CHLOROQUINE-RESISTANT PLASMODIUM VIVAX MALARIA IN PERU
Reports from several sites in South America suggest the presence of isolated cases of chloroquine-resistant Plasmodium vivax malaria. To investigate the possibility of chloroquine-resistant P. vivax in Peru, we conducted 28-day in vivo drug efficacy trials at three sites in the Amazon region and one...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2003-11, Vol.69 (5), p.548-552 |
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| creator | RUEBUSH, TRENTON K., II ZEGARRA, JORGE CAIRO, JAVIER ANDERSEN, ELLEN M GREEN, MICHAEL PILLAI, DYLAN R MARQUINO, WILMER HUILCA, MARIA AREVALO, ERNESTO GARCIA, CORALITH SOLARY, LELY KAIN, KEVIN C |
| description | Reports from several sites in South America suggest the presence of isolated cases of chloroquine-resistant Plasmodium vivax malaria. To investigate the possibility of chloroquine-resistant P. vivax in Peru, we conducted 28-day in vivo drug efficacy trials at three sites in the Amazon region and one site on the northern Pacific Coast between 1998 and 2001. A total of 242 patients between the ages of 2 and 60 years were enrolled (177 from the Amazon region and 65 from the northern coast). All subjects received directly observed therapy with chloroquine, 25 mg/kg, over a three-day period. On enrollment, 49% had a documented fever and 96% had a history of fever; their geometric mean parasite density was 5,129 parasites/microL. A total of 212 (88%) of the 242 subjects completed their 28-day follow-up. Four of the 177 patients from the Amazon region had a recurrence of P. vivax parasitemia on days 21 and 28 after treatment was initiated. Two of these patients had chloroquine-resistant infections, based on polymerase chain reaction-single-stranded conformational polymorphism genotyping and chloroquine-desethylchloroquine blood levels, which were > or = 97 ng/mL at the time of the reappearance of parasitemia. None of the subjects studied on the northern Pacific Coast had recurrent parasitemia. |
| doi_str_mv | 10.4269/ajtmh.2003.69.548 |
| format | Article |
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To investigate the possibility of chloroquine-resistant P. vivax in Peru, we conducted 28-day in vivo drug efficacy trials at three sites in the Amazon region and one site on the northern Pacific Coast between 1998 and 2001. A total of 242 patients between the ages of 2 and 60 years were enrolled (177 from the Amazon region and 65 from the northern coast). All subjects received directly observed therapy with chloroquine, 25 mg/kg, over a three-day period. On enrollment, 49% had a documented fever and 96% had a history of fever; their geometric mean parasite density was 5,129 parasites/microL. A total of 212 (88%) of the 242 subjects completed their 28-day follow-up. Four of the 177 patients from the Amazon region had a recurrence of P. vivax parasitemia on days 21 and 28 after treatment was initiated. Two of these patients had chloroquine-resistant infections, based on polymerase chain reaction-single-stranded conformational polymorphism genotyping and chloroquine-desethylchloroquine blood levels, which were > or = 97 ng/mL at the time of the reappearance of parasitemia. 