Protective immune responses elicited in mice by immunization with formulations of poly(lactide-co-glycolide) microparticles

Parenteral administration of microparticle encapsulated DNA elicits immune responses to the encoded antigens. Experiments were performed to test whether the addition of certain lipophilic agents to such formulations enhanced the activity of a beta-galactosidase (β-gal) DNA vaccine. Addition of eithe...

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Veröffentlicht in:	Vaccine 2002-02, Vol.20 (11), p.1524-1531
Hauptverfasser:	McKeever, U, Barman, S, Hao, T, Chambers, P, Song, S, Lunsford, L, Hsu, Y.-Y, Roy, K, Hedley, M.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation Applied microbiology beta-Galactosidase - genetics beta-Galactosidase - immunology Biological and medical sciences Cancer Vaccines - administration & dosage Cell Line DNA DNA, Bacterial - genetics Drug Delivery Systems Fundamental and applied biological sciences. Psychology Histocompatibility Antigens Class I - metabolism Immunization - methods Lac Operon Mice Mice, Inbred BALB C Microbiology Microparticle Microspheres Neoplasms, Experimental - immunology Neoplasms, Experimental - prevention & control Particle Size PLG Polyglactin 910 - administration & dosage T-Lymphocytes - immunology Tumor Cells, Cultured Vaccine Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - administration & dosage Virology
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