The effects of acute afterload change on systolic ventricular function in conscious dogs with normal vs. failing hearts
Background: To date, no data exist on the linearity and, therefore, the usefulness of the preload recruitable stroke work (PRSW) and end‐systolic pressure–volume (ESPVR) relationships during acute afterload changes in heart failure. Aims: Our aim was, therefore, to characterize both relationships in...
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| Veröffentlicht in: | European journal of heart failure 2003-12, Vol.5 (6), p.741-749 |
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| container_title | European journal of heart failure |
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| creator | Thompson, Richard B. van den Bos, Ewout J. Esposito, David J. Owen, Clarence H. Glower, Donald D. |
| description | Background:
To date, no data exist on the linearity and, therefore, the usefulness of the preload recruitable stroke work (PRSW) and end‐systolic pressure–volume (ESPVR) relationships during acute afterload changes in heart failure.
Aims:
Our aim was, therefore, to characterize both relationships in a model of ventricular pacing induced heart failure at baseline and during acute changes in afterload.
Methods:
Dynamic left ventricular volume and transmural pressure were measured in 10 conscious dogs using sonomicrometry and micromanometry under control conditions and during heart failure produced by 3 weeks of rapid right ventricular pacing. Afterload was varied from baseline with intravenous infusions of nitroprusside and phenylephrine. Left ventricular function was assessed using the PRSW and ESPVR relationships.
Results:
Cardiac output demonstrated a linear inverse relationship with afterload in both normal and failing hearts (r2>0.5, P |
| doi_str_mv | 10.1016/S1388-9842(03)00152-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71475644</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71475644</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4451-4e8bc4f7215ec8f23c4d8b29bb3c7c90b56e4e6a5dd06d47e0c3406d117e17653</originalsourceid><addsrcrecordid>eNqNkE1vEzEQhi0EoqXwE0A-IThssXf9lQtSVfWDKgUhChwtr3ecGBy72N6m-ffdNoFeOc1I88w7oweh15QcUkLFh2-0U6qZKda-I917QihvG_oE7VMlZw1RjD2d-r_IHnpRyq8JkoS0z9EeZUJyxdt9tL5aAgbnwNaCk8PGjhWwcRVySGbAdmniAnCKuGxKTcFbfAOxZm_HYDJ2Y7TVT1MfsU2xWJ_Ggoe0KHjt6xLHlFcm4JtyiJ3xwccFXoLJtbxEz5wJBV7t6gH6fnpydXzezL-cfTo-mjeWMU4bBqq3zMmWcrDKtZ1lg-rbWd93VtoZ6bkABsLwYSBiYBKI7djUUSqBSsG7A_R2m3ud058RStUrXyyEYCJMr2pJmeSCsQnkW9DmVEoGp6-zX5m80ZToe-P6wbi-16lJpx-MazrtvdkdGPsVDI9bO8UT8HELrH2Azf-l6pOL89PHC802wJcKt_8CTP6thewk1z8_n2nx4_KCyMu5_trdAZGqnyY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71475644</pqid></control><display><type>article</type><title>The effects of acute afterload change on systolic ventricular function in conscious dogs with normal vs. failing hearts</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Thompson, Richard B. ; van den Bos, Ewout J. ; Esposito, David J. ; Owen, Clarence H. ; Glower, Donald D.</creator><creatorcontrib>Thompson, Richard B. ; van den Bos, Ewout J. ; Esposito, David J. ; Owen, Clarence H. ; Glower, Donald D.</creatorcontrib><description>Background:
To date, no data exist on the linearity and, therefore, the usefulness of the preload recruitable stroke work (PRSW) and end‐systolic pressure–volume (ESPVR) relationships during acute afterload changes in heart failure.
Aims:
Our aim was, therefore, to characterize both relationships in a model of ventricular pacing induced heart failure at baseline and during acute changes in afterload.
Methods:
Dynamic left ventricular volume and transmural pressure were measured in 10 conscious dogs using sonomicrometry and micromanometry under control conditions and during heart failure produced by 3 weeks of rapid right ventricular pacing. Afterload was varied from baseline with intravenous infusions of nitroprusside and phenylephrine. Left ventricular function was assessed using the PRSW and ESPVR relationships.
Results:
Cardiac output demonstrated a linear inverse relationship with afterload in both normal and failing hearts (r2>0.5, P<0.001) with failure producing a parallel, downward shift of the afterload (x) vs. cardiac output (y) relationship (P<0.01). Yet, afterload variation did not affect PRSW or ESPVR relationships in either normal or failing hearts (r2<0.12, P>0.05).
