Variable continental distribution of polymorphisms in the coding regions of DNA-repair genes

DNA-repair pathways are critical for maintaining the integrity of the genetic material by protecting against mutations due to exposure-induced damages or replication errors. Polymorphisms in the corresponding genes may be relevant in genetic epidemiology by modifying individual cancer susceptibility...

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Veröffentlicht in:	Journal of human genetics 2003-12, Vol.48 (12), p.659-664
Hauptverfasser:	Mathonnet, Géraldine, Labuda, Damian, Meloche, Caroline, Wambach, Tina, Krajinovic, Maja, Sinnett, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acids - chemistry Biomedicine Deoxyribonucleic acid DNA DNA Damage DNA Repair Emigration and Immigration Epidemiology Exons Gene Expression Gene Frequency Gene Function Gene Therapy Genetic Drift Genetic engineering Genetic Predisposition to Disease Genotype Haplotypes Human Genetics Humans Models, Statistical Molecular Medicine Original Article Polymorphism, Genetic Population distribution Population genetics XRCC1 protein
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