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To investigate the possibility of chloroquine-resistant P. vivax in Peru, we conducted 28-day in vivo drug efficacy trials at three sites in the Amazon region and one site on the northern Pacific Coast between 1998 and 2001. A total of 242 patients between the ages of 2 and 60 years were enrolled (177 from the Amazon region and 65 from the northern coast). All subjects received directly observed therapy with chloroquine, 25 mg/kg, over a three-day period. On enrollment, 49% had a documented fever and 96% had a history of fever; their geometric mean parasite density was 5,129 parasites/microL. A total of 212 (88%) of the 242 subjects completed their 28-day follow-up. Four of the 177 patients from the Amazon region had a recurrence of P. vivax parasitemia on days 21 and 28 after treatment was initiated. Two of these patients had chloroquine-resistant infections, based on polymerase chain reaction-single-stranded conformational polymorphism genotyping and chloroquine-desethylchloroquine blood levels, which were > or = 97 ng/mL at the time of the reappearance of parasitemia. None of the subjects studied on the northern Pacific Coast had recurrent parasitemia.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Animals</subject><subject>Antimalarials - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chloroquine - pharmacology</subject><subject>DNA, Protozoan - analysis</subject><subject>Drug Resistance</subject><subject>Female</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Malaria</subject><subject>Malaria, Vivax - epidemiology</subject><subject>Malaria, Vivax - parasitology</subject><subject>Malaria, Vivax - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>parasitemia</subject><subject>Parasitic diseases</subject><subject>Peru - epidemiology</subject><subject>Plasmodium vivax</subject><subject>Plasmodium vivax - drug effects</subject><subject>Plasmodium vivax - genetics</subject><subject>Polymerase Chain Reaction</subject><subject>Protozoal diseases</subject><subject>Recurrence</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwkAUhSdGI4j-ADemG90V53am086yQZQmhWJ5xN1kmE6lpAXsQBr_veWRsHR1c5PvnJN8CD0C7lKH8Ve52pXLroMx6TLedal_hdpAPWYDo-41amOMHZsz4rXQnTErjMF3AG5RCyjjLua0jVhvEMVJ_DkLR3076U_CyTQYTa1xFEyG8Vs4G1rzcB58WcMgCpIwsMKRNe4ns3t0k8nC6Ifz7aDZe3_aG9hR_BH2gshWlJCdLQlVHCBLdaZVylOutdQex8wnjHuum6Vy4QP2fb1gGFPp6MxZ-CTlimpPpZh00Mupd1ttfvba7ESZG6WLQq71Zm-EB9QH6vB_QeAOY81mA8IJVNXGmEpnYlvlpax-BWBxsCqOVsXBqmi-xmqTeTqX7xelTi-Js8YGeD4D0ihZZJVcq9xcOJcQoBgu3DL_XtZ5pYUpZVE0tSDquj7MHQf_AETkiL0</recordid><startdate>20031101</startdate><enddate>20031101</enddate><creator>RUEBUSH, TRENTON K., II</creator><creator>ZEGARRA, JORGE</creator><creator>CAIRO, JAVIER</creator><creator>ANDERSEN, ELLEN M</creator><creator>GREEN, MICHAEL</creator><creator>PILLAI, DYLAN R</creator><creator>MARQUINO, WILMER</creator><creator>HUILCA, MARIA</creator><creator>AREVALO, ERNESTO</creator><creator>GARCIA, CORALITH</creator><creator>SOLARY, LELY</creator><creator>KAIN, KEVIN C</creator><general>ASTMH</general><general>Allen Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20031101</creationdate><title>CHLOROQUINE-RESISTANT PLASMODIUM VIVAX MALARIA IN PERU</title><author>RUEBUSH, TRENTON K., II ; ZEGARRA, JORGE ; CAIRO, JAVIER ; ANDERSEN, ELLEN M ; GREEN, MICHAEL ; PILLAI, DYLAN R ; MARQUINO, WILMER ; HUILCA, MARIA ; AREVALO, ERNESTO ; GARCIA, CORALITH ; SOLARY, LELY ; KAIN, KEVIN C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-a34c911fdefecd9d9eeae79068369755fdab81088eb6004a2ef2b83d9c4e7cd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Animals</topic><topic>Antimalarials - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chloroquine - pharmacology</topic><topic>DNA, Protozoan - analysis</topic><topic>Drug Resistance</topic><topic>Female</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Malaria</topic><topic>Malaria, Vivax - epidemiology</topic><topic>Malaria, Vivax - parasitology</topic><topic>Malaria, Vivax - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>parasitemia</topic><topic>Parasitic