Budesonide reduces multidrug resistance-associated protein 1 expression in an airway epithelial cell line (Calu-1)

The objective of this study was to determine the expression and activity of multidrug resistance-associated protein (MRP1) in a human airway epithelial cell line (Calu-1) and to further assess whether budesonide, a potent antiasthma corticosteroid, alters the expression and activity of MRP1 in these...

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Veröffentlicht in:	European journal of pharmacology 2002-02, Vol.437 (1), p.9-17
Hauptverfasser:	Bandi, Nagesh, Kompella, Uday B
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Blotting, Western Bones, joints and connective tissue. Antiinflammatory agents Bronchodilator Agents - pharmacology Budesonide Budesonide - pharmacology Calu-1 cell Cell Line Cell Survival - drug effects Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Dose-Response Relationship, Drug Epithelial Cells - drug effects Epithelial Cells - metabolism Gene Expression Regulation - drug effects Humans Indomethacin - pharmacology Lung - cytology Lung - drug effects Lung - metabolism Medical sciences MRP (Multidrug resistance-associated protein) Multidrug Resistance-Associated Proteins - drug effects Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - metabolism Pharmacology. Drug treatments Probenecid - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism Time Factors Verapamil - pharmacology Vincristine - pharmacology
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