Persistent high plasma levels of interleukins 18 and 4 in children with recurrent infections of the upper respiratory tract
The aim of this study was to examine whether children with recurrent infections of the upper respiratory tract might have alterations in the systemic immune response to viral infections as compared with healthy control children. We quantitated plasma levels of interferon-γ, interleukin-12, interleuk...
Gespeichert in:
| Veröffentlicht in: | Transplantation proceedings 2003-12, Vol.35 (8), p.2911-2915 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2915 |
|---|---|
| container_issue | 8 |
| container_start_page | 2911 |
| container_title | Transplantation proceedings |
| container_volume | 35 |
| creator | Volti, G.Li Malaponte, G Bevelacqua, V Messina, A Bianca, S Mazzarino, M.C Li Volti, S |
| description | The aim of this study was to examine whether children with recurrent infections of the upper respiratory tract might have alterations in the systemic immune response to viral infections as compared with healthy control children. We quantitated plasma levels of interferon-γ, interleukin-12, interleukin-18, interleukin-4, lymphocyte subpopulations, serum immunoglobulins, and subclasses of immunoglobulin G in 30 children under the age of 6 years with recurrent infections of the upper respiratory tract, both during the acute phase of the infection and 4 weeks later, when clinical symptoms had resolved, as well as in 20 normal controls. We found elevated levels of immunoglobulin G primarily due to increased levels of immunoglobulin G
1. Moreover, significantly higher levels of interleukin-18 and interleukin-4 were noted during the acute phase of infection among children with an increased incidence of respiratory infections as compared with the controls (
P = .022 and
P = .0001, respectively), while plasma levels of interferon-γ and interleukin-12 were significantly lower (
P = .034 and
P = .0001, respectively) than in controls. We suggest that an imbalance between T-cell helper type-1 and T-cell helper type-2 immune responses might be responsible for the perpetuation of recurrent infections of the upper respiratory tract. |
| doi_str_mv | 10.1016/j.transproceed.2003.10.024 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71481569</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0041134503011199</els_id><sourcerecordid>71481569</sourcerecordid><originalsourceid>FETCH-LOGICAL-c406t-47e243fe17843666064a8e5eecb00c6d3da5fe6d7ace0cb66ab4693bf88d2de93</originalsourceid><addsrcrecordid>eNqNkUuP1SAUgInRONfRv2CIie56hUJp687M-Eom0YWuCYVTy5VLK4eOmfjnpd4bdemKwPnO64OQZ5ztOePq5WGfk4m4pNkCuH3NmCiBPavlPbLjXSuqWtXiPtkxJnnFhWwuyCPEAyv3WoqH5IJL1be9UDvy8xMk9JghZjr5rxNdgsGjoQFuISCdR-pjhhRg_eYjUt5REx2V5ZXayQeXINIfPk80gV1T2sr4OILNfo6_0_MEdF0WSIXAxSeT53RHywI2PyYPRhMQnpzPS_Ll7ZvPV--rm4_vPly9vqmsZCpXsoUy9Qi87aRQSjElTQcNgB0Ys8oJZ5oRlGuNBWYHpcxQ1hPD2HWudtCLS_LiVLcY-74CZn30aCEEE2FeUbdcdrxRG_jqBNo0IyYY9ZL80aQ7zZne1OuD_le93tRvsaK-JD89d1mHY4n9ST27LsDzM2DQmjCWQtbjX64Rfc8bVrjrE1c-AG49JI3WQ7TgfJGctZv9_8zzCwGVrAo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71481569</pqid></control><display><type>article</type><title>Persistent high plasma levels of interleukins 18 and 4 in children with recurrent infections of the upper respiratory tract</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Volti, G.Li ; Malaponte, G ; Bevelacqua, V ; Messina, A ; Bianca, S ; Mazzarino, M.C ; Li Volti, S</creator><creatorcontrib>Volti, G.Li ; Malaponte, G ; Bevelacqua, V ; Messina, A ; Bianca, S ; Mazzarino, M.C ; Li Volti, S</creatorcontrib><description>The aim of this study was to examine whether children with recurrent infections of the upper respiratory tract might have alterations in the systemic immune response to viral infections as compared with healthy control children. We quantitated plasma levels of interferon-γ, interleukin-12, interleukin-18, interleukin-4, lymphocyte subpopulations, serum immunoglobulins, and subclasses of immunoglobulin G in 30 children under the age of 6 years with recurrent infections of the upper respiratory tract, both during the acute phase of the infection and 4 weeks later, when clinical symptoms had resolved, as well as in 20 normal controls. We found elevated levels of immunoglobulin G primarily due to increased levels of immunoglobulin G
1. Moreover, significantly higher levels of interleukin-18 and interleukin-4 were noted during the acute phase of infection among children with an increased incidence of respiratory infections as compared with the controls (
P = .022 and
P = .0001, respectively), while plasma levels of interferon-γ and interleukin-12 were significantly lower (
P = .034 and