diseases</topic><topic>Peru - epidemiology</topic><topic>Plasmodium vivax</topic><topic>Plasmodium vivax - drug effects</topic><topic>Plasmodium vivax - genetics</topic><topic>Polymerase Chain Reaction</topic><topic>Protozoal diseases</topic><topic>Recurrence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RUEBUSH, TRENTON K., II</creatorcontrib><creatorcontrib>ZEGARRA, JORGE</creatorcontrib><creatorcontrib>CAIRO, JAVIER</creatorcontrib><creatorcontrib>ANDERSEN, ELLEN M</creatorcontrib><creatorcontrib>GREEN, MICHAEL</creatorcontrib><creatorcontrib>PILLAI, DYLAN R</creatorcontrib><creatorcontrib>MARQUINO, WILMER</creatorcontrib><creatorcontrib>HUILCA, MARIA</creatorcontrib><creatorcontrib>AREVALO, ERNESTO</creatorcontrib><creatorcontrib>GARCIA, CORALITH</creatorcontrib><creatorcontrib>SOLARY, LELY</creatorcontrib><creatorcontrib>KAIN, KEVIN C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RUEBUSH, TRENTON K., II</au><au>ZEGARRA, JORGE</au><au>CAIRO, JAVIER</au><au>ANDERSEN, ELLEN M</au><au>GREEN, MICHAEL</au><au>PILLAI, DYLAN R</au><au>MARQUINO, WILMER</au><au>HUILCA, MARIA</au><au>AREVALO, ERNESTO</au><au>GARCIA, CORALITH</au><au>SOLARY, LELY</au><au>KAIN, KEVIN C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CHLOROQUINE-RESISTANT PLASMODIUM VIVAX MALARIA IN PERU</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>2003-11-01</date><risdate>2003</risdate><volume>69</volume><issue>5</issue><spage>548</spage><epage>552</epage><pages>548-552</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><coden>AJTHAB</coden><abstract>Reports from several sites in South America suggest the presence of isolated cases of chloroquine-resistant Plasmodium vivax malaria. To investigate the possibility of chloroquine-resistant P. vivax in Peru, we conducted 28-day in vivo drug efficacy trials at three sites in the Amazon region and one site on the northern Pacific Coast between 1998 and 2001. A total of 242 patients between the ages of 2 and 60 years were enrolled (177 from the Amazon region and 65 from the northern coast). All subjects received directly observed therapy with chloroquine, 25 mg/kg, over a three-day period. On enrollment, 49% had a documented fever and 96% had a history of fever; their geometric mean parasite density was 5,129 parasites/microL. A total of 212 (88%) of the 242 subjects completed their 28-day follow-up. Four of the 177 patients from the Amazon region had a recurrence of P. vivax parasitemia on days 21 and 28 after treatment was initiated. Two of these patients had chloroquine-resistant infections, based on polymerase chain reaction-single-stranded conformational polymorphism genotyping and chloroquine-desethylchloroquine blood levels, which were > or = 97 ng/mL at the time of the reappearance of parasitemia. None of the subjects studied on the northern Pacific Coast had recurrent parasitemia.</abstract><cop>Lawrence, KS</cop><pub>ASTMH</pub><pmid>14695094</pmid><doi>10.4269/ajtmh.2003.69.548</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Animals Antimalarials - pharmacology Biological and medical sciences Child Child, Preschool Chloroquine - pharmacology DNA, Protozoan - analysis Drug Resistance Female Human protozoal diseases Humans Infectious diseases Malaria Malaria, Vivax - epidemiology Malaria, Vivax - parasitology Malaria, Vivax - pathology Male Medical sciences Middle Aged parasitemia Parasitic diseases Peru - epidemiology Plasmodium vivax Plasmodium vivax - drug effects Plasmodium vivax - genetics Polymerase Chain Reaction Protozoal diseases Recurrence |
| title | CHLOROQUINE-RESISTANT PLASMODIUM VIVAX MALARIA IN PERU |
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