Inhibition of Pneumococcal Carriage in Mice by Subcutaneous Immunization with Peptides from the Common Surface Protein Pneumococcal Surface Adhesin A
Pneumococcal surface adhesin A (PsaA), a common protein expressed on all 90 pneumococcal serotypes, is a vaccine candidate. Three anti-PsaAmonoclonal antibody phage display-expressed monopeptides (15 mers), in various formulations as lipidated or nonlipidated multiantigenic peptides or as bi- or tri...
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| Veröffentlicht in: | The Journal of infectious diseases 2002-02, Vol.185 (4), p.489-496 |
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| container_title | The Journal of infectious diseases |
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| creator | Johnson, Scott E. Dykes, Janet K. Jue, Danny L. Sampson, Jaquelyn S. Carlone, George M. Ades, Edwin W. |
| description | Pneumococcal surface adhesin A (PsaA), a common protein expressed on all 90 pneumococcal serotypes, is a vaccine candidate. Three anti-PsaAmonoclonal antibody phage display-expressed monopeptides (15 mers), in various formulations as lipidated or nonlipidated multiantigenic peptides or as bi- or tripeptide constructs, were studied in a mouse nasopharyngeal carriage model to determine the inhibitory effect of induced antibodies on carriage of pneumococcal serotypes 2, 4, and 6B. Antibodies to each of the various peptides tested reduced carriage of the 3 serotypes. Reduction in carriage by nonlipidated multiantigenic peptide antibodies was highly variable (39%–94%; mean, 59%; standard deviation [SD], 20.2%); however, more-consistent results were observed in mice immunized with lipidated (56%-98%;mean, 69%; SD, 13.6%) and combination or bipeptide (55%–91%; mean, 76%; SD, 13.1%) formulations. These peptides are immunogenic, and their induced antibodies reduce carriage in mice. PsaA peptides demonstrate potential for being important new vaccines against pneumococcal carriage, otitis media, and invasive pneumococcal disease. |
| doi_str_mv | 10.1086/338928 |
| format | Article |
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Three anti-PsaAmonoclonal antibody phage display-expressed monopeptides (15 mers), in various formulations as lipidated or nonlipidated multiantigenic peptides or as bi- or tripeptide constructs, were studied in a mouse nasopharyngeal carriage model to determine the inhibitory effect of induced antibodies on carriage of pneumococcal serotypes 2, 4, and 6B. Antibodies to each of the various peptides tested reduced carriage of the 3 serotypes. Reduction in carriage by nonlipidated multiantigenic peptide antibodies was highly variable (39%–94%; mean, 59%; standard deviation [SD], 20.2%); however, more-consistent results were observed in mice immunized with lipidated (56%-98%;mean, 69%; SD, 13.6%) and combination or bipeptide (55%–91%; mean, 76%; SD, 13.1%) formulations. These peptides are immunogenic, and their induced antibodies reduce carriage in mice. PsaA peptides demonstrate potential for being important new vaccines against pneumococcal carriage, otitis media, and invasive pneumococcal disease.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1573-6613</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/338928</identifier><identifier>PMID: 11865401</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adhesins, Bacterial ; Adjuvants, Immunologic - pharmacology ; Amino Acid Sequence ; Amino acids ; Animals ; Antibodies ; Antibodies, Bacterial - immunology ; Bacterial Proteins ; Bacteriology ; Biological and medical sciences ; Carrier Proteins - immunology ; Conjugate vaccines ; Female ; Fundamental and applied biological sciences. Psychology ; Immune response ; Immunization ; Injections, Subcutaneous ; Lipoproteins - immunology ; Major Articles ; Membrane Transport Proteins ; Mice ; Microbiology ; Molecular Sequence Data ; Monoclonal antibodies ; Nasopharynx - microbiology ; Peptide Fragments - immunology ; Pneumococcal Vaccines - immunology ; Preventive medicine ; Proteins ; PsaA protein ; Streptococcus pneumoniae ; Streptococcus pneumoniae - isolation & purification ; Vaccination ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><ispartof>The Journal of infectious diseases, 2002-02, Vol.185 (4), p.489-496</ispartof><rights>Copyright 2002 Infectious Diseases Society of America</rights><rights>2002 by the Infectious Diseases Society of America 2002</rights><rights>2002 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Feb 15, 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-d2ec0c7951e4a01917afd1f02e5a9a7a92f0e806971cfac66fe11231d6119d553</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30138073$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30138073$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13488835$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11865401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, Scott E.