P = .0001, respectively) than in controls. We suggest that an imbalance between T-cell helper type-1 and T-cell helper type-2 immune responses might be responsible for the perpetuation of recurrent infections of the upper respiratory tract.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2003.10.024</identifier><identifier>PMID: 14697936</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Child, Preschool ; Female ; Human viral diseases ; Humans ; Immunoglobulin G - blood ; Immunoglobulin G - classification ; Immunoglobulin Idiotypes - immunology ; Immunoglobulins - blood ; Infectious diseases ; Interleukin-18 - blood ; Interleukin-4 - blood ; Lymphocyte Subsets - immunology ; Male ; Medical sciences ; Recurrence ; Reference Values ; Respiratory Tract Infections - blood ; Respiratory Tract Infections - immunology ; Viral diseases ; Viral diseases of the respiratory system and ent viral diseases</subject><ispartof>Transplantation proceedings, 2003-12, Vol.35 (8), p.2911-2915</ispartof><rights>2003 Elsevier Science Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-47e243fe17843666064a8e5eecb00c6d3da5fe6d7ace0cb66ab4693bf88d2de93</citedby><cites>FETCH-LOGICAL-c406t-47e243fe17843666064a8e5eecb00c6d3da5fe6d7ace0cb66ab4693bf88d2de93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2003.10.024$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15399150$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14697936$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Volti, G.Li</creatorcontrib><creatorcontrib>Malaponte, G</creatorcontrib><creatorcontrib>Bevelacqua, V</creatorcontrib><creatorcontrib>Messina, A</creatorcontrib><creatorcontrib>Bianca, S</creatorcontrib><creatorcontrib>Mazzarino, M.C</creatorcontrib><creatorcontrib>Li Volti, S</creatorcontrib><title>Persistent high plasma levels of interleukins 18 and 4 in children with recurrent infections of the upper respiratory tract</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>The aim of this study was to examine whether children with recurrent infections of the upper respiratory tract might have alterations in the systemic immune response to viral infections as compared with healthy control children. We quantitated plasma levels of interferon-γ, interleukin-12, interleukin-18, interleukin-4, lymphocyte subpopulations, serum immunoglobulins, and subclasses of immunoglobulin G in 30 children under the age of 6 years with recurrent infections of the upper respiratory tract, both during the acute phase of the infection and 4 weeks later, when clinical symptoms had resolved, as well as in 20 normal controls. We found elevated levels of immunoglobulin G primarily due to increased levels of immunoglobulin G
1. Moreover, significantly higher levels of interleukin-18 and interleukin-4 were noted during the acute phase of infection among children with an increased incidence of respiratory infections as compared with the controls (
P = .022 and
P = .0001, respectively), while plasma levels of interferon-γ and interleukin-12 were significantly lower (
P = .034 and
P = .0001, respectively) than in controls. We suggest that an imbalance between T-cell helper type-1 and T-cell helper type-2 immune responses might be responsible for the perpetuation of recurrent infections of the upper respiratory tract.</description><subject>Biological and medical sciences</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G - classification</subject><subject>Immunoglobulin Idiotypes - immunology</subject><subject>Immunoglobulins - blood</subject><subject>Infectious diseases</subject><subject>Interleukin-18 - blood</subject><subject>Interleukin-4 - blood</subject><subject>Lymphocyte Subsets - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Recurrence</subject><subject>Reference Values</subject><subject>Respiratory Tract Infections - blood</subject><subject>Respiratory Tract Infections - immunology</subject><subject>Viral diseases</subject><subject>Viral diseases of the respiratory system and ent viral diseases</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUuP1SAUgInRONfRv2CIie56hUJp687M-Eom0YWuCYVTy5VLK4eOmfjnpd4bdemKwPnO64OQZ5ztOePq5WGfk4m4pNkCuH3NmCiBPavlPbLjXSuqWtXiPtkxJnnFhWwuyCPEAyv3WoqH5IJL1be9UDvy8xMk9JghZjr5rxNdgsGjoQFuISCdR-pjhhRg_eYjUt5REx2V5ZXayQeXINIfPk80gV1T2sr4OILNfo6_0_MEdF0WSIXAxSeT53RHywI2PyYPRhMQnpzPS_Ll7ZvPV--rm4_vPly9vqmsZCpXsoUy9Qi87aRQSjElTQcNgB0Ys8oJZ5oRlGuNBWYHpcxQ1hPD2HWudtCLS_LiVLcY-74CZn30aCEEE2FeUbdcdrxRG_jqBNo0IyYY9ZL80aQ7zZne1OuD_le93tRvsaK-JD89d1mHY4n9ST27LsDzM2DQmjCWQtbjX64Rfc8bVrjrE1c-AG49JI3WQ7TgfJGctZv9_8zzCwGVrAo</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Volti, G.Li</creator><creator>Malaponte, G</creator><creator>Bevelacqua, V</creator><creator>Messina, A</creator><creator>Bianca, S</creator><creator>Mazzarino, M.C</creator><creator>Li Volti, S</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>Persistent high plasma levels of interleukins 18 and 4 in children with recurrent