Birth order and sibship size as independent risk factors for asthma, allergy, and eczema
This study was carried out to disentangle the independent relations of birth order and sibship size with the presence of asthma, allergy and eczema. In a retrospective study, 700 families in the Netherlands were selected with index children born in 1988–90. Data were extracted from reports of health...
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| Veröffentlicht in: | Pediatric allergy and immunology 2003-12, Vol.14 (6), p.464-469 |
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| creator | Bernsen, Roos M. D. de Jongste, Johan C. van der Wouden, Johannes C. |
| description | This study was carried out to disentangle the independent relations of birth order and sibship size with the presence of asthma, allergy and eczema. In a retrospective study, 700 families in the Netherlands were selected with index children born in 1988–90. Data were extracted from reports of health examinations at the age of 6 years of these children and their siblings. Birth order, and not sibship size, appeared to be a strong risk factor for allergy (excluding eczema). Children with higher birth order had a lower risk of allergy compared with first‐borns (adjusted odds ratios: 0.43, 0.26 and 0.05 for second‐, third‐ and fourth‐ or higher borns, respectively; p |
| doi_str_mv | 10.1046/j.0905-6157.2003.00108.x |
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D. ; de Jongste, Johan C. ; van der Wouden, Johannes C.</creator><creatorcontrib>Bernsen, Roos M. D. ; de Jongste, Johan C. ; van der Wouden, Johannes C.</creatorcontrib><description>This study was carried out to disentangle the independent relations of birth order and sibship size with the presence of asthma, allergy and eczema. In a retrospective study, 700 families in the Netherlands were selected with index children born in 1988–90. Data were extracted from reports of health examinations at the age of 6 years of these children and their siblings. Birth order, and not sibship size, appeared to be a strong risk factor for allergy (excluding eczema). Children with higher birth order had a lower risk of allergy compared with first‐borns (adjusted odds ratios: 0.43, 0.26 and 0.05 for second‐, third‐ and fourth‐ or higher borns, respectively; p < 0.0001). Allergy including eczema also had a significant relation with birth order (p = 0.01). For asthma there appeared no clear relation with birth order. For asthma a non‐significant relationship with sibship size (adjusted for birth order) was found (p = 0.06): first‐born children in small sibships were more at risk than those in larger sibships. For allergy and eczema no such trend was observed. In conclusion, birth order is inversely related to the risk of allergy, independent of the size of the sibship.</description><identifier>ISSN: 0905-6157</identifier><identifier>EISSN: 1399-3038</identifier><identifier>DOI: 10.1046/j.0905-6157.2003.00108.x</identifier><identifier>PMID: 14675474</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>allergy ; asthma ; Asthma - epidemiology ; Biological and medical sciences ; Birth Order ; Child ; Child Welfare ; eczema ; Eczema - epidemiology ; Family Characteristics ; Family Health ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; General aspects ; Humans ; Hypersensitivity, Immediate - epidemiology ; Male ; Medical sciences ; Multivariate Analysis ; Netherlands - epidemiology ; Prevalence ; Retrospective Studies ; Risk Factors ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Siblings ; sibship size ; Statistics as Topic</subject><ispartof>Pediatric allergy and immunology, 2003-12, Vol.14 (6), p.464-469</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5298-6dae18ae8473314a5cce8dc423fd288576e7696db25f3c15cf61bf61fcc01c293</citedby><cites>FETCH-LOGICAL-c5298-6dae18ae8473314a5cce8dc423fd288576e7696db25f3c15cf61bf61fcc01c293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.0905-6157.2003.00108.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.0905-6157.2003.00108.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15348568$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14675474$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bernsen, Roos M. D.</creatorcontrib><creatorcontrib>de Jongste, Johan C.</creatorcontrib><creatorcontrib>van der Wouden, Johannes C.</creatorcontrib><title>Birth order and sibship size as independent risk factors for asthma, allergy, and eczema</title><title>Pediatric allergy and immunology</title><addtitle>Pediatr Allergy Immunol</addtitle><description>This study was carried out to disentangle the independent relations of birth order and sibship size with the presence of asthma, allergy and eczema. In a retrospective study, 700 families in the Netherlands were selected with index children born in 1988–90. Data were extracted from reports of health examinations at the age of 6 years of these children and their siblings. Birth order, and not sibship size, appeared to be a strong risk factor for allergy (excluding eczema). Children with higher birth order had a lower risk of allergy compared with first‐borns (adjusted odds ratios: 0.43, 0.26 and 0.05 for second‐, third‐ and fourth‐ or higher borns, respectively; p < 0.0001). Allergy including eczema also had a significant relation with birth order (p = 0.01). For asthma there appeared no clear relation with birth order. For asthma a non‐significant relationship with sibship size (adjusted for birth order) was found (p = 0.06): first‐born children in small sibships were more at risk than those in larger sibships. For allergy and eczema no such trend was observed. In conclusion, birth order is inversely related to the risk of allergy, independent of the size of the sibship.