</creatorcontrib><creatorcontrib>Dykes, Janet K.</creatorcontrib><creatorcontrib>Jue, Danny L.</creatorcontrib><creatorcontrib>Sampson, Jaquelyn S.</creatorcontrib><creatorcontrib>Carlone, George M.</creatorcontrib><creatorcontrib>Ades, Edwin W.</creatorcontrib><title>Inhibition of Pneumococcal Carriage in Mice by Subcutaneous Immunization with Peptides from the Common Surface Protein Pneumococcal Surface Adhesin A</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>Pneumococcal surface adhesin A (PsaA), a common protein expressed on all 90 pneumococcal serotypes, is a vaccine candidate. Three anti-PsaAmonoclonal antibody phage display-expressed monopeptides (15 mers), in various formulations as lipidated or nonlipidated multiantigenic peptides or as bi- or tripeptide constructs, were studied in a mouse nasopharyngeal carriage model to determine the inhibitory effect of induced antibodies on carriage of pneumococcal serotypes 2, 4, and 6B. Antibodies to each of the various peptides tested reduced carriage of the 3 serotypes. Reduction in carriage by nonlipidated multiantigenic peptide antibodies was highly variable (39%–94%; mean, 59%; standard deviation [SD], 20.2%); however, more-consistent results were observed in mice immunized with lipidated (56%-98%;mean, 69%; SD, 13.6%) and combination or bipeptide (55%–91%; mean, 76%; SD, 13.1%) formulations. These peptides are immunogenic, and their induced antibodies reduce carriage in mice. PsaA peptides demonstrate potential for being important new vaccines against pneumococcal carriage, otitis media, and invasive pneumococcal disease.</description><subject>Adhesins, Bacterial</subject><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - immunology</subject><subject>Bacterial Proteins</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - immunology</subject><subject>Conjugate vaccines</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immune response</subject><subject>Immunization</subject><subject>Injections, Subcutaneous</subject><subject>Lipoproteins - immunology</subject><subject>Major Articles</subject><subject>Membrane Transport Proteins</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Monoclonal antibodies</subject><subject>Nasopharynx - microbiology</subject><subject>Peptide Fragments - immunology</subject><subject>Pneumococcal Vaccines - immunology</subject><subject>Preventive medicine</subject><subject>Proteins</subject><subject>PsaA protein</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - isolation & purification</subject><subject>Vaccination</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><issn>0022-1899</issn><issn>1573-6613</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2O0zAUhSMEYsoAbwDyIMEu4Bsn_llW5WcqFag0gFA3luvY1KWJix0LhvfgffGQMhVIiJUX5_M5OvcUxX3ATwFz-owQLip-o5hAw0hJKZCbxQTjqiqBC3FS3IlxizGuCWW3ixMATpsaw6T4Me83bu0G53vkLVr2JnVee63VDs1UCE59Msj16LXTBq0v0UVa6zSo3vgU0bzrUu--q1-_v7phg5ZmP7jWRGSD79CwMWjmuy6rFylYlS2WwQ8m-_0R9FucthsTszi9W9yyahfNvcN7Wrx_-eLd7LxcvH01n00Xpa45DGVbGY01Ew2YWmEQwJRtweLKNEoopkRlseGYCgY6B1BqDUBFoKUAom0aclo8GX33wX9JJg6yc1Gb3W4sKBnUjNQY_xcEXvG6bngGH_0Fbn0KfS4hqypvRFkjjm46-BiDsXIfXKfCpQQsr-aU45wZfHhwS-vOtEfssF8GHh8AFfMlbVC9dvHIkZpzTq6Kno2cT_t_hz0YmW0cfLimSI7hmJGsl6Pu4mC-XesqfJaUEdbI848r-fwDXi1m4o1ckZ9gnMpV</recordid><startdate>20020215</startdate><enddate>20020215</enddate><creator>Johnson, Scott E.</creator><creator>Dykes, Janet K.</creator><creator>Jue, Danny L.</creator><creator>Sampson, Jaquelyn S.</creator><creator>Carlone, George M.</creator><creator>Ades, Edwin W.