Esophagogastric varices as a prognostic factor for the determination of clinical stage in patients with primary biliary cirrhosis
Primary biliary cirrhosis (PBC) is usually classified as either asymptomatic PBC (a-PBC) or symptomatic PBC (s-PBC). Although the proportion of a-PBC versus s-PBC patients has been consistently increasing, it is not clear whether the present criteria for the staging of PBC are optimal or not. We inv...
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| Veröffentlicht in: | Journal of gastroenterology 2003-11, Vol.38 (11), p.1060-1065 |
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| creator | Takeshita, Eiji Kumagi, Teru Matsui, Hidetaka Abe, Masanori Furukawa, Shinya Ikeda, Yoshiou Matsuura, Bunzo Michitaka, Kojiro Horiike, Norio Onji, Morikazu |
| description | Primary biliary cirrhosis (PBC) is usually classified as either asymptomatic PBC (a-PBC) or symptomatic PBC (s-PBC). Although the proportion of a-PBC versus s-PBC patients has been consistently increasing, it is not clear whether the present criteria for the staging of PBC are optimal or not. We investigated the clinical stage of PBC patients from the standpoint of esophagogastric varices (EGV).
One hundred and nine PBC patients were enrolled in this retrospective study. We investigated the clinical features of PBC based on laboratory data, histological stage, symptoms, and existence of EGV. In addition, the clinical course and prognosis in patients who were periodically followed up were also studied.
(1) EGV was detected in a-PBC patients, and there was no difference in the grade of EGV between a-PBC and s-PBC patients. (2) a-PBC patients with EGV had more liver damage than those without EGV, and a-PBC patients with EGV had a poorer prognosis than those without EGV. (3) Three of 11 patients who progressed from a-PBC to s-PBC within 3 years had EGV. (4) One of 3 a-PBC patients with EGV had progressed to s-PBC at 3-year follow-up.
These results indicate that EGV is one of the most important factors for evaluating PBC. Therefore, we would like to propose that a-PBC patients with EGV should either be included in the presently defined s-PBC class, or that new prognostic classes of PBC be created that include EGV as a prognostic factor. |
| doi_str_mv | 10.1007/s00535-003-1196-6 |
| format | Article |
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One hundred and nine PBC patients were enrolled in this retrospective study. We investigated the clinical features of PBC based on laboratory data, histological stage, symptoms, and existence of EGV. In addition, the clinical course and prognosis in patients who were periodically followed up were also studied.
(1) EGV was detected in a-PBC patients, and there was no difference in the grade of EGV between a-PBC and s-PBC patients. (2) a-PBC patients with EGV had more liver damage than those without EGV, and a-PBC patients with EGV had a poorer prognosis than those without EGV. (3) Three of 11 patients who progressed from a-PBC to s-PBC within 3 years had EGV. (4) One of 3 a-PBC patients with EGV had progressed to s-PBC at 3-year follow-up.
