Estrogen Receptor-α Directs Ordered, Cyclical, and Combinatorial Recruitment of Cofactors on a Natural Target Promoter

Transcriptional activation of a gene involves an orchestrated recruitment of components of the basal transcription machinery and intermediate factors, concomitant with an alteration in local chromatin structure generated by posttranslational modifications of histone tails and nucleosome remodeling....

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Veröffentlicht in:	Cell 2003-12, Vol.115 (6), p.751-763
Hauptverfasser:	Métivier, Raphaël, Penot, Graziella, Hübner, Michael R, Reid, George, Brand, Heike, Koš, Martin, Gannon, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Clocks - genetics Cell Line, Tumor Epigenesis, Genetic - genetics Estrogen Receptor alpha Estrogens - metabolism Histone Deacetylases - genetics Humans Nucleosomes - genetics Promoter Regions, Genetic - genetics Proteins - genetics Proteins - metabolism Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Transcriptional Activation - genetics Trefoil Factor-1 Tumor Suppressor Proteins
Online-Zugang:	Volltext
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