Donor-specific tolerance in fully major histocompatibility major histocompatibility complex-mismatched limb allograft transplants under an anti-alphabeta T-cell receptor monoclonal antibody and cyclosporine A protocol

Recent studies have demonstrated that treatment with alphabeta-T-cell receptor (TCR) monoclonal antibody and cyclosporine A (CsA) can extend survival in composite tissue allografts (CTA). The purpose of this study was to induce tolerance in fully major histocompatibility complex (MHC)-mismatched rat...

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Veröffentlicht in:	Transplantation 2003-12, Vol.76 (12), p.1662-1668
Hauptverfasser:	Siemionow, Maria Z, Izycki, Dariusz M, Zielinski, Maciej
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - therapeutic use Cyclosporine - therapeutic use Flow Cytometry Graft Survival - drug effects Graft Survival - immunology Hindlimb - transplantation Histocompatibility Testing Immunosuppressive Agents - therapeutic use Lymphocyte Depletion Major Histocompatibility Complex Models, Animal Rats Rats, Inbred BN Rats, Inbred Lew Receptors, Antigen, T-Cell, alpha-beta - immunology Time Factors Transplantation, Homologous - immunology Transplantation, Homologous - pathology
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