Glutamate, dopamine, and schizophrenia: from pathophysiology to treatment

The fundamental pathological process(es) associated with schizophrenia remain(s) uncertain, but multiple lines of evidence suggest that this condition is associated with (1) excessive stimulation of striatal dopamine (DA) D2 receptors, (2) deficient stimulation of prefrontal DA D1 receptors and, (3)...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2003-11, Vol.1003 (1), p.138-158
Hauptverfasser:	Laruelle, Marc, Kegeles, Lawrence S, Abi-Dargham, Anissa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cerebral Cortex - physiopathology Dopamine - physiology Glutamates - physiology Humans Neostriatum - physiopathology Prefrontal Cortex - physiopathology Receptors, N-Methyl-D-Aspartate - physiology Schizophrenia - drug therapy Schizophrenia - pathology Schizophrenia - physiopathology
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