infections of the upper respiratory tract</title><author>Volti, G.Li ; Malaponte, G ; Bevelacqua, V ; Messina, A ; Bianca, S ; Mazzarino, M.C ; Li Volti, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-47e243fe17843666064a8e5eecb00c6d3da5fe6d7ace0cb66ab4693bf88d2de93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin G - classification</topic><topic>Immunoglobulin Idiotypes - immunology</topic><topic>Immunoglobulins - blood</topic><topic>Infectious diseases</topic><topic>Interleukin-18 - blood</topic><topic>Interleukin-4 - blood</topic><topic>Lymphocyte Subsets - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Recurrence</topic><topic>Reference Values</topic><topic>Respiratory Tract Infections - blood</topic><topic>Respiratory Tract Infections - immunology</topic><topic>Viral diseases</topic><topic>Viral diseases of the respiratory system and ent viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Volti, G.Li</creatorcontrib><creatorcontrib>Malaponte, G</creatorcontrib><creatorcontrib>Bevelacqua, V</creatorcontrib><creatorcontrib>Messina, A</creatorcontrib><creatorcontrib>Bianca, S</creatorcontrib><creatorcontrib>Mazzarino, M.C</creatorcontrib><creatorcontrib>Li Volti, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Volti, G.Li</au><au>Malaponte, G</au><au>Bevelacqua, V</au><au>Messina, A</au><au>Bianca, S</au><au>Mazzarino, M.C</au><au>Li Volti, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistent high plasma levels of interleukins 18 and 4 in children with recurrent infections of the upper respiratory tract</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>35</volume><issue>8</issue><spage>2911</spage><epage>2915</epage><pages>2911-2915</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>The aim of this study was to examine whether children with recurrent infections of the upper respiratory tract might have alterations in the systemic immune response to viral infections as compared with healthy control children. We quantitated plasma levels of interferon-γ, interleukin-12, interleukin-18, interleukin-4, lymphocyte subpopulations, serum immunoglobulins, and subclasses of immunoglobulin G in 30 children under the age of 6 years with recurrent infections of the upper respiratory tract, both during the acute phase of the infection and 4 weeks later, when clinical symptoms had resolved, as well as in 20 normal controls. We found elevated levels of immunoglobulin G primarily due to increased levels of immunoglobulin G
1. Moreover, significantly higher levels of interleukin-18 and interleukin-4 were noted during the acute phase of infection among children with an increased incidence of respiratory infections as compared with the controls (
P = .022 and
P = .0001, respectively), while plasma levels of interferon-γ and interleukin-12 were significantly lower (
P = .034 and
P = .0001, respectively) than in controls. We suggest that an imbalance between T-cell helper type-1 and T-cell helper type-2 immune responses might be responsible for the perpetuation of recurrent infections of the upper respiratory tract.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>14697936</pmid><doi>10.1016/j.transproceed.2003.10.024</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1345 |
| ispartof | Transplantation proceedings, 2003-12, Vol.35 (8), p.2911-2915 |
| issn | 0041-1345 1873-2623 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71481569 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Biological and medical sciences Child, Preschool Female Human viral diseases Humans Immunoglobulin G - blood Immunoglobulin G - classification Immunoglobulin Idiotypes - immunology Immunoglobulins - blood Infectious diseases Interleukin-18 - blood Interleukin-4 - blood Lymphocyte Subsets - immunology Male Medical sciences Recurrence Reference Values Respiratory Tract Infections - blood Respiratory Tract Infections - immunology Viral diseases Viral diseases of the respiratory system and ent viral diseases |
| title | Persistent high plasma levels of interleukins 18 and 4 in children with recurrent infections of the upper respiratory tract |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T18%3A58%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Persistent%20high%20plasma%20levels%20of%20interleukins%2018%20and%204%20in%20children%20with%20recurrent%20infections%20of%20the%20upper%20respiratory%20tract&rft.jtitle=Transplantation%20proceedings&rft.au=Volti,%20G.Li&rft.date=2003-12-01&rft.volume=35&rft.issue=8&rft.spage=2911&rft.epage=2915&rft.pages=2911-2915&rft.issn=0041-1345&rft.eissn=1873-2623&rft.coden=TRPPA8&rft_id=info:doi/10.1016/j.transproceed.2003.10.024&rft_dat=%3Cproquest_cross%3E71481569%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71481569&rft_id=info:pmid/14697936&rft_els_id=S0041134503011199&rfr_iscdi=true |