These results indicate that EGV is one of the most important factors for evaluating PBC. Therefore, we would like to propose that a-PBC patients with EGV should either be included in the presently defined s-PBC class, or that new prognostic classes of PBC be created that include EGV as a prognostic factor.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-003-1196-6</identifier><identifier>PMID: 14673723</identifier><language>eng</language><publisher>Japan: Springer Nature B.V</publisher><subject>Adult ; Aged ; Disease Progression ; Esophageal and Gastric Varices - etiology ; Female ; Humans ; Liver Cirrhosis, Biliary - classification ; Liver Cirrhosis, Biliary - complications ; Male ; Middle Aged ; Prognosis ; Proportional Hazards Models</subject><ispartof>Journal of gastroenterology, 2003-11, Vol.38 (11), p.1060-1065</ispartof><rights>Copyright Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-245b6976eae8ba427d320d5ab5d5a59fea0dbca9ea10e80f917cf26308b779bc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14673723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takeshita, Eiji</creatorcontrib><creatorcontrib>Kumagi, Teru</creatorcontrib><creatorcontrib>Matsui, Hidetaka</creatorcontrib><creatorcontrib>Abe, Masanori</creatorcontrib><creatorcontrib>Furukawa, Shinya</creatorcontrib><creatorcontrib>Ikeda, Yoshiou</creatorcontrib><creatorcontrib>Matsuura, Bunzo</creatorcontrib><creatorcontrib>Michitaka, Kojiro</creatorcontrib><creatorcontrib>Horiike, Norio</creatorcontrib><creatorcontrib>Onji, Morikazu</creatorcontrib><title>Esophagogastric varices as a prognostic factor for the determination of clinical stage in patients with primary biliary cirrhosis</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><description>Primary biliary cirrhosis (PBC) is usually classified as either asymptomatic PBC (a-PBC) or symptomatic PBC (s-PBC). Although the proportion of a-PBC versus s-PBC patients has been consistently increasing, it is not clear whether the present criteria for the staging of PBC are optimal or not. We investigated the clinical stage of PBC patients from the standpoint of esophagogastric varices (EGV).
One hundred and nine PBC patients were enrolled in this retrospective study. We investigated the clinical features of PBC based on laboratory data, histological stage, symptoms, and existence of EGV. In addition, the clinical course and prognosis in patients who were periodically followed up were also studied.
(1) EGV was detected in a-PBC patients, and there was no difference in the grade of EGV between a-PBC and s-PBC patients. (2) a-PBC patients with EGV had more liver damage than those without EGV, and a-PBC patients with EGV had a poorer prognosis than those without EGV. (3) Three of 11 patients who progressed from a-PBC to s-PBC within 3 years had EGV. (4) One of 3 a-PBC patients with EGV had progressed to s-PBC at 3-year follow-up.
These results indicate that EGV is one of the most important factors for evaluating PBC. Therefore, we would like to propose that a-PBC patients with EGV should either be included in the presently defined s-PBC class, or that new prognostic classes of PBC be created that include EGV as a prognostic factor.</description><subject>Adult</subject><subject>Aged</subject><subject>Disease Progression</subject><subject>Esophageal and Gastric Varices - etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Liver Cirrhosis, Biliary - classification</subject><subject>Liver Cirrhosis, Biliary - complications</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkU1rHDEMhk1JaTZpf0AvxeTQ26Tyx4zHxxLSJhDIJT0bjUez6zA73trehh7zz-tlFwoBWwLp1YvEw9hnAdcCwHzLAK1qGwDVCGG7pnvHVkLXSmulPGMrsFrXjtHn7CLnZwChoO0_sHOhO6OMVCv2epvjboPruMZcUvD8D9ZImWN9fJfieom51PqEvsTEp_rLhvhIhdI2LFhCXHicuJ_DEjzOPBdcEw8L39UeLSXzl1A21SpsMf3lQ5jDIfuQ0ibmkD-y9xPOmT6d8iX79eP26eaueXj8eX_z_aHxypjSSN0OnTUdIfUDamlGJWFscWhraO1ECOPg0RIKoB4mK4yfZKegH4yxg1eX7OvRtx71e0-5uG3InuYZF4r77IzQRkvbV-HVG-Fz3Kel7uakMKIz0B9E4ijyKeacaHKnA50Ad4DjjnBcheMOcFxXZ76cjPfDlsb_Eyca6h9UIY1H</recordid><startdate>200311</startdate><enddate>200311</enddate><creator>Takeshita, Eiji</creator><creator>Kumagi, Teru</creator><creator>Matsui, Hidetaka</creator><creator>Abe, Masanori</creator><creator>Furukawa, Shinya</creator><creator>Ikeda, Yoshiou</creator><creator>Matsuura, Bunzo</creator><creator>Michitaka, Kojiro</creator><creator>Horiike, Norio</creator><creator>Onji, Morikazu</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200311</creationdate><title>Esophagogastric