</description><subject>allergy</subject><subject>asthma</subject><subject>Asthma - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Birth Order</subject><subject>Child</subject><subject>Child Welfare</subject><subject>eczema</subject><subject>Eczema - epidemiology</subject><subject>Family Characteristics</subject><subject>Family Health</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>General aspects</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Netherlands - epidemiology</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Siblings</subject><subject>sibship size</subject><subject>Statistics as Topic</subject><issn>0905-6157</issn><issn>1399-3038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtvEzEURi0EomnLX0DewKoz2OPnSGxKRB9SVVi00J3leK6J03kEeyKS_vo6TdQu6cK-Xpzvu9ZBCFNSUsLll0VJaiIKSYUqK0JYSQgluly_QRPK6rpghOm3aPIMHaDDlBYZUkzS9-iAcqkEV3yC7r6FOM7xEBuI2PYNTmGW5mGZ5wNgm3DoG1hCvvoRx5DusbduHGLCfsiBNM47e4Jt20L8szl5agD3AJ09Ru-8bRN82M8jdHv2_WZ6UVz9OL-cnl4VTlS1LmRjgWoLmivGKLfCOdCN4xXzTaW1UBKUrGUzq4RnjgrnJZ3l450j1FU1O0Kfd73LOPxdQRpNF5KDtrU9DKtkFM3NXIn_grTmLMujGdQ70MUhpQjeLGPobNwYSsxWv1mYrVmzNWu2-s2TfrPO0Y_7HatZB81LcO87A5_2gE3Otj7a3oX0wgnGtZA6c1933L_QwubVHzA_Ty_zI8eLXTykEdbPcRvvjVRMCfP7-txcTFVV353dmF_sEbkJrv0</recordid><startdate>200312</startdate><enddate>200312</enddate><creator>Bernsen, Roos M. D.</creator><creator>de Jongste, Johan C.</creator><creator>van der Wouden, Johannes C.</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200312</creationdate><title>Birth order and sibship size as independent risk factors for asthma, allergy, and eczema</title><author>Bernsen, Roos M. D. ; de Jongste, Johan C. ; van der Wouden, Johannes C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5298-6dae18ae8473314a5cce8dc423fd288576e7696db25f3c15cf61bf61fcc01c293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>allergy</topic><topic>asthma</topic><topic>Asthma - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Birth Order</topic><topic>Child</topic><topic>Child Welfare</topic><topic>eczema</topic><topic>Eczema - epidemiology</topic><topic>Family Characteristics</topic><topic>Family Health</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>General aspects</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Netherlands - epidemiology</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Siblings</topic><topic>sibship size</topic><topic>Statistics as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bernsen, Roos M. D.</creatorcontrib><creatorcontrib>de Jongste, Johan C.</creatorcontrib><creatorcontrib>van der Wouden, Johannes C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric allergy and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bernsen, Roos M. D.</au><au>de Jongste, Johan C.</au><au>van der Wouden, Johannes C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Birth order and sibship size as independent risk factors for asthma, allergy, and eczema</atitle><jtitle>Pediatric allergy and immunology</jtitle><addtitle>Pediatr Allergy Immunol</addtitle><date>2003-12</date><risdate>2003</risdate><volume>14</volume><issue>6</issue><spage>464</spage><epage>469</epage><pages>464-469</pages><issn>0905-6157</issn><eissn>1399-3038</eissn><abstract>This study was carried out to disentangle the independent relations of birth order and sibship size with the presence of asthma, allergy and eczema. In a retrospective study, 700 families in the Netherlands were selected with index children born in 1988–90. Data were extracted from reports of health examinations at the age of 6 years of these children and their siblings. Birth order, and not sibship size, appeared to be a strong risk factor for allergy (excluding eczema). Children with higher birth order had a lower risk of allergy compared with first‐borns (adjusted odds ratios: 0.43, 0.26 and 0.05 for second‐, third‐ and fourth‐ or higher borns, respectively; p < 0.0001). Allergy including eczema also had a significant relation with birth order (p = 0.01). For asthma there appeared no clear relation with birth order. For asthma a non‐significant relationship with sibship size (adjusted for birth order) was found (p = 0.06): first‐born children in small sibships were more at risk than those in larger sibships. For allergy and eczema no such trend was observed. In conclusion, birth order is inversely related to the risk of allergy, independent of the size of the sibship.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>14675474</pmid><doi>10.1046/j.0905-6157.2003.00108.x</doi><tpages>6</tpages></addata></record> |
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| subjects | allergy asthma Asthma - epidemiology Biological and medical sciences Birth Order Child Child Welfare eczema Eczema - epidemiology Family Characteristics Family Health Female Fundamental and applied biological sciences. Psychology Fundamental immunology General aspects Humans Hypersensitivity, Immediate - epidemiology Male Medical sciences Multivariate Analysis Netherlands - epidemiology Prevalence Retrospective Studies Risk Factors Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Siblings sibship size Statistics as Topic |
| title | Birth order and sibship size as independent risk factors for asthma, allergy, and eczema |
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