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20020215</creationdate><title>Inhibition of Pneumococcal Carriage in Mice by Subcutaneous Immunization with Peptides from the Common Surface Protein Pneumococcal Surface Adhesin A</title><author>Johnson, Scott E. ; Dykes, Janet K. ; Jue, Danny L. ; Sampson, Jaquelyn S. ; Carlone, George M. ; Ades, Edwin W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-d2ec0c7951e4a01917afd1f02e5a9a7a92f0e806971cfac66fe11231d6119d553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adhesins, Bacterial</topic><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Bacterial - immunology</topic><topic>Bacterial Proteins</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - immunology</topic><topic>Conjugate vaccines</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immune response</topic><topic>Immunization</topic><topic>Injections, Subcutaneous</topic><topic>Lipoproteins - immunology</topic><topic>Major Articles</topic><topic>Membrane Transport Proteins</topic><topic>Mice</topic><topic>Microbiology</topic><topic>Molecular Sequence Data</topic><topic>Monoclonal antibodies</topic><topic>Nasopharynx - microbiology</topic><topic>Peptide Fragments - immunology</topic><topic>Pneumococcal Vaccines - immunology</topic><topic>Preventive medicine</topic><topic>Proteins</topic><topic>PsaA protein</topic><topic>Streptococcus pneumoniae</topic><topic>Streptococcus pneumoniae - isolation & purification</topic><topic>Vaccination</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnson, Scott E.</creatorcontrib><creatorcontrib>Dykes, Janet K.</creatorcontrib><creatorcontrib>Jue, Danny L.</creatorcontrib><creatorcontrib>Sampson, Jaquelyn S.</creatorcontrib><creatorcontrib>Carlone, George M.</creatorcontrib><creatorcontrib>Ades, Edwin W.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnson, Scott E.</au><au>Dykes, Janet K.</au><au>Jue, Danny L.</au><au>Sampson, Jaquelyn S.</au><au>Carlone, George M.</au><au>Ades, Edwin W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of Pneumococcal Carriage in Mice by Subcutaneous Immunization with Peptides from the Common Surface Protein Pneumococcal Surface Adhesin A</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2002-02-15</date><risdate>2002</risdate><volume>185</volume><issue>4</issue><spage>489</spage><epage>496</epage><pages>489-496</pages><issn>0022-1899</issn><eissn>1573-6613</eissn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Pneumococcal surface adhesin A (PsaA), a common protein expressed on all 90 pneumococcal serotypes, is a vaccine candidate. Three anti-PsaAmonoclonal antibody phage display-expressed monopeptides (15 mers), in various formulations as lipidated or nonlipidated multiantigenic peptides or as bi- or tripeptide constructs, were studied in a mouse nasopharyngeal carriage model to determine the inhibitory effect of induced antibodies on carriage of pneumococcal serotypes 2, 4, and 6B. Antibodies to each of the various peptides tested reduced carriage of the 3 serotypes. Reduction in carriage by nonlipidated multiantigenic peptide antibodies was highly variable (39%–94%; mean, 59%; standard deviation [SD], 20.2%); however, more-consistent results were observed in mice immunized with lipidated (56%-98%;mean, 69%; SD, 13.6%) and combination or bipeptide (55%–91%; mean, 76%; SD, 13.1%) formulations. These peptides are immunogenic, and their induced antibodies reduce carriage in mice. PsaA peptides demonstrate potential for being important new vaccines against pneumococcal carriage, otitis media, and invasive pneumococcal disease.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>11865401</pmid><doi>10.1086/338928</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 2002-02, Vol.185 (4), p.489-496 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adhesins, Bacterial Adjuvants, Immunologic - pharmacology Amino Acid Sequence Amino acids Animals Antibodies Antibodies, Bacterial - immunology Bacterial Proteins Bacteriology Biological and medical sciences Carrier Proteins - immunology Conjugate vaccines Female Fundamental and applied biological sciences. Psychology Immune response Immunization Injections, Subcutaneous Lipoproteins - immunology Major Articles Membrane Transport Proteins Mice Microbiology Molecular Sequence Data Monoclonal antibodies Nasopharynx - microbiology Peptide Fragments - immunology Pneumococcal Vaccines - immunology Preventive medicine Proteins PsaA protein Streptococcus pneumoniae Streptococcus pneumoniae - isolation & purification Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies |
| title | Inhibition of Pneumococcal Carriage in Mice by Subcutaneous Immunization with Peptides from the Common Surface Protein Pneumococcal Surface Adhesin A |
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