varices as a prognostic factor for the determination of clinical stage in patients with primary biliary cirrhosis</title><author>Takeshita, Eiji ; Kumagi, Teru ; Matsui, Hidetaka ; Abe, Masanori ; Furukawa, Shinya ; Ikeda, Yoshiou ; Matsuura, Bunzo ; Michitaka, Kojiro ; Horiike, Norio ; Onji, Morikazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-245b6976eae8ba427d320d5ab5d5a59fea0dbca9ea10e80f917cf26308b779bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Disease Progression</topic><topic>Esophageal and Gastric Varices - etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Liver Cirrhosis, Biliary - classification</topic><topic>Liver Cirrhosis, Biliary - complications</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takeshita, Eiji</creatorcontrib><creatorcontrib>Kumagi, Teru</creatorcontrib><creatorcontrib>Matsui, Hidetaka</creatorcontrib><creatorcontrib>Abe, Masanori</creatorcontrib><creatorcontrib>Furukawa, Shinya</creatorcontrib><creatorcontrib>Ikeda, Yoshiou</creatorcontrib><creatorcontrib>Matsuura, Bunzo</creatorcontrib><creatorcontrib>Michitaka, Kojiro</creatorcontrib><creatorcontrib>Horiike, Norio</creatorcontrib><creatorcontrib>Onji, Morikazu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takeshita, Eiji</au><au>Kumagi, Teru</au><au>Matsui, Hidetaka</au><au>Abe, Masanori</au><au>Furukawa, Shinya</au><au>Ikeda, Yoshiou</au><au>Matsuura, Bunzo</au><au>Michitaka, Kojiro</au><au>Horiike, Norio</au><au>Onji, Morikazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Esophagogastric varices as a prognostic factor for the determination of clinical stage in patients with primary biliary cirrhosis</atitle><jtitle>Journal of gastroenterology</jtitle><addtitle>J Gastroenterol</addtitle><date>2003-11</date><risdate>2003</risdate><volume>38</volume><issue>11</issue><spage>1060</spage><epage>1065</epage><pages>1060-1065</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>Primary biliary cirrhosis (PBC) is usually classified as either asymptomatic PBC (a-PBC) or symptomatic PBC (s-PBC). Although the proportion of a-PBC versus s-PBC patients has been consistently increasing, it is not clear whether the present criteria for the staging of PBC are optimal or not. We investigated the clinical stage of PBC patients from the standpoint of esophagogastric varices (EGV).
One hundred and nine PBC patients were enrolled in this retrospective study. We investigated the clinical features of PBC based on laboratory data, histological stage, symptoms, and existence of EGV. In addition, the clinical course and prognosis in patients who were periodically followed up were also studied.
(1) EGV was detected in a-PBC patients, and there was no difference in the grade of EGV between a-PBC and s-PBC patients. (2) a-PBC patients with EGV had more liver damage than those without EGV, and a-PBC patients with EGV had a poorer prognosis than those without EGV. (3) Three of 11 patients who progressed from a-PBC to s-PBC within 3 years had EGV. (4) One of 3 a-PBC patients with EGV had progressed to s-PBC at 3-year follow-up.
These results indicate that EGV is one of the most important factors for evaluating PBC. Therefore, we would like to propose that a-PBC patients with EGV should either be included in the presently defined s-PBC class, or that new prognostic classes of PBC be created that include EGV as a prognostic factor.</abstract><cop>Japan</cop><pub>Springer Nature B.V</pub><pmid>14673723</pmid><doi>10.1007/s00535-003-1196-6</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Disease Progression Esophageal and Gastric Varices - etiology Female Humans Liver Cirrhosis, Biliary - classification Liver Cirrhosis, Biliary - complications Male Middle Aged Prognosis Proportional Hazards Models |
| title | Esophagogastric varices as a prognostic factor for the determination of clinical stage in patients with primary biliary cirrhosis |
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