Cytotoxic, antifouling bromotyramines: A synthetic study on simple marine natural products and Their analogues

Synthesis and biological evaluation of two naturally-occurring bromotyramines, moloka'iamine 1 and 3,5-dibromo-4-methoxy-β-phenethylamine 2, together with several analogues, have been completed. Bromotyramine 2 is cytotoxic, and was found to be a potent antifoulant. Analogues 15 and 16 also dis...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2002-03, Vol.12 (5), p.823-825
Hauptverfasser:	Schoenfeld, Ryan C., Conova, Susan, Rittschof, Daniel, Ganem, Bruce
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - pharmacology Antineoplastic agents Bacteria - growth & development Biological and medical sciences Cell Survival - drug effects Drug Screening Assays, Antitumor General aspects Humans Marine Biology Medical sciences Molecular Structure Pharmacology. Drug treatments Tumor Cells, Cultured - drug effects Tyramine - analogs & derivatives Tyramine - pharmacology
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