Conclusion:
Thus, the PRSW and ESPVR relationships are insensitive to acute afterload changes in both failing and normal hearts, and the failing left ventricle is no more afterload‐sensitive than the normal heart.</description><identifier>ISSN: 1388-9842</identifier><identifier>EISSN: 1879-0844</identifier><identifier>DOI: 10.1016/S1388-9842(03)00152-1</identifier><identifier>PMID: 14675852</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>afterload ; Animals ; arterial resistance ; Blood Pressure ; Cardiac Output - physiology ; Cardiac Pacing, Artificial ; cardiomyopathy ; Disease Models, Animal ; Dogs ; Echocardiography ; Heart Failure - physiopathology ; Linear Models ; Nitroprusside - pharmacology ; pacing ; Phenylephrine - pharmacology ; Stroke Volume - drug effects ; Stroke Volume - physiology ; tachycardia ; Vasoconstrictor Agents - pharmacology ; Vasodilator Agents - pharmacology ; ventricular function ; Ventricular Function, Left - drug effects ; Ventricular Function, Left - physiology</subject><ispartof>European journal of heart failure, 2003-12, Vol.5 (6), p.741-749</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © 2003 the Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4451-4e8bc4f7215ec8f23c4d8b29bb3c7c90b56e4e6a5dd06d47e0c3406d117e17653</citedby><cites>FETCH-LOGICAL-c4451-4e8bc4f7215ec8f23c4d8b29bb3c7c90b56e4e6a5dd06d47e0c3406d117e17653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2FS1388-9842%2803%2900152-1$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2FS1388-9842%2803%2900152-1$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14675852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thompson, Richard B.</creatorcontrib><creatorcontrib>van den Bos, Ewout J.</creatorcontrib><creatorcontrib>Esposito, David J.</creatorcontrib><creatorcontrib>Owen, Clarence H.</creatorcontrib><creatorcontrib>Glower, Donald D.</creatorcontrib><title>The effects of acute afterload change on systolic ventricular function in conscious dogs with normal vs. failing hearts</title><title>European journal of heart failure</title><addtitle>European Journal of Heart Failure</addtitle><description>Background:
To date, no data exist on the linearity and, therefore, the usefulness of the preload recruitable stroke work (PRSW) and end‐systolic pressure–volume (ESPVR) relationships during acute afterload changes in heart failure.
Aims:
Our aim was, therefore, to characterize both relationships in a model of ventricular pacing induced heart failure at baseline and during acute changes in afterload.
Methods:
Dynamic left ventricular volume and transmural pressure were measured in 10 conscious dogs using sonomicrometry and micromanometry under control conditions and during heart failure produced by 3 weeks of rapid right ventricular pacing. Afterload was varied from baseline with intravenous infusions of nitroprusside and phenylephrine. Left ventricular function was assessed using the PRSW and ESPVR relationships.
Results:
Cardiac output demonstrated a linear inverse relationship with afterload in both normal and failing hearts (r2>0.5, P<0.001) with failure producing a parallel, downward shift of the afterload (x) vs. cardiac output (y) relationship (P<0.01). Yet, afterload variation did not affect PRSW or ESPVR relationships in either normal or failing hearts (r2<0.12, P>0.05).
Conclusion:
Thus, the PRSW and ESPVR relationships are insensitive to acute afterload changes in both failing and normal hearts, and the failing left ventricle is no more afterload‐sensitive than the normal heart.</description><subject>afterload</subject><subject>Animals</subject><subject>arterial resistance</subject><subject>Blood Pressure</subject><subject>Cardiac Output - physiology</subject><subject>Cardiac Pacing, Artificial</subject><subject>cardiomyopathy</subject><subject>Disease Models, Animal</subject><subject>Dogs</subject><subject>Echocardiography</subject><subject>Heart Failure - physiopathology</subject><subject>Linear Models</subject><subject>Nitroprusside - pharmacology</subject><subject>pacing</subject><subject>Phenylephrine - pharmacology</subject><subject>Stroke Volume - drug effects</subject><subject>Stroke Volume - physiology</subject><subject>tachycardia</subject><subject>Vasoconstrictor Agents - pharmacology</subject><subject>Vasodilator Agents - pharmacology</subject><subject>ventricular function</subject><subject>Ventricular Function, Left - drug effects</subject><subject>Ventricular Function, Left - physiology</subject><issn>1388-9842</issn><issn>1879-0844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1vEzEQhi0EoqXwE0A-IThssXf9lQtSVfWDKgUhChwtr3ecGBy72N6m-ffdNoFeOc1I88w7oweh15QcUkLFh2-0U6qZKda-I917QihvG_oE7VMlZw1RjD2d-r_IHnpRyq8JkoS0z9EeZUJyxdt9tL5aAgbnwNaCk8PGjhWwcRVySGbAdmniAnCKuGxKTcFbfAOxZm_HYDJ2Y7TVT1MfsU2xWJ_Ggoe0KHjt6xLHlFcm4JtyiJ3xwccFXoLJtbxEz5wJBV7t6gH6fnpydXzezL-cfTo-mjeWMU4bBqq3zMmWcrDKtZ1lg-rbWd93VtoZ6bkABsLwYSBiYBKI7djUUSqBSsG7A_R2m3ud058RStUrXyyEYCJMr2pJmeSCsQnkW9DmVEoGp6-zX5m80ZToe-P6wbi-16lJpx-MazrtvdkdGPsVDI9bO8UT8HELrH2Azf-l6pOL89PHC802wJcKt_8CTP6thewk1z8_n2nx4_KCyMu5_trdAZGqnyY</recordid><startdate>200312</startdate><enddate>200312</enddate><creator>Thompson, Richard B.