPAR-gamma</topic><topic>Prostaglandin D2 - analogs & derivatives</topic><topic>Prostaglandin D2 - physiology</topic><topic>prostaglandin E2</topic><topic>Prostaglandin-Endoperoxide Synthases - metabolism</topic><topic>prostaglandins</topic><topic>Rodents</topic><topic>Tumorigenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harris, Sarah G</creatorcontrib><creatorcontrib>Padilla, Josue</creatorcontrib><creatorcontrib>Koumas, Laura</creatorcontrib><creatorcontrib>Ray, Denise</creatorcontrib><creatorcontrib>Phipps, Richard P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harris, Sarah G</au><au>Padilla, Josue</au><au>Koumas, Laura</au><au>Ray, Denise</au><au>Phipps, Richard P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prostaglandins as modulators of immunity</atitle><jtitle>Trends in Immunology</jtitle><addtitle>Trends Immunol</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>23</volume><issue>3</issue><spage>144</spage><epage>150</epage><pages>144-150</pages><issn>1471-4906</issn><eissn>1471-4981</eissn><abstract>Prostaglandins are potent lipid molecules that affect key aspects of immunity. The original view of prostaglandins was that they were simply immunoinhibitory. This review focuses on recent findings concerning prostaglandin E
2 (PGE
2) and the PGD
2 metabolite 15-deoxy-Δ
12,14-PGJ
2, and their divergent roles in immune regulation. We will highlight how these two seminal prostaglandins regulate immunity and inflammation, and play an emerging role in cancer progression. Understanding the diverse activities of these prostaglandins is crucial for the development of new therapies aimed at immune modulation.
Lipid mediators known as prostaglandins are central mediators of inflammation and the regulation of immunity, and play a key role in inducing certain cancers.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>11864843</pmid><doi>10.1016/S1471-4906(01)02154-8</doi><tpages>7</tpages></addata></record> |
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| ispartof | Trends in Immunology, 2002-03, Vol.23 (3), p.144-150 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adjuvants, Immunologic - physiology Angiogenesis Animals Apoptosis Cancer Cell growth cytokines Dinoprostone - biosynthesis Dinoprostone - physiology Enzymes Humans Immune system inflammation Inflammation - immunology Kinases Ligands Lymphocytes Models, Immunological Models, Molecular Neoplasms - immunology PPAR-gamma Prostaglandin D2 - analogs & derivatives Prostaglandin D2 - physiology prostaglandin E2 Prostaglandin-Endoperoxide Synthases - metabolism prostaglandins Rodents Tumorigenesis |
| title | Prostaglandins as modulators of immunity |
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