Axoplasmic Importins Enable Retrograde Injury Signaling in Lesioned Nerve

Axoplasmic proteins containing nuclear localization signals (NLS) signal retrogradely by an unknown mechanism in injured nerve. Here we demonstrate that the importin/karyopherin α and β families underlie this process. We show that importins are found in axons at significant distances from the cell b...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2003-12, Vol.40 (6), p.1095-1104
Hauptverfasser:	Hanz, Shlomit, Perlson, Eran, Willis, Dianna, Zheng, Jun-Qi, Massarwa, R'ada, Huerta, Juan J., Koltzenburg, Martin, Kohler, Matthias, van-Minnen, Jan, Twiss, Jeffery L., Fainzilber, Mike
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axonal Transport - physiology Cells, Cultured Humans karyopherins Karyopherins - biosynthesis Karyopherins - genetics Male Medical research Mice Mice, Inbred C57BL Neurons nuclear localization signal Peptides Proteins Rats Rats, Sprague-Dawley Retrograde Degeneration - genetics Retrograde Degeneration - metabolism RNA, Messenger - biosynthesis RNA, Messenger - genetics Rodents Sciatic Neuropathy - genetics Sciatic Neuropathy - metabolism Up-Regulation - physiology
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