</creator><creator>van den Bos, Ewout J.</creator><creator>Esposito, David J.</creator><creator>Owen, Clarence H.</creator><creator>Glower, Donald D.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200312</creationdate><title>The effects of acute afterload change on systolic ventricular function in conscious dogs with normal vs. failing hearts</title><author>Thompson, Richard B. ; van den Bos, Ewout J. ; Esposito, David J. ; Owen, Clarence H. ; Glower, Donald D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4451-4e8bc4f7215ec8f23c4d8b29bb3c7c90b56e4e6a5dd06d47e0c3406d117e17653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>afterload</topic><topic>Animals</topic><topic>arterial resistance</topic><topic>Blood Pressure</topic><topic>Cardiac Output - physiology</topic><topic>Cardiac Pacing, Artificial</topic><topic>cardiomyopathy</topic><topic>Disease Models, Animal</topic><topic>Dogs</topic><topic>Echocardiography</topic><topic>Heart Failure - physiopathology</topic><topic>Linear Models</topic><topic>Nitroprusside - pharmacology</topic><topic>pacing</topic><topic>Phenylephrine - pharmacology</topic><topic>Stroke Volume - drug effects</topic><topic>Stroke Volume - physiology</topic><topic>tachycardia</topic><topic>Vasoconstrictor Agents - pharmacology</topic><topic>Vasodilator Agents - pharmacology</topic><topic>ventricular function</topic><topic>Ventricular Function, Left - drug effects</topic><topic>Ventricular Function, Left - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thompson, Richard B.</creatorcontrib><creatorcontrib>van den Bos, Ewout J.</creatorcontrib><creatorcontrib>Esposito, David J.</creatorcontrib><creatorcontrib>Owen, Clarence H.</creatorcontrib><creatorcontrib>Glower, Donald D.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of heart failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thompson, Richard B.</au><au>van den Bos, Ewout J.</au><au>Esposito, David J.</au><au>Owen, Clarence H.</au><au>Glower, Donald D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of acute afterload change on systolic ventricular function in conscious dogs with normal vs. failing hearts</atitle><jtitle>European journal of heart failure</jtitle><addtitle>European Journal of Heart Failure</addtitle><date>2003-12</date><risdate>2003</risdate><volume>5</volume><issue>6</issue><spage>741</spage><epage>749</epage><pages>741-749</pages><issn>1388-9842</issn><eissn>1879-0844</eissn><abstract>Background:
To date, no data exist on the linearity and, therefore, the usefulness of the preload recruitable stroke work (PRSW) and end‐systolic pressure–volume (ESPVR) relationships during acute afterload changes in heart failure.
Aims:
Our aim was, therefore, to characterize both relationships in a model of ventricular pacing induced heart failure at baseline and during acute changes in afterload.
Methods:
Dynamic left ventricular volume and transmural pressure were measured in 10 conscious dogs using sonomicrometry and micromanometry under control conditions and during heart failure produced by 3 weeks of rapid right ventricular pacing. Afterload was varied from baseline with intravenous infusions of nitroprusside and phenylephrine. Left ventricular function was assessed using the PRSW and ESPVR relationships.
Results:
Cardiac output demonstrated a linear inverse relationship with afterload in both normal and failing hearts (r2>0.5, P<0.001) with failure producing a parallel, downward shift of the afterload (x) vs. cardiac output (y) relationship (P<0.01). Yet, afterload variation did not affect PRSW or ESPVR relationships in either normal or failing hearts (r2<0.12, P>0.05).
Conclusion:
Thus, the PRSW and ESPVR relationships are insensitive to acute afterload changes in both failing and normal hearts, and the failing left ventricle is no more afterload‐sensitive than the normal heart.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>14675852</pmid><doi>10.1016/S1388-9842(03)00152-1</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | afterload Animals arterial resistance Blood Pressure Cardiac Output - physiology Cardiac Pacing, Artificial cardiomyopathy Disease Models, Animal Dogs Echocardiography Heart Failure - physiopathology Linear Models Nitroprusside - pharmacology pacing Phenylephrine - pharmacology Stroke Volume - drug effects Stroke Volume - physiology tachycardia Vasoconstrictor Agents - pharmacology Vasodilator Agents - pharmacology ventricular function Ventricular Function, Left - drug effects Ventricular Function, Left - physiology |
| title | The effects of acute afterload change on systolic ventricular function in conscious dogs with normal vs. failing hearts |
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